Episode #340. Think metabolic health is all about carbs and calories? You might be missing a crucial part of the puzzle. Join me as I break down how the location and type of fat your body stores can dramatically impact your health and risk of disease. In this episode, you'll learn how body fat distribution influences your risk of metabolic disease, why weight impacts individuals differently, and how to determine if you have excess fat in your liver. Plus, discover my 6 key tips for enhancing your metabolic health through diet, exercise, and lifestyle adjustments. Specifically, we discuss: 00:00 What Is Metabolic Health and Why It Matters 00:41 The Root Cause of Poor Metabolic Health Revealed 02:55 Understanding Your Personal Fat Threshold (Key to Fat Loss) 04:32 The Twin Cycle Hypothesis: How Fat Affects Metabolism 05:10 Liver Fat: The Hidden Culprit of Metabolic Disorders 16:16 6 Proven Strategies to Reduce Ectopic & Visceral Fat 33:36 Key Takeaways: Fixing Metabolic Health in 6 Steps 35:00 Bonus Discover more insights and supporting studies in the full show notes. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Follow this link to Eimele's website for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code LIVINGPROOF at checkout for 25% off and receive a free gift of 5 nights of their best-selling Sleep packs for orders over $75 at livemomentous.com. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF to get up to $600 off your Pod 4 Ultra purchase when bundled at eightsleep.com/theproof. This is their highest offer of the year! Try it risk-free for 30 days, with worldwide shipping. Birch Sleep deeply and wake up refreshed with a Birch Natural Mattress, combining premium natural materials with unbeatable comfort. Rest easy with a 100-night trial and 25-year warranty. Get 25% off all mattresses and 2 free pillows at birchliving.com/simonhill. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #339. Are you getting the full picture of your heart health? Learn why ApoB is the test you shouldn't skip. In this episode, I sit down with Dr Daniel Soffer, a preventive cardiologist and lipidologist, to break down the importance of ApoB testing for cardiovascular risk assessment. You'll learn why ApoB provides more comprehensive insights than LDL cholesterol alone, who can benefit most from this test, and how it fits into preventive cardiology. Dr Soffer shares practical advice for assessing cardiovascular disease risk, discusses the implications of diet and genetics on heart health, and explores case studies to help you understand when and why ApoB testing is crucial. Specifically, we discuss:  Introduction (00:00) Insight into Preventive Cardiology and Lipidology (01:38) Understanding Lipoproteins and Their Role in Cardiovascular Disease (06:40) Techniques for Lipoprotein Testing and Measurement (11:33) Exploring Atherosclerosis and Lipoprotein Retention Hypothesis (31:18) Epidemiological Changes in Health and Cardiovascular Profiles (55:06) Concerns about the Keto Diet and Elevated ApoB Levels (58:26) Approaches to Managing Elevated LDL Levels Clinically (01:01:13) The Role of Evidence-Based Medicine in Cardiovascular Guidelines (01:07:15) Comparing ApoB and LDL Cholesterol in Cardiovascular Risk (01:14:36) Understanding Discordance in Lipid Measurements (01:18:36) Advanced Imaging Techniques for Risk Assessment (01:25:50) Guidelines and Considerations for Statin Therapy (01:44:30) Coronary Artery Calcium Score, Stroke Risks, and Carotid Ultrasound (01:54:03) Dietary Interventions and Carotid Intima-Media Thickness (IMT) (01:59:22) Case Study: Family History’s Role in Cardiovascular Risk (02:05:05) Overview of Statins, PCSK9 Inhibitors, and Other Lipid-Lowering Therapies (02:12:24) Aspirin Therapy and Imaging in Cardiovascular Health (02:26:06) Setting Treatment Thresholds Based on ApoB Levels (02:39:57) Closing Thoughts on Cardiovascular Risk and ApoB (02:44:16) This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Use code LIVINGPROOF at checkout for 25% off and receive a free gift of 5 nights of their best-selling Sleep packs for orders over $75 at at livemomentous.com. Pique Tea Pique’s Black Friday special is HERE. For a limited time, get a Chai tea FREE with your qualifying purchase at piquelife.com/simon. This is the only time you can get your hands on their Chai. Act fast; this limited-time offering is sure to sell out! The offer ends November 16th. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF to get up to $600 off your Pod 4 Ultra purchase when bundled at eightsleep.com/theproof. This is their highest offer of the year! Try it risk-free for 30 days, with worldwide shipping. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook

Episode #338. Struggling with acne, aging, or other skin concerns? Discover how to build a science-backed skincare routine with insights from Carter “Eviba” Gottlieb. In this episode, I’m joined by Carter and special guest Tawny Janae to explore the essentials of skincare, breaking down what truly works and what might be a waste of time and money. You’ll learn about foundational skincare steps, the benefits of active ingredients like retinoids and niacinamide, and how to protect your skin from sun damage. Carter also shares tips for managing acne, avoiding common skincare myths, and building a routine that supports long-term skin health. If you’re looking to enhance your skin’s appearance and health, this episode is packed with practical, evidence-based advice. Specifically, we discuss: Introduction: Unveiling the Science of Skin Care (00:00) Carter’s Path into Dermatology and Science-Based Skincare (04:35) Carotenoids and Their Effects on Skin Health and Appearance (08:58) Debunking Myths About Supplements and Skincare (17:31) Essentials of Skin Care: Slugging, Moisturizers, and More (29:03) Retinoids Explained: Anti-Aging Powerhouses (37:31) How Exercise and Hydration Affect Skin Health (52:41) Tips for Choosing the Right Moisturizer (53:40) Understanding Skin Pigmentation and Anti-Ageing (56:38) Why Sunscreen Is the Ultimate Skin Protector (01:07:32) How to Choose the Best Sunscreen for Your Skin (01:17:58) Do Skincare Devices Really Work? (01:37:30) Gua Sha and the Benefits of Facial Massages (01:45:04) The Truth About Facials and Chemical Treatments (01:47:23) Effective Acne Treatments: Science-Backed Solutions (01:56:02) Pimple Popping: What You Should and Shouldn't Do (02:05:36) Final Thoughts on Skincare (02:14:05) Connect with Carter Gottlieb on TikTok, Instagram, YouTube, or at evibacarter.com. Connect with Tawny Janae on Instagram or YouTube, and discover 300+ classes on Alo Moves. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT – a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Birch Sleep deeply and wake up refreshed with a Birch Natural Mattress, combining premium natural materials with unbeatable comfort. Rest easy with a 100-night trial and 25-year warranty. Get 20% off all mattresses and 2 free pillows at birchliving.com/simonhill. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 20% off your first purchase by using the code LIVINGPROOF at checkout at livemomentous.com Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify

Episode #337. An estimated 45% of dementia cases are preventable – find out how you can reduce your risk by targeting these 14 modifiable factors. Today I’m joined by Dr Kellyann Niotis, the first fellowship-trained preventive neurologist, to explore the latest research on dementia prevention and how simple lifestyle changes can dramatically reduce your risk. In this episode, we break down The Lancet’s 14 modifiable risk factors for dementia, from managing LDL cholesterol and staying physically active to addressing hearing loss and improving your mental health. You’ll also learn about the links between nutrition, sleep, and brain health, and why it’s never too early – or too late – to start taking care of your brain. Specifically, we discuss: Introduction (00:00) Pioneering Preventive Neurology (00:07) Decoding Neurodegenerative Diseases (00:56) Understanding the Phases of Neurodegeneration (02:09) Early Indicators: Preclinical Signs and Cognitive Impairment (07:12) Uncovering Dementia’s Risk Factors and Preventive Steps (11:33) How Education Builds Cognitive Reserve Against Dementia (22:37) Why Vision and Hearing Loss Could Raise Dementia Risk (27:45) The Link Between Oral Health and Cognitive Decline (40:45) How Depression Influences Dementia Risk (52:33) Head Trauma’s Impact on Cognitive Health (59:21) How Head Injuries May Contribute to Dementia (01:01:35) How Exercise Benefits Brain Health and Longevity (01:11:43) Social Connections: A Key to Cognitive Health (01:23:56) How Diabetes Increases Dementia Risk (01:30:03) Hypertension’s Role in Cognitive Decline (01:48:00) Optimal Blood Pressure Goals for Brain Health (01:59:08) Alcohol’s Effects on Brain Function (02:01:12) Recreational Drugs and Brain Degeneration (02:09:38) Smoking’s Effect on Dementia Risk (02:12:00) The Link Between Air Pollution and Cognitive Health (02:17:49) Environmental Toxins and Dementia Risk (02:22:35) Diet Choices That May Help Prevent Dementia (02:29:30) Why Quality Sleep is Essential for Brain Health (02:35:44) Menopause’s Influence on Dementia Risk (02:46:26) Closing Thoughts and Contact Information (02:52:28) Connect with Dr Kellyann Niotis on Instagram, LinkedIn, and via her website, https://drkellyannniotis.com/. Listen to her appearance in Episode #333 here. Head to the full show notes for additional insights and supporting studies. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 20% off your first purchase by using the code LIVINGPROOF at checkout at livemomentous.com Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Pique Tea Stay energised without the coffee crash with Pique’s Sun Goddess Matcha. Organic, ceremonial-grade, and uniquely loaded with l-theanine to keep you calm and focused. Get up to 15% off plus a free beaker and frother at piquelife.com/simon. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping.

Episode #336. What if our food systems could help heal the Earth? Join me as I sit down with ethnobotanist Stephen Brooks to explore permaculture, alternative living, and the future of agriculture. Together, we discuss how you can be part of the solution to building a better balance between humans and nature. You’ll learn about the principles of permaculture, the ethical issues in modern food systems, and some unique fruits to seek out. Stephen also shares his vision for designing cities and agriculture that work in harmony with the planet, and why now is the time to get involved in the transition to a healthier world. Specifically, we discuss: The World of Fruit and Plants: Connection to Nature (00:00) From Miami to Costa Rica: A Journey into Sustainability (03:59) Environmental Injustice and the Impact on Communities (05:08) Permaculture and Sustainable Agriculture Practices (11:54) How to Build Sustainable Communities through Permaculture (26:30) Perennial Vegetables: A Key to Sustainable Agriculture (39:15) Diet Trends, Agriculture, and Sustainable Living Practices (41:56) Sustainable Human Systems: Permaculture and Design (48:59) Renewable Energy Solutions for Sustainable Communities (01:16:32) Practical Urban Farming and Sustainable Practices (01:19:55) The Joy of Nitrogen-Fixing Plants and Sustainable Farming (01:30:36) Fruit Ceremonies: Building Community and Connection (01:38:30) Blueprint for Sustainable Living and Community Building (01:44:30) Connect with Stephen on Instagram, where you can find more information about his current and upcoming projects. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Birch Sleep deeply and wake up refreshed with a Birch Natural Mattress, combining premium natural materials with unbeatable comfort. Rest easy with a 100-night trial and 25-year warranty. Get 20% off all mattresses and 2 free pillows at birchliving.com/simonhill. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #335. Struggling to keep weight off long term? Learn the science behind successful fat loss and maintenance with experts Kevin Maki, PhD, and Carol Kirkpatrick, PhD. In this episode, we discuss evidence-based strategies for losing body fat and keeping it off, while exploring the role of nutrition, exercise, and pharmacological interventions. You’ll learn about the impact of protein and fibre on hunger and satiety, the benefits of regular exercise for insulin sensitivity, and the potential role of medications like GLP-1 agonists. Dr Maki and Dr Kirkpatrick also share insights on the challenges of maintaining weight loss and how to make lasting changes for better health. Specifically, we discuss: Introductions (00:00) Carol’s Journey into Nutrition and Research Development (04:27) Kevin’s Path in Cardiometabolic Health Research (11:53) The Importance of Observational Studies in Nutrition (14:59) Understanding Dietary Fats and Cardiometabolic Health (19:49) Public Health Nutrition: Current Challenges and Opportunities (31:55) Exploring Obesity and Its Impact on Metabolic Health (43:19) How Exercise Enhances Insulin Sensitivity (53:35) The Link Between Insulin Resistance and Ectopic Fat (55:01) Weight Loss Challenges: Why It’s So Hard to Keep the Weight Off (01:01:05) How GLP-1 Agonists Are Transforming Obesity Treatment (01:04:02) Behavioural Aspects of Obesity: Understanding the Psychology (01:11:22) The 30-30-30 Study: A New Approach to Sustainable Weight Loss (01:24:44) Cholesterol, Fibre, and Cardiovascular Health (01:44:02) Protein Supplements and How They Affect Digestion (01:46:56) Dietary Patterns and Regulating Appetite for Better Health (01:49:23) Exploring the 30-30-30 Framework for Weight Loss (01:51:49) How Protein Sources Influence Metabolic Health (01:57:53) Carbohydrate Quality vs. Restriction: What Matters More? (02:14:57) Exercise for Weight Maintenance and Long-term Health (02:27:12) The Future of Nutrition Research and Public Health (02:30:25) Final Thoughts (02:35:10) Connect with Kevin Maki, PhD on LinkedIn and at https://www.mbclinicalresearch.com/. Connect with Carol Kirkpatrick, PhD on Twitter/X and LinkedIn. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 20% off your first purchase by using the code LIVINGPROOF at checkout at livemomentous.com Pique Tea Stay energised without the coffee crash with Pique’s Sun Goddess Matcha. Organic, ceremonial-grade, and uniquely loaded with l-theanine to keep you calm and focused. Get up to 15% off plus a free beaker and frother at piquelife.com/simon. Eight Sleep Upgrade your sleep with the Pod 4 Ultra by Eight Sleep. Clinically validated to deliver up to 1 extra hour of quality sleep per night through temperature control and biometric tracking. Use code THEPROOF for $350 off at eightsleep.com/theproof. Try it risk-free for 30 days, with worldwide shipping. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #334. Can we turn back the clock on our biology? Join me as I sit down with Nobel Prize-winning structural biologist Dr Venki Ramakrishnan to discuss why we age, how we age, and the scientific advancements helping us live longer and healthier lives. In this episode, you'll learn about the core reasons behind aging, the role of ribosomes and DNA damage in this process, and the science behind popular longevity interventions. Dr Ramakrishnan shares his insights on misleading anti-aging claims, how much control we truly have over aging, and the truth about "biological age". We also explore practical ways to slow down aging and extend our healthspan. Specifically, we discuss: Introduction to Aging and Longevity Science (00:00) Ribosomes and Their Role in Longevity Research (00:57) Controversies in Anti-Aging Research (05:09) Understanding the Biology of Aging (11:25) Genetics and Evolution: How They Shape Human Lifespan (22:10) Youthful Cells: The Future of Longevity Studies (29:38) Biological Interventions in Aging: Potential and Risks (46:09) Ancestral Living and Traditional Medicine for Longevity (52:09) Cellular Aging Mechanisms: A Deeper Look (56:51) Protein Synthesis and Its Impact on Aging Processes (01:04:19) DNA Damage and Repair: Implications for Aging (01:16:53) Lifestyle Choices That Influence Aging and Lifespan (01:24:03) Philosophical Perspectives on Extended Human Longevity (01:32:53) Concluding Thoughts on Aging and Longevity Research (01:43:21) Learn more about Dr Venki Ramakrishnan here, and be sure to check out his books Gene Machine and Why We Die. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 20% off your first order and subscriptions. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #333. What does cholesterol have to do with dementia? Learn how to protect your brain health in the long term with this information you should be considering from your twenties and thirties. From cutting-edge science on cholesterol metabolism to fourteen key risk factors for dementia, we break down what you can do now to reduce your risk of cognitive decline later. In this episode, I’m joined by two renowned experts, Dr Kellyann Niotis and Dr Thomas Dayspring. Together, we explore the connection between cholesterol and dementia, personalised prevention strategies, and how making lifestyle changes today can safeguard your brain for the future. Specifically, we discuss: Intro (00:00) Cardiology Meets Neurology: Understanding the Connection (07:53) Dementia and Neurodegenerative Diseases: A Comprehensive Overview (13:26) Recognizing Early Dementia Signs and Risk Factors (21:43) Lipoproteins and Brain Health: The Crucial Link (32:36) ApoB vs ApoE: Comparing Apoprotein Functions in Neurological Health (44:24) APOE4 Carriers: Potential Therapeutic Approaches (01:00:30) ApoA1 and HDL: Their Role in Dementia Prevention (01:03:27) Genetic Testing for Dementia: Understanding APOE4 Implications (01:13:19) APOE4 Gene: Impact on Dementia Risk and Brain Health (01:17:58) Desmosterol's Role in Maintaining Brain Health (01:20:56) LDL Cholesterol: A Key Factor in Dementia Risk Assessment (01:34:05) APOE4: Comparing Single vs. Double Copy Risk Factors (01:39:15) Omega-3 Fatty Acids: Essential Nutrients for Brain Health (01:38:49) LDL Cholesterol Levels: Assessing Low vs. High Risk for Dementia (01:56:50) Key Takeaways: Preventive Neurology and Future Research Directions (02:00:10) Connect with Dr Kellyann Niotis at https://drkellyannniotis.com/ and discover research and resources at https://ind.org/. Connect with Dr Thomas Dayspring on Twitter/X or LinkedIn, and listen to his past appearances on The Proof here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Birch Sleep deeply and wake up refreshed with a Birch Natural Mattress, combining premium natural materials with unbeatable comfort. Rest easy with a 100-night trial and 25-year warranty. Get 25% off all mattresses and 2 free pillows at birchliving.com/simonhill. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #332. Blood tests can be confusing, but they don’t have to be. Learn how to interpret your comprehensive blood test results as I walk through key markers for cardiometabolic, hormonal, and overall health. Discover why I recommend blood tests every 6–12 months, learn the results of my most recent blood test, and hear insights from esteemed scientists Dr Thomas Dayspring and Dr Karl Nadolsky in this thorough guide. Specifically, I cover: Introduction (00:00) Personal Health Journey and Lifestyle Context (04:06) Cardiometabolic Biomarkers: Cholesterol, Triglycerides, and ApoB (09:29) Debunking the Triglycerides-to-HDL Ratio Debate (20:56) Insulin Sensitivity and Metabolic Health Markers (29:10) Hormones: Testosterone Levels and Testing (30:42) Thyroid Function: Family History and Test Interpretation (37:19) Iron and Micronutrient Insights (50:12) Key Lifestyle Habits for Optimal Health and Final Thoughts (51:44) Download my full blood test results here, or head to the full show notes for additional resources and supporting studies. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com. Pique Tea Stay energised without the coffee crash with Pique’s Sun Goddess Matcha. Organic, ceremonial-grade, and uniquely loaded with l-theanine to keep you calm and focused. Get up to 15% off plus a free beaker and frother at piquelife.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #331. Are you getting the right balance of omega-3 and omega-6 fats in your diet? Join me as I sit down with leading scientists to explore the role these essential fatty acids play in your health. From brain development and cognitive function to heart health and inflammation, we unpack how these fats impact your well-being and address common misconceptions about omega-6 fats. You’ll hear from top voices in nutrition, including Dr Bill Harris, Dr Joel Fuhrman, Dr Ayesha Sherzai, Dr Dean Sherzai, Dr Gary Fraser, Dr Phillip Calder, and Dr Kristina Harris. Each expert shares valuable insights into how omega-3s and omega-6s influence everything from cognitive function to heart disease. We cover: Introduction to Omega-3 and Omega-6 Fatty Acids (00:00) What is Omega-6 and Why the Body Needs It (01:06) What is Omega-3 and Do We Really Need It? (12:29) The Importance of Optimising Omega-3 Consumption (42:50) Understanding DHA and EPA: Why Are They Essential? (50:01) Are Omega-3s the Most Important Fatty Acids for Brain Health? (55:44) APOE4 and Omega-3 Supplementation: What You Need to Know (1:08:50) Low Omega-3 Index and Neurological Problems in Seventh-day Adventist Church Members (1:15:00) Omega-3 Supplementation vs Fatty Fish: What Does Research Indicate? (1:21:53) Understanding Essential Fats: Benefits and Sources (1:27:25) Low Conversion Rates: From ALA to EPA & DHA Explained (1:31:39) The Importance of Monitoring Omega-6 Intake (1:37:03) The Link Between Omega-6 Fatty Acids and Inflammation (1:40:55) Major Omega-6 Food Sources and Healthier Alternatives (1:45:45) Balancing Omega-3 & Omega-6 to Reduce Inflammation (1:50:25) The Health Implications of Replacing Saturated Fat with Linoleic Acid (1:53:48) Polyunsaturated Fats and Cardiometabolic Health (1:58:19) How Omega-3 & Omega-6 Influence Insulin Resistance and Blood Pressure (2:01:44) The Long-Term Impact of Consuming Polyunsaturated Fats (2:06:32) Why You Should Measure Your Omega-3 Levels (2:10:07) DHA and EPA: Food Sources and Effective Supplementation (2:14:20) What Forms of DHA and EPA Supplementation Are Most Effective? (2:18:37) How to Properly Store DHA and EPA Supplements (2:20:27) Pregnancy and Omega-3s: Essential Benefits (2:21:33) Supplementing Omega-3s During Pregnancy: Guidelines (2:29:55) Omega-3 Supplementation Protocol: A Comprehensive Guide (2:38:16) Outro (2:52:15) Thank you for tuning in, and for your ongoing commitment to your health. If you found this episode helpful, please share it with someone who could benefit from it. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #330. Uncover the key foundations of a healthy diet and learn how to reduce your risk of chronic disease. What does it take to truly eat well? How do you stay healthy in a food system that prioritises profit? In this episode, originally recorded for Sigma Nutrition Radio, I answer these questions and more. Learn practical, science-based strategies for building healthier eating habits that can have a lasting impact on your well-being. Tune in to explore topics like nutrition, chronic disease prevention, and how to make informed dietary choices for better long-term health. Specifically, we discuss: Introduction (00:00) Simon’s Background and Journey into Nutrition Science (01:26) The Importance of Science and Objectivity in Nutrition Advice (08:38) Barriers to Healthy Eating and Population-Level Solutions (16:06) Challenges of Adopting Plant-Based Diets and Solutions (30:38) Omega-3 Fatty Acids: Health Benefits and Plant-Based Sources (38:17) Conclusion and Final Thoughts on Nutrition and Health (47:21) This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease. In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD. Specifically, we discuss: Intro (00:00) What is Metabolic Health (01:35) Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02) The Importance of Skeletal Muscle for Metabolic Health (20:03) Exercise for metabolic health ****Zone 2 (28:36) Twin Cycle Hypothesis (56:45) Understanding the Personal Fat Threshold (01:08:15) Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08) Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46) Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39) The Science of Hepatic Fat Oxidation (01:49:37) Consequences and Effects of Fatty Liver Disease (01:55:14) Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42) Combination of Fructose and Saturated fat on Metabolic Health (02:13:21) Type of fat and its effect on Metabolic Health (02:17:35) What cause Metabolic Health: fat or fructose (02:24:01) New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50) Modern Techniques for Accurate Body Fat Measurement (02:31:52) Health metabolic biomarkers (02:36:51) Ectopic fat (02:38:19) Fat storage and metabolic health (02:39:10) Evolutionary Insights into Human Fat Storage (02:42:02) Fatty Liver Disease (02:45:46) Outro (2:57:46) Connect with today’s guests and listen to their previous episodes at the links above. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Episode #328. Are eggs a superfood or a ticking time bomb? The answer is in your genes. Join me to unpack the surprising science of how eggs affect your health depending on your genetic makeup, helping you understand if they’re safe for you. Discover the two tests you can take to find out if you’re among the 30% of people who are cholesterol hyper-absorbers. You’ll also learn the difference between dietary and blood cholesterol, why cholesterol absorption varies, and what steps to take based on your test results. Specifically, we discuss: Introduction: Are Eggs Superfoods or Cholesterol Bombs? (00:00) Understanding Cholesterol: Dietary vs. Blood Levels (01:25) The Genetic Factors Influencing Cholesterol Absorption (04:31) Identifying Cholesterol Hyperabsorbers: Are You One? (09:20) Testing Methods for Cholesterol Sensitivity (12:41) Dietary Tips for Cholesterol Hyperabsorbers (13:59) Key Insights: 5 Critical Facts About Eggs and Heart Health (18:06) Concluding Thoughts (21:23) Head to the full show notes for supporting studies and phytosterol testing options. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #327. Butter, bone broth, and eating like our ancestors: join me on The Ellen Fisher Podcast to bust some prolific nutrition myths. Tune in to unpack my core nutrition philosophy, evaluate how popular diets can impact your health, and examine some key foods that are either idolised as superfoods or condemned as dangerous. If you have questions about keto, carnivore, antinutrients, or other hot nutrition topics, this episode is for you. Specifically, we discuss: Introduction (00:00) Exploring Personal Nutritional Philosophy (02:31) Science's Role in Nutritional Understanding (06:33) Integrating Science and Nature in Dietary Patterns (10:55) Ancestral Diets Explained (14:40) Saturated Fats and ApoB: Their Crucial Role in Diet (21:03) Strategies for Reducing Saturated Fat and ApoB Levels (26:49) Analyzing Evidence Against Saturated Fat Claims (30:16) Polyunsaturated Fats: Health Impacts Unveiled (40:13) Processed Foods and Overconsumption Risks (47:33) Butter and Saturated Fats: Revealing the True Health Effects (49:26) Comparative Analysis of Various Diets and Health Outcomes (53:30) Debunking Anti-Nutrient Myths (01:04:36) Debating Contrasting Nutritional Perspectives with Paul Saladino (01:16:07) Saturated Fats Comparison: Coconut vs. Red Meat (01:22:26) The Importance of Personal Health Metrics (01:25:15) Evaluating Plant Milks and Processed Food Alternatives (01:29:26) Beef Liver Consumption and Nutrient Toxicity Risks (01:31:15) Critiquing Vegan Diets and Low-Fat Diet Misconceptions (01:36:54) Holistic Health and Longevity: Defining the Ultimate Goal (01:45:32) Conclusion and Key Takeaways (01:48:07) Discover more of the Ellen Fisher podcast at https://www.ellenfisher.com/podcast, or listen to her previous appearance on The Proof. Visit the full show notes for more insights and supporting studies. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #326. Could the oils you’re using in the kitchen be increasing your risk of chronic disease? Explore the essential facts about dietary fats and how they affect your health markers in this focused deep dive. Learn which oils to eat and avoid, how to adjust your diet for optimal intake, and how fats can make the difference between health and chronic disease. Specifically, I cover: Introduction to Dietary Fats (00:00) Types of Fats Explained (02:27) Essential vs. Non-Essential Fats - What's the Difference? (07:54) Fats and Cardiovascular Health - Unveiling the Connection (10:32) How Dietary Fats Influence Blood Pressure (17:47) The Fat-Inflammation Link (20:29) Exploring the Relationship Between Fats and Insulin Resistance (26:03) Long-Term Health Outcomes of Dietary Fat Consumption (29:51) Optimising Fat Intake: Practical Dietary Recommendations (36:22) Wrapping up and Final Thoughts (41:25) Head to the full show notes for additional resources and supporting studies. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #325. Fish oil supplements: harmful or heart-healthy? Learn about the risks and benefits of omega-3 supplementation, including an analysis of a new study that’s been making waves. Discover how to test your omega-3 levels, how to achieve the optimal index, and my supplement recommendations for a healthy heart and planet. Specifically, I cover: Introduction to Omega-3 Fatty Acids and Fish Oil Supplements (00:00) New Research Reveals Fish Oil's Impact on Cardiovascular Health (01:03) Challenging Assumptions - A Different Take on the Fish Oil Study Results (05:14) Dr. Bill Harris Weighs In - Expert Opinions on Omega-3 Benefits (09:03) How Can I Increase My Omega-3 Levels? Practical Advice for Everyday Life (17:26) Omega-3 Supplement Strategy (18:50) Comparing Sustainable Omega-3 Sources: Algae Oil vs. Fish Oil (24:05) How much omega-3 is too much (25:58) Does the form of DHA and EPA matter? (28:00) Does EPA DHA ratio matter? (28:44) Omega-3 Supplementation for Vegans and Vegetarians (31:50) Key Takeaways and Recommendations for Omega-3 Supplementation (35:55) Head to the full show notes for additional insights and supporting resources. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #324. A crash course for carnivores: let’s talk saturated fat, heart disease, and protein as I’m interviewed on Mark Bell’s Power Project. Do you need to change your diet if you’re feeling good? Can you be overweight and healthy? What simple changes can meat eaters make to improve their long-term health? Hear my answers to these questions and more in this episode. We cover: Introduction and Podcast Overview (0:00) Finding Common Ground in Nutritional Science (02:15) Genetic Testing and Personalised Nutrition (06:48) Heart Health Unveiled: The Saturated Fat and ApoB Connection (10:40) Nutritional Strategies vs Medication for Lowering ApoB (18:39) Understanding Epidemiology Studies on Red Meat (27:07) Practical Tips for Transitioning from Animal to Plant Protein (42:05) A Personal Journey with Nutrition (48:53) Weight Loss and Metabolic Health Insights (53:41) Exploring Health Impacts of an All-Meat Diet (01:02:59) Comparing Plant and Animal Protein Bioavailability (01:12:13) The Role of Protein in Satiety (01:16:44) Addressing Seed Oils (01:20:16) Incorporating Vegetables and Plant Proteins for Optimal Health(01:27:30) Carnivore Diet vs Plant-Based Diet Discussion (01:33:34) The Undeniable Importance of Resistance Training (01:39:13) Ensuring Adequate Intake for Thyroid Health (01:47:23) Final Thoughts and Farewell (01:50:12) In this episode, we discuss the importance of getting regular blood tests. Download my free blood test guide to get started. Connect with Mark Bell, Nsima Inyang, and Andrew Zaragoza on Instagram. If you’re interested in hearing more of Mark Bell’s Power Project, head to https://powerproject.live/. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #323. Oreo cookies or statins – which is more effective in reducing LDL cholesterol? The results from one study might surprise you. Join me as I sit down with Oxford PhD graduate and Harvard Medical student Dr Nick Norwitz to discuss the lipid energy model, what it has to do with Oreos, and how different diets affect your health. You’ll learn about Dr Norwtiz’s health journey, including his experience with inflammatory bowel disease and the ketogenic diet. We discuss cholesterol management and cardiovascular disease risk, lean mass hyper-responders, and statins. This episode is an important and informative reflection on scientific curiosity and misinformation. Specifically, we discuss: Introduction (00:00:00) The Importance of Curiosity in Scientific Progress (04:39) Exploring the Oreo vs. Statin Experiment on Lean Mass Hyper Responders (08:52) Scientific and Clinical Impact of the Oreo Study (25:03) Addressing Criticisms and Misinterpretations of the Study (34:47) Navigating Statin Discussions on Social Media (40:27) Debunking Claims About PCSK9 Inhibitors (53:18) Challenging Misinformation in Health Communities (59:15) The Lipid Energy Model and Lean Mass Hyper Responders Explained (01:06:59) Defining Lean Mass Hyper Responders: Key Terminology (01:14:19) Practical Advice for Lean Mass Hyper Responders (01:30:35) The Carnivore Kid: An Intriguing Case Study (01:41:48) Personal Struggles with Ulcerative Colitis and Starting Keto (01:45:24) Balancing Medication and Personal Health Choices (01:50:31) Debating Dietary Interventions for Inflammatory Bowel Disease (02:11:09) Challenges in Dietary Research and Medical Interventions (02:25:55) Introducing the Lipid Energy Model and Its Mechanisms (02:34:49) Debating the Validity of the Lipid Energy Model (02:44:29) Long-Term Effects of Ketosis and Carb Restriction (02:52:31) Critiques and Limitations of the Lipid Energy Model (02:57:17) ApoB-Containing Lipoproteins and Atherosclerosis (03:03:50) Current Research and Future Directions on LMHR (03:06:41) Exploring Inflammatory Responses to Fibre (03:16:12) The Link Between Saturated Fats and Heart Disease (03:20:49) Closing Thoughts on Effective Scientific Communication (03:25:29) The Lean Mass Hyper Responders Debate: Addressing Frustrations (03:32:32) Understanding Carbohydrate Reintroduction Physiology (03:46:58) Diet-Specific Strategies to Lower ApoB (03:55:16) Examining Claims About ApoB and Cardiovascular Disease (04:01:50) Trade-offs in Lowering ApoB Levels (04:12:54) Exploring the Link Between All-Cause Mortality and ApoB (04:22:42) Lean Mass Hyper Responders and ApoB: A Unique Profile (04:44:54) Concluding Thoughts and Future Discussion Topics (04:48:10) Connect with Nick Norwitz, PhD on Twitter/X, Instagram, and YouTube. Make sure to check out the full show notes for additional resources and supporting studies. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill

Episode #322. Did you know that 30% of cancers are related to obesity? Join me as I sit down with Harvard Professor and endocrinologist Dr Christos Mantzoroz to discuss fatty liver disease, metabolic health, and hormones. You’ll learn about why so many people are obese and whether you can be overweight and healthy. Dr Mantzoroz breaks down budget-friendly ways to evaluate your metabolic health, explains how hormones affect your weight, and offers his insight on how to treat obesity. Overall, this episode is a masterclass in metabolic health and fatty liver disease. Specifically, we discuss: Introduction to The Latest Obesity Research Findings (00:00) The Evolving Understanding of Obesity Science (03:49) Uncovering New Fat Storage Mechanisms (10:57) Modern Techniques for Accurate Body Fat Measurement (15:02) Why Maintaining Weight Loss Is So Challenging (20:01) Evolutionary Insights into Human Fat Storage (25:12) How Leptin Regulates Energy Balance and Health (29:17) New Approaches to Break Through Weight Set Points (39:27) Environment's Role in Weight Gain Beyond Diet (45:49) Decoding the Genetics of Fat Storage and Metabolism (52:59) Non-Alcoholic Fatty Liver Disease Explained (55:40) Evidence-Based Nutrition for Optimal Liver Health (01:05:25) Promising Advances in Non-Invasive Liver Tests (01:10:49) Oestrogen's Impact on Metabolism (01:20:14) The Link Between Liver Fat and Insulin Resistance (01:22:04) Addressing America's Growing Metabolic Health Crisis (01:26:11) Outro (01:27:11) Connect with Christos Mantzoros, MD DSc PhD h.c. mult. on LinkedIn, and discover his work here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #321. You’ve heard me interview hundreds of nutrition experts; now it’s time for me to share my comprehensive views on nutrition, health, and longevity. Join me as I’m interviewed by André Duqum in this conversation originally recorded for the Know Thyself podcast. This episode covers the foundations of healthy eating and my take on common nutrition controversies. You’ll learn how to decode health information you find online, why a plant-focused diet is the best way forward, and how to discover the optimal diet for you. Overall, we discuss what to eat and avoid, when to eat, and how your food choices impact your body and the planet. Specifically, we discuss: Understanding Nutrition Science (04:07) The Role of Observational Studies in Nutrition (09:18) What Is the Most Beneficial Diet for Humans? (13:12) Simon Hill's Personal Journey and Motivation (19:38) Five Pillars of Longevity (27:50) Importance of Protein in the Diet (31:27) Understanding Seed Oils and Polyunsaturated Fats (50:23) Importance of Fibre in the Diet (58:32) Choosing the Best Animal Proteins (01:10:06) Role of Fake Meats in a Plant-Based Diet (01:14:52) Metabolic Health and Dietary Fats (01:19:40) Supplementation and Nutrient Gaps (01:24:22) Debunking Myths About Anti-Nutrients in Plants (01:30:20) The Soy Controversy Explained (01:38:20) Challenges of Plant-Based Diets (01:41:29) Environmental Impact of Diet Choices (01:59:04) Optimising Meal Timing (02:07:07) Importance of Relationships for Longevity (02:12:52) Connect with André Duqum on Instagram, and discover the Know Thyself podcast on Instagram or at the official website, https://www.knowthyself.one/. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. LMNT Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #320. Are you part of the 20% of people with this dangerous gene? There’s a cheap, simple test you can do just once in your life to find out. Join me as I sit down with renowned lipidologist Dr Thomas Dayspring to help you understand Lipoprotein(a) and the test that might change your life. In this episode, you’ll learn what Lp(a) is and how it can affect your cardiovascular disease risk through two key pathways. Dr Dayspring unpacks why it’s so important to test, how to ask for this test, and what to do with your results. Specifically, we discuss: Introduction (00:00) Demystifying Lipoprotein(a): An Overview of its Role in Cardiovascular Health (02:54) Genetic Inheritance Patterns and Variability of Lipoprotein(a) (10:11) Drug Development Strategies for Reducing Lipoprotein(a) Levels (14:50) Exploring the Functional Role and Genetic Variations of Lipoprotein(a) (20:27) Inside the Artery Walls: Mechanisms and Structure of Lipoprotein(a) (32:34) A Deep Dive in Production to Measurement of Lipoprotein(a) (42:32) Identifying High-Risk Indicators for Lipoprotein(a) (58:54) Statins and Elevated Lipoprotein(a): Understanding the Relationship (01:11:42) Exploring PCSK9 Inhibitors in Lipoprotein(a) Management (01:20:30) Emerging Treatments and Future Therapies for Lowering Lipoprotein(a) (01:31:22) Exploring Lifestyle Considerations and Alternative Therapies (01:34:42) Oxidized Phospholipids and Their Role in Cardiovascular Health (01:43:15) Relationship Between Oxidized Phospholipids and Lipoprotein(a) (01:52:00) Understanding Aortic Valve Calcification and Its Link to Lipoprotein(a) (01:59:40) Key Takeaways and Future Landscape of Lipoprotein(a) Treatments (02:06:52) Conclusion and Final Remarks (02:13:30) Connect with Dr Thomas Dayspring on Twitter/X. Listen to our previous lipid series and download the cheat sheet here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #319. Join me today as I sit down with a very special guest: my dad, Professor Michael Hill, PhD. Dad’s journey as a scientist has inspired my own work and taken our family across the globe, and I’m honoured to host him as he shares his story from early career discoveries to current research. As well as getting an inside look at Dr Hill’s academic career, you’ll learn about microvasculature (very small blood vessels), including what they are and how they impact human health. Dad also shares his experience with a heart attack, offers advice on preventing atherosclerosis, and weighs in on the Ozempic and vaping conversations. Specifically, we discuss: Introduction (00:00) Childhood Memories and Early Interests (03:19) Pursuing a Career in Biochemistry (08:36) Microvasculature and Diabetes Research (12:12) Early Research on Investigating Blood Properties and Diabetes (17:44) Family Stories and Moving to the U.S. (28:47) Returning to Australia and Continued Research (36:39) Exploring Microvessel Behaviours: Research at RMIT (41:34) Dealing with Health Challenges and Maintaining Work-Life Balance (46:20) Understanding Microvascular Functions and Cardiac Health (50:32) Exploring Vessel Constriction and Small Blockages: A Closer Look (01:00:15) Understanding the Impact of Large Arterial Stiffness on Vascular Health (01:07:01) Identifying Risk Factors: A Comprehensive Approach to Vascular Well-being (01:11:01) Personal Views on the Evolution of Scientific Research Access (01:19:39) Returning to the USA: Advancing Research on Blood Vessel Mechanisms (01:21:58) COVID-19 and Metabolic Syndromes: Exploring the Early Research Connections (01:27:30) Current Research and Future Directions (01:29:29) Reflecting on a Career Dedicated to Science: Family, Achievements, and Future Directions (01:34:48) If you’re interested in learning more about Dad’s work and career, head to his profile here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #318. 50,000 women. 30 years of follow-up. The results of a new study are in: learn the truth about how your protein intake will affect your long-term health. What kind of protein should you consume? How much? And what difference will it really make on longevity? Today, I’m unpacking the results from the new study in the American Journal of Clinical Nutrition, “Dietary protein intake in midlife in relation to healthy aging - results from prospective Nurses' Health Study cohort”. This new study from researchers at Harvard University and Tufts University has been regularly misinterpreted online, and in this episode, I’ll set the facts straight. Learn the three most important protein takeaways from this study, hear my take on Layne Norton’s interpretation, and crack the code to using protein as a tool for healthy aging. Specifically, I cover: Introduction to Protein and Longevity (00:00) Study Overview and Methodology (01:24) Key Findings on Protein Sources (05:33) Lane Norton's Review and Critique (06:38) Analysis of Different Protein Types (10:02) Practical Recommendations for Protein Intake (17:13) Conclusion and Final Thoughts (21:34) If you’re interested in the Danish Dietary Guidelines, you can find them in English here. This episode is brought to you by: 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #317. Are you neglecting your social health without realising it? We know connection is the often-forgotten pillar of wellbeing and longevity – but how much of a difference does it truly make to your physical and mental health? More than you might think. Join me as I sit down with Kasley Killam, a leading expert in social health, to discover the science behind why relationships are so critical to our well-being. In this episode, Kasley Killam paints a comprehensive picture of the importance of social health and how you can foster it. You’ll learn how connection affects physical and mental health, what good social health is, and how to achieve it. We also discuss what to do about difficult relationships, how to build a strong relationship with yourself, and how to fit intentional connection into a busy schedule. Specifically, we discuss: Introduction to Kasley Killam and Her New Book (00:00) What is Social Health? (03:11) The Importance of Social Health (06:17) Mechanisms Linking Social Health and Physical Health (11:04) Practical Tips to Boost Your Social Health (16:48) Overcoming Challenges & Misconceptions About Social Health (20:44) Personal Practices and Experiments (22:29) Building and Assessing Social Health (34:32) The Decline of Friendships and Social Health (44:32) Impact of Technology on Social Connections (47:10) Work Trends and Social Health (49:11) Public Health and Social Health Innovations (50:12) Fostering Social Health in the Corporate World (54:11) Decode Your Social Health Style (01:00:37) Self-Compassion and Building a Relationship with Yourself (01:15:04) Envisioning a Socially Healthy Future (01:22:08) Conclusion and Final Thoughts (01:23:37) Head to https://www.kasleykillam.com/ to learn more about Kasley Killam’s work and purchase her new book, The Art and Science of Connection. Connect with her on Instagram, Twitter/X, and LinkedIn, and subscribe to her newsletter here. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. Eimele Use code SIMON at checkout for 10% off your first order. 38TERA Use code THEPROOF for a discount at checkout. WHOOP Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #316. Overeating is not your fault. But it is in your control – just not in the way you might think. Learn how to overcome food addiction in this conversation with psychiatrist, neuroscientist, and self-mastery expert, Dr Jud Brewer. Learn Dr Brewer’s secret to gaining control over your eating habits (and no, it’s not willpower). Discover why we overeat, the reason you can’t break bad habits, and how to take back your power over food as we unpack the science of behavioural change. Specifically, we discuss: Introduction: Understanding the Brain and Habit Formation (00:13) Key Elements of Habit Formation (02:55) The Brain's Role in Decision-Making and Habit Change (10:02) The Impact of Awareness and Mindfulness on Habit Change (14:58) Analysing Eating Habits and the Food Environment (24:35) Survivorship Bias in Successful Habit Change (27:36) Emotional Eating and Coping Mechanisms (31:17) Addressing Guilt, Shame, and Systemic Failures (36:24) Environmental Influences on Eating Patterns (41:18) Breaking Negative Eating Habits: Weight Loss Journey (49:00) Effective Strategies to Stop Destructive Habits: Breathwork (58:53) The Role of Psychedelics and Meditation in Overcoming Negative Eating Habits (1:01:24) How the Brain Changes When We Modify Eating Habits (1:04:36) Pharmacology vs. Mindfulness: Which Is More Effective? (1:07:57) Practical Tips to Overcome Night Cravings (1:19:10) Measuring Success in Habit Change (1:28:50) Debunking the 21-Day Habit Formation Myth (1:34:51) Conclusion and Final Thoughts (1:35:54) Connect with Dr Jud Brewer on Instagram, Twitter/X, YouTube, and Threads. Learn more about Dr Brewer on his website, https://drjud.com/, where you can also order his latest book, The Hunger Habit. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com Cozy Earth Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off. Eimele Use code SIMON at checkout for 10% off your first order. 38TERA Use code THEPROOF for a discount at checkout. WHOOP Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #315. What is ApoB and why should you care? In this latest instalment of our masterclass series, I’ve distilled the essential insights about apolipoprotein B (ApoB) into one informative episode. Join top experts including Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho as they unravel the significance of ApoB as a crucial marker of cardiovascular health. This episode provides a thorough understanding of why ApoB matters and how it impacts your health. We unpack the essentials of ApoB, covering its role in cholesterol transport and why it's a key marker for heart disease risk. You'll learn how ApoB affects cardiovascular health, from the way it modifies LDL particles to its impact on atherosclerosis and longevity. We discuss the best ways to measure ApoB, its normal levels, and what causes it to rise. The episode also explores the relationship between ApoB and saturated fats, and why it's a more reliable risk marker than LDL cholesterol. By the end, you'll have a clear understanding of why ApoB matters for your heart health and how it can help guide better health choices. Specifically, we discuss: Introduction (00:00) Lipoproteins & Cholesterol: Transport and Recycling (00:43) Cholesterol's Role in Lipoproteins (26:40) Is ApoB a More Accurate Marker of Cardiovascular Risk? (31:13) Endothelial Transcytosis of Lipoproteins (39:42) LDL Modification and Aggregation (49:17) Evidence for ApoB's Role in Atherosclerosis (55:49) ApoB and Genetics (58:29) ApoB and Longevity (1:02:16) Mechanisms Behind Elevated ApoB Levels (1:05:14) Why ApoB is the Best Predictor of Cardiovascular Disease (1:08:52) ApoB vs LDL-Cholesterol: Understanding the Discordance (1:21:00) Healthy ApoB Levels for Young Adults (1:31:39) Causes of Elevated ApoB Levels (1:45:16) Target ApoB Levels for Cardiovascular Disease Prevention (2:04:31) The History and Evolution of the Lipid Hypothesis (2:07:27) Role of ApoB Lipoproteins in Atherosclerosis (2:10:21) Importance of ApoB as a Cardiovascular Risk Marker and Its Clinical Application (2:18:39) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:27:47) Top Saturated Fat Foods That Increase Cardiovascular Risk (2:33:53) Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:35:49) Dietary Changes to Lower ApoB Levels (2:38:59) Outro (2:45:54) Read more about the guests featured on this episode or connect with them on their respective pages on The Proof website: Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #314. Science tells us we need relationships to live better, for longer. But how do we cultivate our relationships to benefit ourselves and our loved ones? Join me in Episode #314 as I sit down with IN-Q for an exploration of creativity, self-compassion, and empathy. In this episode, you’ll discover why you should learn to be vulnerable and how to do so. We discuss the danger of loneliness and how to improve life satisfaction, why creativity is a crucial practice for everyone, and how you can truly learn from failure. IN-Q also shares some of his poetry as well as key moments in his journey to where he is today. Specifically, we discuss:: Introduction (0:00) IN-Q Performs His Poem “Growth AKA Goldfish” (1:32) The Importance of Emotional Health and Vulnerability (5:48) Does Expressing Emotions Show Weakness? (12:34) The Creative Process and Overcoming Failure (19:06) From Poetry to Platinum Hits: A Diverse Creative Journey (29:19) The Intention Behind Poetry and Empowering Through Creativity (34:40) The Creative Process: Inspiration, Writing, and Reflection (41:57) Finding Play and Presence in Life (47:04) A Poet's Journey: From Personal Struggles to Creative Expression (50:58) Love, Relationships, and the Quest for Connection (1:01:09) Launching "The Never-Ending Now" Poetry Journal and Album (1:12:46) Closing with Empowerment: A Poem of Pride (1:14:06) Outro (1:18:35) Connect with IN-Q on Instagram. His website, in-q.com, is your go-to to learn more, listen to The Never Ending Now album, shop his journal and book, and more. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants

Episode #313. Is your menstrual cycle normal? How is the pill affecting your body? Join me as I sit down with Dr Jen Gunter, a renowned expert in women's health, to answer these questions and many more as we take a deep dive into contraception, the menstrual cycle, and common female health myths. You’ll learn about the key phases of the menstrual cycle and the associated symptoms, discover how different forms of hormonal contraception work and whether they’re safe, debunk a series of pervasive female health myths, and much more. Whether you personally menstruate or use contraceptives or know someone who does – effectively everyone – this episode is an essential listen on female health. Specifically, we discuss: Intro (00:00) The Impact of Disinformation on Women's Health Choices (01:17) Exploring Gaps in Medical Research on Female Physiology (07:17) Navigating Misinformation and Vulnerability in Women's Health (15:52) The Importance of the Menstrual Cycle: A Comprehensive Overview (17:44) Inclusivity and Language in Medical and Social Contexts (33:12) The Phases of the Menstrual Cycle: A Detailed Explanation (41:02) Female Physiology: Mechanism and Function of Menstruation (50:25) COVID Vaccines: Effects on Menstrual Cycles and Fertility (01:01:55) Menstrual Myths Debunked: Separating Fact from Fiction (01:06:00) Managing Menstrual Symptoms and Pain: Expert Advice (01:13:45) Hormonal Health Myths: Dutch Test, Birth Control Pill, and Diet (01:39:33) Osteoporosis and Birth Control Pills: Is There a Connection? (01:46:26) Birth Control and Cancer Risk: Examining the Evidence (01:51:25) Birth Control Pills and Acne (01:57:30) Menstrual Cycle: Detoxification and Birth Control's Impact on Maturation (02:02:03) Emergency Contraception Options: Plan B and Ella (02:08:48) Abortion: Laws, Misconceptions, and Future Implications (02:30:03) Final Thoughts and Empowering Women in Health Choices (02:45:56) Connect with Dr Jen Gunter on Instagram, Twitter, and TikTok. Order her new book, Blood: the Science, Medicine and Mythology of Menstruation, here. For even more comprehensive information, you can read Dr Gunter’s other books, The Vagina Bible and The Menopause Manifesto. Head to her blog, https://vajenda.substack.com/, for frequent newsletters and articles. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Head to insidetracker.com/simon and get 10% off the InsideTracker subscription and any plan. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Watch the episodes on YouTube or listen on Apple/Spotify

Episode #312. Vegan vs. omnivore: learn about the Netflix documentary “You Are What You Eat” and the associated twin study with lead researcher, Christopher Gardner PhD. You’ll learn about why Dr Gardner designed the study the way he did, unpack some key findings, and hear his response to criticisms. From publication, this study gained major media attention that was only amplified by the release of “You Are What You Eat”. With popularity comes criticism, in this case from some big names in online nutrition spaces. Hear the truth about the controversy surrounding this study and documentary, straight from the source. Specifically, we discuss: Intro (00:00) Introduction and background on Christopher Gardner's recent twin study (01:36) Navigating the Challenges of Science Communication and Critique (08:28) Introduction to the Twin Study and Its Unique Design (16:36) The Role of Identical Twins and Defining Plant-Based vs. Omnivorous Diets (22:45) Dietary Patterns and Health Outcomes: The Vegan and Omnivorous Diets (27:25) Diet Satisfaction and Adherence in Nutritional Studies (36:34) The Science of Study Design: Primary vs. Secondary Outcomes (42:05) Responding to critiques on calorie differences (51:58) Cardiometabolic Markers and Diet: A Deep Dive (55:17) Twin Nutrition Study Deep Dive: Lipid Markers, Cardiovascular Risk, and the Impact of Diet (01:00:13) Responding to Critiques (Peter Attia): The Complexity of Diet Studies (01:14:07) Addressing Critique of Mark Hyman (01:29:24) Funding from Beyond Meat and other organisations (01:38:55) Teaching about sustainability and stealth nutrition - Nina Teicholz critique (01:44:29) Is Plant-Based Diet good for the environmental health? (01:48:00) Reflecting on critiques and potential improvements to the study (01:53:47) Personal experience with the Netflix documentary (01:55:45) Outro (01:57:54) Connect with Professor Christopher Gardner on Twitter/X and Instagram. Head to https://nutrition.stanford.edu/ for more resources and studies, and the Stanford Nutrition YouTube channel for more videos. Listen to past episodes featuring Professor Gardner here. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase. Momentous My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Some people follow a ketogenic diet seeking to lose weight, feel more energised, or gain control over their eating habits. Others may turn to this diet in an effort to treat conditions such as epilepsy, bipolar disorder, diabetes and inflammatory diseases. Regardless of their reasoning for adopting this eating pattern, a key question remains: is there ever an instance where having high LDL cholesterol levels on a ketogenic diet can be safe? In Episode #311, I’m joined by Dr William Cromwell, MD and Dave Feldman to explore this question. In this discussion, Dr William Cromwell and Dave Feldman share their professional opinions on whether high cholesterol on a keto diet is a problem. We investigate where their opinions align and where they differ, where Dave’s hypotheses diverge from the norm, and what we do and don’t know with the available evidence. We also explore the significance of ApoB, lifespan and healthspan considerations, research Dave is currently conducting, and much more. Specifically, we discuss: Intro (00:00) Dr. William Cromwell: Background as a Lipidologist and LDL Research (01:54) Dave Feldman's Ketogenic Diet and Elevated LDL Experience (05:34) Unpacking the Lipid Hypothesis and Cardiovascular Risk (12:30) The history and evolution of the lipid hypothesis (20:40) The role of apoB lipoproteins in atherosclerosis (23:39) Factors beyond apoB involved in atherosclerosis and mortality risk (31:59) The complexity of interpreting mortality data in the context of apoB (41:40) Macrophages and the process of atherosclerosis (44:00) Beyond ApoB: Metabolic Vulnerability, Inflammation and Mortality Risk (52:57) Transcytosis: A New Perspective on LDL Movement and Atherosclerosis (1:10:36) Exploring Low Cholesterol Impacts and Genetic Disorders (1:17:30) Macrophage function and phenotype in the context of different drivers of high apoB (1:22:30) Defining Lean Mass Hyper-responders in the Context of a Ketogenic Diet (1:31:40) Investigating PCSK9 and Its Effects on Healthspan (1:38:00) Assessing cardiovascular risk in lean mass hyper-responders (1:43:50) Statin safety, adverse effects, and patient reluctance (2:01:54) Ketogenic Diets and Elevated LDL: Balancing Individual Risks and Benefits in the Absence of Long-term Data (2:10:40) Insulin Resistance, ApoB, and Cardiovascular Risk: Navigating the Challenges in Assessment and Imaging (2:18:12) Lean Mass Hyper-responder Study: Design, Recruitment, and Eligibility Criteria (2:32:45) Closing Perspectives on Research and Dietary Options (3:04:47) Outro (3:06:42) Connect with Dr William Cromwell: Twitter/X, LinkedIn, and https://www.mylipid.com/. Discover more of his work with Precision Health Reports: Twitter/X, LinkedIn, Facebook, Instagram, and at https://precisionhealthreports.com/. Connect with Dave Feldman: Twitter/X, YouTube, and Instagram, and discover more of his work at https://citizensciencefoundation.org/, https://ownyourlabs.com/, and https://cholesterolcode.com/. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Shopify Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Sun Home Saunas Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase.

Episode #310. For many of us looking to achieve athletic goals and age healthily, protein is something that is regularly front of mind. Join me as I sit down with Associate Professor Nicholas Burd, a muscle physiologist and researcher, to discuss the latest scientific evidence on protein. From selecting your protein source to choosing an appropriate amount for your goals, Dr Burd shares recent research findings on how to optimise your protein intake. Discover the nuanced difference between optimising and maximising intake, the problem with eating too much protein, and why getting protein from whole foods is important. We also cover protein timing and distribution, supplementation, and much more. Specifically, we discuss: Intro (00:00) Introduction to Nicholas Burd's Work as a Muscle Physiologist (01:32) Exploring Muscle Protein Turnover and Renewal (03:57) Muscle Fibre Hyperplasia vs. Hypertrophy in Humans (08:06) The Role of Protein Metabolism in Muscle Physiology (15:21) Optimal vs. Maximal Protein Intake for Muscle Growth (19:12) Understanding Amino Acid Oxidation and Its Implications for Muscle Growth (23:05) Leveraging Food Matrix Effects for Optimal Protein Utilisation (33:39) The Role of Dietary Fats in Potentiating Amino Acid Utilisation (38:55) How Low-Carb Diets Influence Protein Requirements (43:50) Protein Requirements During Energy Restriction and Weight Loss (46:54) Optimising Protein Intake for Endurance Athletes (48:08) Nutrient Timing and Protein Distribution (1:05:06) Maximising Dietary Protein Absorption and Utilisation (1:12:34) Protein intake from the perspective of muscle physiologist (1:18:09) Sex-Based Differences in Protein Metabolism with Aging (1:20:45) Should You Supplement With Essential Amino Acids or BCAAs? (1:26:12) Exploring the Rationale Behind Collagen Supplementation (1:30:43) Biggest Protein Myths Debunked (1:40:16) Outro (1:42:45) Learn more about Dr Nicholas Burd on his staff profile, and read his publications on ResearchGate. If you’re interested in learning more about protein, make sure to listen to Episode #290, a protein masterclass featuring world-renowned experts. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. BON CHARGE Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #309. Testosterone: we hear it thrown around constantly as the silver bullet for curing all kinds of symptoms. Join me as I sit down with Dr Adam Hotchkiss, podiatric physician and foot surgeon turned human optimisation specialist, to answer all your burning questions about testosterone, TRT, steroids, and more. This is an important listen for any men considering using steroids to enhance their physique or looking to safely increase testosterone without compromising fertility. We take a deep dive into testosterone in this episode, covering what it is, what’s considered normal and healthy levels in men, and symptoms of low testosterone. Dr Hotchkiss breaks down how lifestyle factors can influence your testosterone, explains how to boost it (and whether you need to), and covers concerns about fertility and heart disease. Specifically, we discuss: Introduction (00:00) Adam Hotchkiss' Journey: From Podiatry to Hormonal Health Optimisation (03:55) Understanding testosterone's functions, symptoms of deficiency, and impact on overall health (12:00) How the body makes testosterone? (20:56) Understanding Total, Free, and Bioavailable Testosterone Levels (24:35) Examining Testosterone Reference Ranges and How They've Changed Over Time (29:46) Role of Oestrogen in Testosterone Replacement Therapy Benefits (38:27) Preserving Fertility While on Testosterone Therapy: HCG and Other Options (48:48) HCG and Testosterone Replacement Therapy (TRT): What You Need to Know (55:17) Testosterone Replacement Therapy (TRT): When Is It Necessary? (1:01:09) Understanding Testosterone Replacement Therapy: Bioidentical vs Synthetic (1:04:56) The Science Behind Steroid Abuse: What Young Men Need to Know (1:12:39) How Does Testosterone Affect Cardiovascular Health? (1:16:02) Optimising Testosterone Levels Through Lifestyle Changes: Nutrition, Sleep, Exercise (1:20:28) Do Testosterone-Boosting Supplements Really Work? (1:33:55) Should You Optimise Testosterone Levels? Case Study and Discussion (1:36:30) Trenbolone Exposed: Exploring the Evidence on Side Effects (1:44:35) Outro (1:54:11) Connect with Dr Adam Hotchkiss on Instagram and learn more on YouTube. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Bon Charge Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #308. How would Jesus kill an animal? Join me as I sit down with filmmakers Kip Andersen and Kameron Waters to discuss their position on how religion and veganism intersect. Whether you are religious or not, there are many interesting points raised to reflect on further. In their new documentary Christspiracy, Kip and Kameron pose the question: is there a spiritual way to kill an animal? In this episode, they argue what they believe to be the accurate interpretation of what the Bible says about animal liberation, taking us on a journey of what the concept of dominion truly means. We discuss a 2000-year-old cover-up, whether eating meat as a Christian is hypocritical, the truth about regenerative agriculture, and much more. Specifically, we cover: Intro (00:00) Unveiling the Truth Behind Religious Misinterpretations (06:06) Exploring the Daniel Fast: A Christian's Journey to Plant-Based Eating (13:43) Connecting the Dots: The Nazarenes, Mistranslations, and Jesus' Controversial Temple Actions (19:07) The Mistranslation of Dominion and Its Impact on Western World Beliefs (25:38) Rethinking Christianity's Relationship with Animal Consumption (31:50) Exploring the Intersection of Spirituality, Ethics, and Filmmaking: A Journey of Discovery (43:52) How the Animal Agriculture Industry Influences Religious Views on Animal Consumption (50:57) Is It Possible to be Spiritual and Consume Animal Products? (1:00:47) Regenerative Farming: A Closer Look at Animal Welfare and Ethics (1:05:07) Examining the Contradictions in Joel Salatin's Ethical Farming Practices (1:12:27) How Different Religions Approach the Consumption and Killing of Animals (1:25:51) Making "Christspiracy": How to Create an Engaging Film About Killing 70 Billion Animals (1:33:42) Outro (1:39:27) Learn more about Christspiracy at https://www.christspiracy.com/. Connect with the Christspiracy community on Instagram, Facebook, YouTube, and TikTok. This episode is brought to you by: InsideTracker If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. 38TERA Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. WHOOP Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Episode #307. According to Robin Sharma, eight factors define wealth – and only one of them is money. Join me in today’s episode as I sit down with this leadership expert and bestselling author to unpack what it truly means to be wealthy. You’ll learn about what happy people have in common, how to find more fulfilment, and how to perform a full reset on your life. Robin pulls back the curtain to offer a glimpse of what his habits look like and how you can implement habits to help you become your best self. Plus, discover why you should consider eating out alone, why you should be thinking about death, and plenty more in this insight-packed conversation. In any conversation considering the relationship between money and happiness, it’s important to note that not everyone has the time or resources to commit to self-improvement. If you’re in this camp, you’re far from alone. My advice would be to take the core principles discussed in this episode and find some goals that are reasonable for you. Even if you can only set aside fifteen minutes a day, any steps you can take have the potential to make a big difference in the long run. Specifically, we discuss: Intro (00:00) How Can Morning Rituals Boost Your Productivity and Creativity | Morning Routine of Robin Sharma (07:07) Gratitude as a Foundation for Wealth (13:46) The Eight Forms of Wealth: Redefining Success Beyond Money (16:19) Beyond Imposter Syndrome: Finding Your Unique Value in the World (25:46) Exploring the Eight Forms of Wealth for a Balanced Life (32:37) Mastering the Art of Listening for Deeper Relationships (43:08) Embracing Solitude, Kindness, and Generosity: The Path to Self-Growth and Empowerment (50:44) Finding Silence and Self: Going Off-Grid for Inner Peace (01:06:52) "I'll try" is a failure strategy... Not a success methodology. (01:12:53) How Resentment Affects Your Life: Overcoming Emotional Baggage (01:14:58) The Power of Minimalism in Reading: Mastering Fewer Books Deeply (01:20:00) Finding Freedom in Writing: Lessons from a Decade of Lost Diaries (01:23:48) How to Journal for Growth? (01:32:26) Can Embracing Our Mortality Change the Way We Live and Work? (01:35:06) Living Your life Fully so You Can Die Empty (01:38:12) Recruiting a Dead Board of Directors for Life-Changing Wisdom (01:39:44) How to Know You're on the Right Path? (01:44:44) Outro (01:46:09) Learn more about Robin Sharma on his website, https://www.robinsharma.com/. Pre-order his new book, The Wealth Money Can’t Buy, here. You can connect with Robin on Instagram, Twitter/X, and YouTube. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Episode #306. How can women build muscle, commit to an exercise program, and manage menopause weight gain? Dr Alyssa Olenick returns today to finish our conversation on exercise and recovery for women, answering these questions and many more. You’ll learn how women should be training differently from men, including what you should implement and avoid. We discuss how to grow your booty, how to tell if you’ve trained hard enough, and how to train regularly. Dr Olenick also covers whether cold water immersion is safe and beneficial, what to do about weight gain during menopause, and what you should be supplementing with. Specifically, we discuss: Intro (00:00) Understanding Sex Differences in Training: Tailoring Workouts for Women (01:59) Mastering RPE for Effective Workouts: A Beginner's Guide (13:16) The Ideal Weekly Routine for Booty Gains: Quality Over Quantity (23:34) How do you know if the workout program is effective? (29:07) Navigating Soreness and Recovery in Strength Training (39:02) Cold water emmerson and reducing muscle soreness (49:03) Navigating the Menopause Conundrum: Understanding Weight Gain and Body Changes (56:21) How Resistance Training Transforms Women's Health During Menopause (1:08:00) Zone 2 Training vs. High-Intensity Workouts: What's Best for Women? (1:17:50) HIIT Explained: Maximizing Benefits with True High-Intensity Interval Training (1:27:02) Demystifying Supplements: What Really Works for Fitness and Recovery (1:35:25) Breaking Myths: The Truth About Women, Hormones, and Strength (1:41:02) Outro (1:44:13) Connect with Dr Alyssa Olenick on Instagram and YouTube, and learn more on her website. You can also listen to The Messy Middle Podcast on Spotify and Apple Podcasts. Make sure to listen to her first episode on The Proof here. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #305. Transform your fitness approach with Dr Alyssa Olenick's expert guidance on female-specific exercise strategies. With most mainstream exercise guidance based on research primarily undertaken on men, this episode offers much-needed insight into how women can optimise their training program. In part one of this two-part series, Dr Olenick brings the research on exercise for women into the spotlight. You’ll learn about how to design an optimal program, including exercise frequency and intensity, what type of training to do, and whether you should be synching training to your menstrual cycle. We also cover when and what to eat, highlighting the importance of carbohydrates, protein, and getting enough calories. Specifically, we discuss: Introduction (00:00) Overview of Alyssa Olenick's Research (04:58) Exploring Gender Disparities in Sports Science Research (07:47) Should Exercise Guidelines Differ for Men and Women? (13:10) Aligning Exercise with Women's Menstrual Cycles: Myth vs. Science (16:50) Is There Sufficient Evidence for Gender-Specific Exercise Recommendations? (21:22) Should You Exercise When Feeling Tired (28:08) Comparing the Benefits: Frequent Moderate vs. Less Frequent Intense Workouts (36:35) Optimal Exercise Strategies for Women (43:15) Combining Cardio and Strength Training: Same Day or Separate? (54:21) The Role of Carbohydrates in Training Effectiveness (58:08) The Impact of Carbohydrate Restriction During Workouts (1:03:35) Identifying Signs of Low Energy Availability (1:06:43) Protein Requirements for Women: How Much Is Needed? (1:14:22) Strategies for Increasing Carbohydrates for Optimal Workouts (1:20:15) Protein Intake Recommendations for the Average Woman (1:24:45) Conclusion (1:32:35) Connect with Dr Alyssa Olenick on Instagram and YouTube, and learn more on her website. You can also listen to The Messy Middle Podcast on Spotify and Apple Podcasts. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #304. Your friends, family, and partner are helping you live longer. Why? And how? Discover the true importance of relationships in this conversation with clinical psychologist and scientist Professor Marc Schulz. In this episode, you’ll learn about how and why relationships are one of the key factors for health and longevity. Professor Schulz breaks down the key results from the Harvard Study of Adult Development, a study that has been running since 1938, and how you can apply these findings to your life. We cover topics including social fitness, income disparity and longevity, how relationships are formed, the importance of intimacy and vulnerability, and how to improve your health by interacting with strangers. Specifically, we discuss: Intro (00:00) Background of Marc Schulz (00:50) The Significance of Qualitative Research in Psychology (04:50) Introduction to the Harvard Study of Adult Development: A Groundbreaking Inquiry into Human Flourishing (11:30) How do You Know if You're Flourishing in Life? (18:56) Key Findings of the Harvard Study of Adult Development (24:19) How Relationships Are Connected with Happiness and Longevity (30:51) Are Good Relationships Linked to Longer Life? (40:15) Importance of Communication and Cultivating Relationships (51:40) Impact of Major Transitions to Social Relationships (1:02:13) Engaging in Social Activities to Improve Social Fitness (1:08:25) How Happiness Has Changed with Technology (1:19:13) Maintaining Connections with Family (1:26:42) Engaging with Strangers: Tips for Starting Conversations (1:30:08) Addressing the Childhood Phrase "Stranger Danger" (1:38:59) Defining Relationships in Different Stages of Life (1:41:29) Growth in Relationship with Oneself vs. Social Relationships (1:52:35) Looking at Human Flourishing at a National Level (1:57:20) Takeaways: Future of Harvard Study of Adult Development (2:03:10) Outro (2:06:51) Discover more of Professor Marc Schulz’s work at https://www.brynmawr.edu/inside/people/marc-schulz. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #303. Two years ago, Axel Schurawlow was finishing his fifth round of chemotherapy. Today, he sits down with me to share the lessons he’s learned from staring death in the face. From reckoning with the delicate nature of our existence to making the most of the time we have left, Axel has a lot to teach about reframing your mindset to live a full life. You’ll learn about what it’s like to hear that you have five days left to live, and how Axel found the strength to fight. Axel explains how your life will change when you lean on the people you love, set goals, and step out of the victim mentality. Regardless of whether you’ve lived a fulfilling life or are just getting started, Axel’s perspective on life might just change yours. Specifically, we discuss: Intro (00:00) Understanding Cancer Diagnosis: Immediate Reactions (01:33) How to Stay Motivated During Recovery (06:52) The Importance of Therapy and Support from Loved Ones (11:28) How a Life-Threatening Diagnosis Can Teach You About Fear and Purpose (19:17) How Do Relationships Contribute to Healing and Growth? (25:53) Why Gratitude and Perspective Matter in Appreciating Life (30:26) Re-evaluating Life's Priorities After a Major Health Scare (37:43) Setting Goals for Health Recovery: Axel Schura's Journey (43:03) The Role of Love and Connection in Leading a Fulfilling Life (51:05) Axel Schura on Embracing Responsibility After Beating Cancer (57:16) The Benefits of Positive Reframing and Taking Self-Responsibility (01:01:33) Building Resilience: How to Overcome Life's Difficult Moments (01:09:50) Nutritional Guidance During Cancer Treatment (01:19:30) Addressing Fertility and Planning for Family After Treatment (01:26:00) Hope and Perseverance: Key Takeaways from Axel Schura's Experience (01:32:33) Connect with Axel and learn more about his story on Instagram, YouTube, through his website, and podcast. Axel is offering The Proof's listeners three months of free access to his online community. To claim, just send a direct message with the keyword “SIMON” to Axel on Instagram. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #302. Learn everything you need to know about fasting from some of the world’s leading authorities. From addressing common myths to offering specific guidance on how to make time-restricted eating work for you, this episode is a masterclass on using fasting as a powerful tool for enhancing health and longevity. This episode features highlights from past episodes with Dr Courtney Peterson, Dr Emily Manoogian, Dr Satchin Panda, and Dr Valter Longo to give you a comprehensive understanding of fasting. We cover everything from the essentials of fasting to its synchronisation with circadian rhythm, the metabolic advantages it offers, and how to implement it for maximum benefit. Specifically, we discuss: Introduction to Time-Restricted Eating and Fasting Concepts (01:39) How Circadian Rhythms Influence Meal Timing (05:46) Exploring the Metabolic Advantages of Time-Restricted Eating (13:52)\ Comparing Late vs Early Time-Restricted Eating Effects (21:17) Comparing Calorie Restriction vs Time-Restricted Eating (24:13) Is Time-Restricted Eating Effective? (36:16) The Breakfast Debate: To Skip or Not to Skip (43:00) Time-Restricted Eating and Exercise Regimens (47:53) Understanding What Interrupts a Fast (50:52) Time-Restricted Eating and Shift Workers (54:26) Latest Insights on Time Restricted Eating: What We Know Now (1:00:40) The Link Between Circadian Rhythm and Time-Restricted Eating (1:04:53) Finding Your Optimal Eating Window for Health and Wellness (1:13:17) Time Restricted Eating and Blood Glucose Management: A Deep Dive (1:25:45) Time Restricted Eating vs. Calorie Restriction (1:32:26) The Connection Between Fasting and Longevity (1:53:38) Gender Differences in Time-Restricted Eating and Fasting Safety (1:56:28) The Science and Benefits of Extended Fasting Periods (2:05:00) Early vs Late Time-Restricted Eating: Findings from a Randomized Controlled Trial (02:08:19) Early vs. Late Time Restricted Eating: Which Is More Effective? (2:16:42) The Effects of Time-Restricted Eating on Appetite Control (2:23:59) How Time-Restricted Eating Affects Blood Pressure (2:26:10) Potential Negative Impacts of Time-Restricted Eating (2:30:50) Investigating the Relationship Between Time-Restricted Eating and Mood (2:32:24) Can Time-Restricted Eating Offer Benefits Without Calorie Counting? (2:33:09) Meal Timing Strategies for Shift Workers (2:35:43) Exploring the Link Between Time-Restricted Eating and Cancer Prevention (2:39:23) Introduction to the Fasting Mimicking Diet (2:47:27) The Fasting Mimicking Diet's Impact on Cancer Management (3:04:09) Outro (3:15:48) Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting checkout–up to 36% better compared to other leading ecommerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Episode #301. Have you started preparing your body for your older years? Or are you already in your older years, wondering how you can best protect yourself from falls and maintain strength and function? Join me as I sit down with Associate Professor Justin Keogh to learn about what sarcopenia is and how you can prevent it. You’ll learn who is at risk for sarcopenia, when to take action to prevent it, and how to move forward if you are facing it already. Dr Keogh identifies the two most important factors for staying strong and mobile, the gold-standard training protocol you should aim for, and other ways you can get the most bang for your buck with exercise. Specifically, we discuss: Intro (00:00) Understanding Sarcopenia: An Overview and Early Signs (01:29) Key Risk Factors and Predictors of Longevity in Sarcopenia (13:15) Muscle Function in Aging: From Centenarians to Muscle Mass Loss (19:18) The Role of Physical Activity in Managing Sarcopenia: Exercise Myths and Facts (25:03) Sarcopenia Across the Lifespan: Gender Differences, Disease Classification, and Causes (35:28) Understanding Muscle Decline with Age: Mechanisms and Muscle Cell Types (43:29) Training for Strength and Longevity: Power Training, Resistance Workouts, and Aerobic Exercises (50:09) Innovative Training Methods: Exercise Snacking, Progressive Loading, and Reducing Muscle Soreness (1:18:51) Optimising Muscle Health: Weekly Training Protocols and Body Adaptation to Exercise (1:39:32) Hormones, Supplements, and Lifestyle Strategies for Sarcopenia Management (1:48:20) Addressing Sarcopenia: Gender Differences, Causes, and Weight Management (1:53:36) Debunking Myths and Shaping Future Guidelines for Sarcopenia Prevention (2:10:45) Outro: The Path Forward in Sarcopenia Research and Awareness (2:14:50) Learn more about Associate Professor Justin Keogh on his Bond University profile, read his publications on ResearchGate, and connect with him on Twitter/X. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. People all over the world are using Reveri to quit smoking, gain control over other addictions, reduce physical pain, feel more relaxed, and improve their mental health. The Proof community members can use Reveri for 30 days free with a guest pass. Just visit reveri.com/theproof to redeem.  Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #300. How does body image fit into our picture of overall health? When does negative self-image become body dysmorphic disorder? And does veganism align with a positive relationship with food? Discover the answers to these questions and many more in this conversation with Associate Professor Gemma Sharp. You’ll learn about body dysmorphic disorder (also called body dysmorphia), who falls into this category, and who is at risk for it. We discuss the impact of social media on body image, the prevalence and treatment of eating disorders, and harmful trends in the media. You’ll also discover the facts about body image in vegans, cosmetic interventions, and how AI might be the answer to overwhelmed mental health services. Specifically, we discuss: Introduction (00:00) Exploring Interest in Body Dysmorphic Disorder with Gemma Sharp (01:35) Understanding Body Dysmorphic Disorder: Definition, Prevalence, Onset, and Causes (04:20) The Influence of Social Media on Body Image (09:01) The Role of Social Media in Seeking External Validation (12:33) Managing Social Media's Impact on Body Image: Advice for Parents (18:08) Practising Self-Compassion: The Compassionate Friend Exercise (20:03) Effectiveness of Positive Self-Talk in Body Image Improvement (23:32) Connection Between Eating Disorders and Body Dysmorphic Disorder (25:35) Navigating Eating Disorders: Orthorexia, Anorexia vs Bulimia, Impacts Across Weight Spectrums, and Screening Tools (26:32) Identifying Triggers for Developing Eating Disorders (31:02) Harmful Media Trends Leading to Eating Disorders (33:14) Medical Approaches to Treating Eating Disorders (34:41) Comparing Dietary Patterns: Vegan vs Omnivorous Diets in Eating Disorders (38:04) Evidence-Based Strategies for Treating Eating Disorders (43:36) The Role of AI in Treating Eating Disorders (49:10) Debunking Myths About Eating Disorders (53:48) Eating Disorders in Athletics: The Interplay with Exercise (55:02) Cosmetic Procedures and Body Image: Mental Health, Satisfaction, and Safety (1:02:05) Insights into Labiaplasty from a Scientific Perspective (1:10:05) Empowering Education: Understanding Female Anatomy and Overcoming Social Taboos Understanding Male Motivations for Penile Augmentation (1:23:35) Concluding Remarks (1:27:38) Learn more about Associate Professor Gemma Sharp here, and connect with her on Twitter/X. Visit The Proof website for the full show notes and supporting studies. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high-protein Plant Performance recipe book

Episode #299. Could psychedelics be the answer to the mental health crisis? Join me as I sit down with psychologist and academic, Dr Stephen Bright, to examine the prevalence of drug usage, what this means in the context of mental health, and how psilocybin and MDMA might be the future of mental health treatment. You’ll learn about the most common drugs in Australia, including cannabis, cocaine, MDMA, and psychedelics. We discuss how these drugs are portrayed in the media, why workplace drug screening may be harmful, and current and upcoming research in the field of psychedelics as a medical treatment option. Dr Bright also shares his views on how decriminalisation and legalisation can help protect vulnerable people. Specifically, we discuss: Introduction to the Podcast (0:00:00) Stephen Bright: Journey into Psychedelic Research (0:01:24) Trends in Drug Use Across Australia and Western Nations (0:06:52) Detecting Cocaine and Cannabis: Health Impacts (0:15:56) Legal Status of Synthetic Cannabis (0:18:35) Cannabis Usage Trends: Analysis (0:20:45) Vaping vs Smoking: Health Perspectives (0:28:10) Impact of Drug Use on Mental Health in Australia (0:31:26) Current Mental Health Treatment Approaches (0:37:07) Exploring Entheogens and Psychedelics (0:47:35) Academic Advancements in Psychedelic Research (0:49:58) Efficacy of MDMA and Psilocybin in Therapy (0:57:40) Psychedelic Research: Australia's Journey (1:11:02) Understanding Psychedelic Scepticism (1:17:17) Intersection of Psychedelics and Religious Practices (1:23:22) Psychedelics and Spiritual Awakening (1:27:12) Current Psychedelic Research Trends in Australia (1:29:34) Evolving Treatments for Mental Health Conditions (1:33:00) How Legalising Psychedelics Could Influence Drug Use (1:36:32) Psychedelics in Preventative Mental Health Strategies (1:38:35) Decriminalisation vs Legalisation of Psychedelics: A Comparative Analysis (1:41:28) Wrap-Up: Key Insights and Conclusions (1:56:40) Connect with Stephen Bright, PhD on LinkedIn and Twitter/X. Discover more of his work on Prism, Psychedelic Institute Australia (for healthcare practitioners), Students for Sensible Drug Policy, and AOD Media Watch. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  People all over the world are using Reveri to quit smoking, gain control over other addictions, reduce physical pain, feel more relaxed, and improve their mental health. The Proof community members can use Reveri for 30 days free with a guest pass. Just visit reveri.com/theproof to redeem. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #298. Ever wondered why you just can’t stop eating certain foods? Psychologist Tera Fazzino, PhD has the answer. Discover the science of hyper-palatable foods, how they’re making their way into your kitchen, and where they overlap with the tobacco industry in this insight-packed conversation. You’ll leave this episode with a better understanding of why hyper-palatable foods are so prevalent, what to look out for, and how you can better navigate the grocery store. Dr Fazzino also breaks down the policy-level change she would want to see to create a healthier food landscape for everyone. We cover: Introduction to Hyperpalatable Foods and Brain Reward Systems (00:00) Exploring Brain Reward Mechanisms Triggered by Hyperpalatable Foods (02:45) The Influence of Hyperpalatable Foods on Brain Reward Functions (12:58) Food Addiction Explored: A Psychological or Physical Issue? (17:01) Identifying Susceptibility Factors in Food Addiction (20:59) The Impact of Mental Health on Consuming Hyperpalatable Foods (23:44) Comprehensive Analysis of Hyperpalatable Foods and Their Ingredients (26:38) The Critical Role of Sodium in Food Palatability Enhancement (30:27) Debating the Reduction of Sodium Consumption: Benefits and Challenges (35:26) The Intriguing Connection Between the Tobacco and Food Industries (45:52) Are All Ultra-Processed Foods Created Equal? A Critical Examination (58:24) Identifying Hyperpalatable Foods Commonly Found in Homes (1:04:48) Protein's Interplay with Hyperpalatable Foods: A Detailed Study (1:09:39) Examining Caloric Intake and Overeating Tendencies with Hyperpalatable Foods (1:16:48) Unveiling the Hidden Mechanics of Hyperpalatability: Satisfaction vs. Energy Density (1:19:18) Practical Strategies for Managing Hyperpalatable Food Consumption (1:22:59) Global Health Impacts of Hyperpalatable Foods: An In-Depth Review (1:28:39) Future Trends in Food Policy and Public Health Concerning Hyperpalatable Foods (1:33:18) Replacing Sugar with Artificial Non-Nutritive Sweeteners: Pros and Cons (1:41:11) Concluding Remarks on Hyperpalatable Foods and Health (1:44:14) Learn more about Dr Tera Fazzino here, and discover her lab at https://fazzinolab.ku.edu/. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting checkout–up to 36% better compared to other leading ecommerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. People all over the world are using Reveri to quit smoking, gain control over other addictions, reduce physical pain, feel more relaxed, and improve their mental health. The Proof community members can use Reveri for 30 days free with a guest pass. Just visit reveri.com/theproof to redeem. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Episode #297. Think hypnosis is for stage shows and witches? Think again. Learn from Stanford Professor David Spiegel about how this revolutionary treatment approach can help break bad habits, manage pain, and improve a range of conditions from insomnia to IBS. You’ll learn what clinical hypnosis is, how it works, and how it differs from meditation. Dr Spiegel also addresses some common fears and misconceptions about this practice, explaining the research and how it fits in with psychotherapy and clinical guidelines. Tune in to discover whether hypnosis might be a good approach for you and how to get started. Specifically, we discuss: Intro to Hypnosis with Stanford's David Spiegel (00:00) Exploring Hypnosis with Stanford Professor David Spiegel (01:53) The Science of Hypnosis Demystified (09:12) Examples of Hypnosis in Smoking Cessation (13:17) Clinical Hypnosis: Control and Perspective Shift (18:10) Pain Management Through Hypnosis (21:46) Hypnosis in Treating PTSD and IBS (30:33) Role of Hypnosis in Psychiatry and Scientific Research (36:44) Are You Hypnotizable? (43:31) Hypnosis and Meditation: Understanding the Differences (48:27) Efficacy of Hypnosis via Apps: Usage and Advice (56:52) Enhancing Sleep Quality with Hypnosis: 1:01:34 Exploring Psychedelics in Trauma Therapy: 1:06:29 Integrating Hypnosis in Psychiatric Treatments: 1:10:37 Evolving Perception of Hypnosis in Medical Community: 1:16:25 Hypnosis and Meditation: Key Differences and Benefits: 1:17:38 Hypnosis vs. Opioids: Safety and Efficacy Compared: 1:19:27 Conclusion: The Future of Hypnosis: 1:24:55 Connect with Professor David Spiegel through the Reveri platforms on Instagram, YouTube, Twitter/X, and LinkedIn. Learn more about Reveri and download the app at https://www.reveri.com/. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.  Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting checkout–up to 36% better compared to other leading ecommerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #296. Looking to lose weight and gain muscle with science-backed insights? Tune in to this conversation with nutrition researcher Alan Aragon to unpack the nuances of achieving optimal body composition. You'll gain a deeper understanding of how to effectively use nutrition – balancing calories, protein, fats, carbohydrates, and even alcohol – to enhance your physique. Discover the crucial role of resistance training, the importance of supplementation, and the myths around fasting and keto diets in muscle building and weight loss. Alan's expertise will empower you with practical, science-backed strategies for sustainable body composition changes, whether you're looking to lose weight, build muscle, or both. Specifically, we discuss: Introduction to Body Composition and Fitness Science (00:00) How Alan Aragon's Passion for Fitness Shapes His Evidence-Based Approach (3:34) Debunking the Anabolic Window: Fact or Fiction? (7:32) Impact of Meal Timing on Body Composition: A Scientific Analysis (12:28) Comparing Fasted vs. Fed Resistance Training for Muscle Growth (22:51) Understanding Amino Acids in Muscle Protein Synthesis (25:38) Protein Needs Across Ages: A Comprehensive Guide (32:16) Evaluating Amino Acid Supplementation at Varied Protein Intakes (39:16) Calculating Optimal Protein for Different Age Groups and Body Weights (41:53) Linking Protein Intake with Body Recomposition: A Scientific Perspective (47:33) Methods to Determine Your Fat-Free Mass Accurately (58:12) Muscle Building: Ketogenic Diet vs. High Carbohydrate Diet (1:02:04) Energy Balance vs. Carbohydrate-Insulin: Diet Models Explored (1:08:03) Keto Adaptation and Insulin's Role in Weight Loss Explained (1:13:40) Investigating the Rise in Overweight and Obesity Since the 1960s (1:23:33) Optimal Fat Loss Strategies: A Science-Based Step-by-Step Guide (1:30:58) Does Starvation Affect Metabolic Rate? Scientific Insights (1:39:30) Integrating Fasting into Your Weight Loss Strategy (1:47:11) Personalising Diet Plans: The Flexibility of Dieting (1:52:53) Protein Intake and Longevity: Finding the Optimal Balance (1:55:26) Soy Protein: Health Benefits and Controversies (1:58:00) Protein Sources and Their Impact on Cardiometabolic Health (2:07:55) Tailoring Weight Loss Programs for Maximum Satiety and Effectiveness (2:15:17) Examining the Safety of Intermittent Fasting for Women's Hormonal Health (2:22:53) Effective Supplements for Enhancing Body Composition (2:30:44) Alcohol's Impact on Body Composition: Key Facts You Should Know (2:36:27) Conclusion and Key Takeaways from Our Fitness Science Discussion (2:44:21) Connect with Alan Aragon on Instagram and Twitter. Head to his website, https://alanaragon.com/, to learn more about his work, purchase his books, or subscribe to his newsletter. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Stay hydrated with LMNT - a meaningful dose of electrolytes in a science-backed ratio. Receive a free LMNT sample pack with any order when you purchase via drinklmnt.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.

Episode #295. Set yourself up for success in 2024 with the next instalment of The Proof’s 2023 highlights. Recap key points for physical and mental health success, from aging and exercise to climate change and psychology. This episode offers a comprehensive rundown from some of the best scientists and experts in the game. You’ll hear from Dr Matt Kaeberlein, Dr Andrew Steele, Dr Charles Brenner, Dr Inigo San Millan, Drew Harrisberg, Dr Susanna Soeberg, Dr Stacy Sims, Chris MacAskill, George Monbiot, Jillian Turecki and Dr Judson Brewer. Specifically, we discuss: Intro (00:00) Understanding Aging: Definitions and Key Hallmarks (01:21) Introduction to Senolytics: What You Need to Know (15:18) The Science of Cellular Aging: Causes and Effects (29:14) Decoding Energy Zones: Insights and Implications (41:36) Effective Workout Strategies: Using Target Heart Rate (53:56) Tailored Training: Menstrual Cycle Considerations for 30-Year-Old Women (1:09:53) Beginner's Guide to Cold Water Immersion: Techniques and Benefits (1:41:00) The Subtleties of Hydration: What Matters Most (1:49:50) Electrolytes and Hydration: Understanding Their Role (1:52:47) Food and Environment: Analyzing the Impact (1:57:50 ) Beef Consumption: Health Implications and Facts (2:04:06) Carbon Opportunity Costs: Debunking Common Misconceptions (2:08:22) Cultivating Self-Love: Practical Approaches (2:15:22) Navigating Romantic Relationships and Loneliness: A Comprehensive Look (2:20:22) The Human Brain Explored: Comparing Old and New Perspectives (2:24:32) Habit Change Strategies: Effective Techniques (2:28:55) Outro (2:40:16) Learn more about today’s guests and listen to previous episodes via the full show notes. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #294. Hit the ground running in 2024 by pressing play on this must-listen episode. Hear the most valuable insights from 19 guests of The Proof, all packed into one episode that brings you the best of each one. 2023 was absolutely loaded with expert advice from some of the best researchers and practitioners in the world, and this episode combines many of them to bring you a powerful tool to have in your arsenal. This episode will take you on a curated journey through 2023’s most important moments, including the must-knows about nutrition, fats, cardiovascular health, metabolic health, cancer and nutrition, and gut health. You’ll hear from: Dr Alan Flanagan, Dr Ayesha Sherzai, Dr Christopher Gardner, Dr Dena Sherzai, Dr Gil Carvalho, Dr Inigo San Millan, Dr Joel Fuhrman, Dr Krystle Zuniga, Dr Matthew Nagra, Dr Mohammed Alo, Dr Neil Iyengar, Dr Philip Calder, Dr Roy Taylor, Dr Stephan Guyenet, Dr Suzanne Devkota, Dr Thomas Dayspring, Dr Urvi Shah, Dr Walter Willet, and Dr Will Bulsiewicz. We discuss: Intro (00:00) The dangers of misinformation (01:30) Which Foods Should You Eat to Stay Healthy? (05:17) Does the Quality of Foods Matter? (07:38) The Impact of the Average American Diet on Health (09:28) Do We Have Sufficient Evidence on How Nutrition Impacts Our Health? (12:04) How different diets measure up to health guidelines (15:11) Practical insights for doctors and patients (23:08) Saturated fat misunderstandings: Is saturated fat bad? (25:32) Understanding Essential Fats: Why are They Vital? (30:18) Low Conversion Rates: From ALA to EPA & DHA Explained (34:29) The Importance of Monitoring Omega 6 Intake (39:52) Keeping the brain healthy with omega 3 fatty acids (43:45) Biochemical Analysis in Three Cohort Observations of Walter Willet's Studies (56:54) Are Low-Fat Diets Good for Cardiovascular Health? (01:02:12) Polyunsaturated Fats and Cardiovascular Disease (01:04:14) Benefits of Switching from Saturated Fat to Unsaturated Fats (01:09:51) Which popular diets are truly heart-healthy? (01:10:23) Atherosclerosis and the role of lipids (01:18:22) The tests helpful in predicting cardiovascular disease risk (01:31:24) Cardiac Imaging: Understanding Imaging Tests (01:43:34) Can we take drugs that raise HDL to lower cardiovascular disease risk? (01:52:17) Metabolic Health, Mitochondria, and Nutrition (02:00:37) Twin cycle hypothesis (02:07:17) Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:18:56) How Weight Reduction Can Be Revolutionary in Reversing Diabetes (02:31:36) Main drivers of type 2 diabetes (02:38:56) The role of nutrition in cancer treatment (02:45:56) Plant-based diet vs ketogenic diet (02:50:12) Can food act as medicine? (02:55:54)\ Nutrition priorities during cancer treatment (03:05:36) Dietary patterns and FODMAP intolerance (03:08:33) Effects of antibiotics to gut the microbiome (03:16:41) Analysing Kevin Hall's Research: Plant-Based Diet vs. Alternative Diets (03:23:37) Outro (03:33:38) To connect with this episode’s featured guests, head to the full show notes. Make sure to keep an eye out for part two of this series. Sponsors: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.

Episode #293. What can health-conscious people learn from the Seventh-day Adventist Church? Join me as I sit down with Distinguished Professor Gary Fraser, a cardiologist and leading nutrition scientist, to discover the science on why Seventh-day Adventists have better health outcomes. You’ll learn key highlights from Professor Fraser’s 40+ year research and practice career, including BMI and mortality in the Adventist population, the risks and benefits of dairy consumption, omega 3s, and a variety of other health indicators. We also evaluate the key differences between omnivore, pescatarian, vegetarian, and vegan diets, and examine the conspiracy theories that are often projected onto this population. We discuss: Intro (00:00) Discovering Gary Frazier's Scientific Career (02:04) What Influences a Scientist's Change of Mind? (08:17) How to Avoid Bias in Nutritional Data Analysis (15:07) Exploring the Seventh-Day Adventist Perspective on Nutrition and Lifestyle (20:46) Investigating Longevity in Vegetarians and Non-Vegetarians within the Seventh-Day Adventist Community (25:13) Comparing Health and Longevity: Seventh-Day Adventists vs Average Americans (29:59) Analysing Body Weight Differences: Adventists vs Typical Americans (33:30) Muscle Mass and Bone Density: Insights from the Seventh-Day Adventist Population (39:38) The Impact of Protein Consumption and Physical Activity on Strength (44:16) Dietary Variations Among Seventh-Day Adventist Women and Men (48:14) Evaluating the Risks and Benefits of Dairy Food Consumption (51:35) The Impact of Long-Term Diets on Health (1:05:15) Omega 3 Supplementation vs Fatty Fish: What Does Research Indicate? (1:07:19) An Introduction to the Seventh-Day Adventist Church (1:09:00) Uncovering the Story of John Harvey Kellogg (1:12:56) Exploring the Link Between Plant-Based Diet Patterns and Reproductive Health (1:16:36) The Role of the Seventh-Day Adventist in the Battle Creek Sanitarium (1:20:58) Gary Frazier: A Scientist Embracing Seventh-Day Adventist Beliefs (1:24:58) Addressing Major Criticisms of Gary Frazier's Nutrition Research (1:30:24) Diet Comparisons: Adventist Vegetarians vs EPIC-Oxford and British Vegetarians (1:34:49) Assessing Diet Quality in Adventists: Vegans, Vegetarians, and Non-Vegetarians (1:39:31) The Role of DNA Methylation in Diet and Health (1:44:26) Identifying Main Mechanisms Behind Health Outcomes (1:47:03) Investigating Dietary Patterns in Adventists: A Study on Lupus Correlation (1:48:55) Delving into Additional Research on the Seventh-Day Adventist Diet (1:52:08) What Does Adventist Diet Research Reveal About Dairy? (1:54:53) Identifying the Most Significant Dietary Change for American Health and Longevity (2:00:53) Where is the Future Heading in Diet Studies for Ultimate Human Health? (2:05:10) Outro (2:10:59) This episode is brought to you by: If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon. Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order. Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon. Simon Hill, MSc, BSc (Hons) Creator of theproof.com Author of The Proof is in the Plants Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book