Author Michael Marshall (@m_c_marshall) joins Matt and Andy to talk about his new book The Genesis Quest, which explores the century-long effort to understand how life began on Earth and the many interesting characters who dedicated themselves to solving this massive scientific puzzle. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian John Hastings (@thejohnhastings) joins Andy and Matt to talk about the questionable comedy of Roy Chubby Brown, neanderthal genes and covid-19, water bodies under the surface of Mars, and using balanced rocks to increase nuclear safety. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably  

Comedian Gene Pompa (@genepompa) joins Matt and Andy to discuss methanol-fueled robot beetles, super long words, methylated alcohol, why the moon is rusting, smartphones knowing when you're drunk-walking and corn that makes its own mucus.

The gang's back together to celebrate 400 episodes of Probably Science! Erstwhile hosts Jesse Case (@jessecase) and Brooks Wheelan (@brookswheelan) join Matt and Andy to discuss counting magicians, Jesse's proximity to train tracks, Ig Nobel prizes for alligators on helium and narcissist eyebrows, detecting phosphine in the clouds of Venus, finding super old sperm in amber, an earthquake hack to measure ocean warming and podcast recommendations including Our Fake History, Entry Level and Jesse vs. Cancer. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Jesse Case rejoins the show for a cancer special with science writer Dr. Kat Arney (@Kat_Arney), author of Rebel Cell: Cancer, Evolution, and the New Science of Life's Oldest Betrayal. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian Jen Burton (@jensburpin) joins Matt and Andy to discuss Africa getting rid of wild polio, painting turbine blades to save birds, a Jeopardy furry champ, an uncuttable material and Idyllwild's very good boy Mayor Max.

Mia Jackson (@miacomedy) join Matt and Andy to talk about old-time casino heists, asteroids that are the greatest basketball player of all time, ancient Americans, songbirds warming up and 100-million-year-old microbes that are still alive. Check out Mia’s performances on Unprotected Sets on Epix, and her Comedy Central half hour. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Despite a technical glitch, the excellent Adam Cayton-Holland (@CaytonHolland), star of Those Who Can’t, the new podcast The Grawlix Saves The World, and his new album Semblance of Normalcy, talks with Andy and Matt about the word stentorian, Earth’s magnetic anomaly, scientific collaborations and X shapes in the galaxy, finding out there's more than one foot, the threat of swooping magpies and what, exactly, ropey means. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Writer, actress and story coach Lynn Ferguson (@lynnfergy) joins Matt and Andy to talk about house snooping and fountain misuse, chickens, wasps in figs, coyote melons, spying on penguin poop, Andy's hiking discovery, painting eyes on cow butts and whether hot water freezes faster than cold. Check out Michelle Biloon’s album Permanent Hat and Sara Schaefer's book Grand!

Matt’s Last Comic Standing buddy (and Season 5 winner) Jon Reep @jonreep joins Matt and Andy to talk about getting COVID, meteors and moons, Shazam for spiders, anus-escaping water beetles, unusual places to grow a penis, medieval antibiotics, Jon's new podcast Country-ish and this totally independent, unbiased ranking of podcasts that we hope to break. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Improv and comedy acting legend Mike McShane (@thismikemcshane) joins Matt and Andy to talk about the funniest kind of nudity, cognitive impairment tests, the limits of human eating, the star that's hurtling across the universe, a sperm robot story we've done before, and mathematicians boycotting the police. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian Jonah Ray (@jonahray), host of Jonah Raydio and co-guest with Matt on TONIGHT'S episode of The Great Debate on Syfy, talks about his great Seeso show Hidden America, taking over MST3K (and his favorite episode), how flying snakes fly, hungry hungry black holes, Twitter hacks and Bitcoin scams, talking to prairie dogs and the coming population crash. This episode is brought to you by StartAPod, providing our listeners with a special offer by visiting StartAPod.com/probably

Comedian Steph Tolev (@StephTolev) joins Andy and Matt from Toronto to discuss quarantining and TikTok-ing with her family, the history of sled dogs, a black neutron star discovery, putting sheep in K-holes and a $23 million space toilet.

Comedian and host of the outstanding podcast Scattered Chris Garcia (@_chrisgarcia) joins Matt and Andy to discuss getting a little too much parental help with science fair projects, dolphins using tools, 3D printing inside the body and how burning coal 250 million years ago led to climate change. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian, swimmer and math major Matthew Broussard (@mondaypunday) joins Andy and Matt to talk about linear algebra, swimming, neanderthal DNA, DNA degradation, Alex Falcone's NASA career, ancient Irish one-percenters, twins marrying twins and twin paternity tests. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian Jake Johannsen (@Jakethis) of the podcast Jake This joins Andy and Matt to discuss an herbal would-be COVID-19 remedy out of Madagascar, why men and women experience alcohol differently, alcohol's lack of protection against COVID-19 and appearing on Dr. Katz.

Comedian and actor Dan Oster (@dernerster) joins Matt and a normally voiced Andy to discuss pantomime dwarves, a desert update, neutron stars showing their cores, a porn star and a toad-venom death, psychological pain treatments, tripping on nutmeg and Dan's A Podcast, But Evil. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Friends of the show Sarah Morgan (@sarahlmorgan) and JJ Whitehead (@JJWhitesnake) return to talk with Matt and a strangely deep-voiced Andy about a USB stick to protect you from the evils of 5G, controlling monkey minds via ultrasound, a super-deep octopus and monkeys stealing coronavirus samples. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedian, actor and voice performer extraordinaire Carlos Alazraqui (@carlosalazraqui) joins Matt and Andy to talk about what you can learn from hundreds of skydiving jumps, mud flows on Mars, laughing gas from penguin poop, a worm that survived being frozen for 41,000 years and Carlos' new movie Witness Infection.

Comedian Kristin Key (@thekristinkey) joins Matt and Andy to talk about her new album Keeper of Feelings, the importance of moths, illicit surfing in bioluminescence, neon dolphins, Pluto's haze, SOFIA, thirsty koalas licking trees and rain caused by nuclear testing. This episode is brought to you by StartAPod, offering our listeners 50% off the first year of a monthly or annual subscription by visiting StartAPod.com/probably

Writer Scott Vrooman (@mescottvrooman) joins Matt and Andy to discuss watching rocket launches, Trident missile tests, what it actually takes to make a ventilator, murder hornets, how to give CPR, the psychological health of vegetarians and meat-eaters, girlfriends' effects on risk-taking and the new Quibi show Memory Hole. This episode is brought to you by The Great Courses Plus, offering our listeners a free trial by visiting TheGreatCoursesPlus.com/probably This episode is brought to you by StartAPod, offering our listeners 50% off the first year of a monthly or annual subscription by visiting StartAPod.com/probably

Erstwhile Probably Science cohost Jesse Case (@jessecase) of Jesse vs. Cancer fame returns (remotely) to discuss everyone's new living situations, what the old Bluebell house looks like now, Andy's neighbor's text, a new LIGO discovery, bird brain sizes, a black paint that somehow cools buildings and analyzing whether farts can spread coronavirus. This episode is brought to you by The Great Courses Plus, offering our listeners a free trial by visiting TheGreatCoursesPlus.com/probably This episode is brought to you by StartAPod, offering our listeners 50% off the first year of a monthly or annual subscription by visiting StartAPod.com/probably

Writer Sam Pasternack (@SamPasternack) of The Podcasternack joins Matt and Andy while riding his quarantine exercise bike to discuss the real toilet paper problem, bomb tests and whale shark ages, a VERY personalized toilet, an unexpected downside of planting trees, a Mercury mission that just got underway and a five-year time lapse of its path to Mercury orbit. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners three months of unlimited access for only $30 by visiting TheGreatCoursesPlus.com/probably

Comedian/actor Danny Jolles (@DannyJolles) joins Andy and Matt to discuss celebrity centers, political science, the astrophysicist who got magnets stuck up his nose, arm hickeys, mouse emotions, finding Clooneys when stressed, neanderthal fishing, ancient Australian fossils, wrestler Mae Young, Danny's podcast Everything But The Scores and Brooks' ridiculous one-man hungover marathon. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners three months of unlimited access for only $30 by visiting TheGreatCoursesPlus.com/probably

Comedian Grant Lyon (@grantlyon1) returns to the podcast on the heels of the release of his new album "Scheduled Fun Time" to talk about "Imagine" parodies, a Mars lander hitting itself with a shovel, NASA accepting applications, genetically modified neurons and implants, Earth's tiny new moon, Grant's astronaut neighbor and an animal that doesn't need oxygen to survive.

Dr. Barry Fox is a Clinical Professor of Infectious Disease at the University of Wisconsin School of Medicine and Public Health. He also teaches An Introduction to Infectious Diseases on The Great Courses Plus, which turns out to be a very timely lecture series right now. Dr. Fox talks with Matt and Andy about infectious disease in general, and COVID-19 in particular, while helping clarify what we do and don't know about the pandemic in which we find ourselves. For up-to-the-minute coronavirus information, Dr. Fox recommends the CDC, the New York Times and the Wall Street Journal. Visit TheGreatCoursesPlus.com/probably to access Dr. Fox's course and hundreds of others.

Comedian/actor Langston Kerman (@LangstonKerman, Insecure, South Side, Bless This Mess) joins Matt and Andy for a COVID-19 quarantine edition of the podcast, discussing oceanography, subterranean chlamydia, raining molten iron, bike speed records, tiny dinosaurs, mammoth bones, forbidden fruit and insect butter. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free month of unlimited access by visiting TheGreatCoursesPlus.com/probably

Comedians Sharon Mahoney (@sharonmahoneyca) and Byron Bertram (@byronbertram) join Matt and Andy to discuss glowing amphibians, COVID-19, Pence's spotty record, the Halifax Explosion and molecular oxygen being found beyond the Milky Way. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free month of unlimited access by visiting TheGreatCoursesPlus.com/probably

Barry Rothbart (@barryrothbart) returns to Probably Science eight years after his last appearance to discuss Scorcese films, Mad Mike Hughes, an autism apology, COVID-19, relative risks and vaccines, expensive cars and being a dick, electricity from thin air, seatbelt laws and lives saved and bomb-sniffing locusts.

Video game writer/narrative director and VR advocate Rob Yescombe (@robyescombe) joins Matt and Andy to discuss 90s computer games on TV, Gamesmaster with Take That, Oculus Quest, inside-out tracking, parallax, light field cameras, volumetric video capture, Surinder Rattan's The Lick, making the VR whodunit The Invisible Hours and the game RiME. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free month of unlimited access by visiting TheGreatCoursesPlus.com/probably

Writer/producer Krister Johnson (@KristerJohnson) joins Matt and Andy to discuss his hilarious new Netflix show Medical Police, God's Pottery, Matt LeBlanc and a very specific accent, virus-naming, radiation-eating fungi, autism and myelin, extreme knitting and walking sharks.

Comedian Ed Salazar (@edasalazar) joins Andy and Matt to talk about the new Goop show, Marianne Williamson's disease theories, yoga scammers, Catholic workouts, Einstein being right again, Mercury retrograde explained, YouTube Wired experts, dorking out on musical intervals, more giant horrendous creepy-crawlies, the upcoming show The Great Debate and koala balls. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners three months of unlimited access for only $30 by visiting TheGreatCoursesPlus.com/probably

Comedian Tiffany Stevenson (@tiffstevenson) joins Matt and Andy to talk about loads of Australian spiders and how to catch them, more drop bear nonsense, Vesuvius turning brains to glass, alcoholic spines, eating too many Australian cakes, Dr. Heimlich and cuttlefish VR.

Alice Fraser (@aliterative, Tea With Alice, The Last Post) sits in as guest co-host for this chat with Comedy Store Players veteran and Whose Line Is It Anyway cast member Richard Vranch (@richardvranch), who more importantly for us is Dr. Richard Vranch, former physicist, for talk about the early days of UK comedy, and his experiments with silicon chips and radiation.

While on the road, Matt talks to Dr. Damian King about his work as the head of Neutral Beam Injection for the JET (Joint European Torus) at the Culham Centre for Fusion Energy and why heating things to 30 million degrees isn't nearly enough. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners three months of unlimited access for only $30 by visiting TheGreatCoursesPlus.com/probably

Comedians Kate Kennedy (@TheOGKennedy) and TJ Chambers (@tjchambersLA) join Andy to discuss physics for poets, Feynman memoirs, family trips and home movies, record-breaking geysers, blood waterfalls and freezing water at its boiling point. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access to thousands of lectures by visiting TheGreatCoursesPlus.com/probably

Writer/comedians TJ Chambers (@tjchambersLA) and Jordan Morris (@Jordan_Morris) return to the podcast to wrap up the decade that was the 2010s, covering things along the way including penis fish, the cat that says "well, hi!", the biggest scientific happenings of the decade, Karen Gillan's box office dominance, the book Orange World and the podcast Bubble.

Author of books, graphic novels and comics including DC's Batgirl Cecil Castellucci (@misscecil) joins Matt, Andy and her neuroscientist father Vincent to talk about her new graphic novel memoir Girl on Film, which intertwines the story of her life in the arts and schooling at Laguardia High School of the Performing Arts with sidebars on the neuroscience of memory and a look at Vincent's life's work in that field.

Comedian Louis Katz (@louiskatz) of the podcast Road Heads joins Andy and Matt to discuss robot deliveries, semen shocks (and overly detailed pictures), honking dinosaurs, the Jurassic Park melodica cover, plants making noises, Mort Garson's music for plants, Brazil's museum that burned down, browncardigan.com, a robot space hotel and who's in space right now.

Comedian and game show-hosting veteran Bil Dwyer (@BilDwyer) returns to the podcast 7 1/2 years after his last appearance to talk about Dirty Rotten Cheater, more reasons to hate paper straws, the greatest prank call ever, BLEVEs, frozen dogs, shrinking birds, tattooed mummies, audiophile coral reefs and a possible fifth force of nature.

Matthew D. LaPlante (@mdlaplante), author of the new book Superlative: The Biology of Extremes, joins Matt and Andy to talk about all creatures great and small (and fast and slow and strong and old and deadly...) and look at the many surprising things to be learned from nature's outliers.

Comedian/writer/podcaster Chris Mancini (@chrisjmancini) of Comedy Film Nerds joins Andy and Matt to talk about the good Kickstarter for his graphic novel Rise of the Kung Fu Dragon Master (and a less-good one for this dumb wine thing), what the deal with Pez is, toilet stickiness, Ohio religion laws, L’Hopital’s rule, supernova blobs, pigeon bones, antibiotics resistance and why you may not have to finish taking all of yours, pig organs, tonight's northern lights, Andy's Guilty Treasure show tomorrow, suspended animation and Michael Moschen’s Labyrinth juggling. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access to thousands of lectures by visiting TheGreatCoursesPlus.com/probably

Comedian Noah Gardenswartz (@noahgcomedy) of The Marvelous Mrs. Maisel joins Andy and Matt to discuss left-handed women’s smell, cannibal ants, cg mustaches, an ebola vaccine, anti-vax Facebook ads, mouse deer and Mars air. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free trial with unlimited access to thousands of lectures by visiting TheGreatCoursesPlus.com/probably

Comedian and host of the radio show/podcast You're the Expert Chris Duffy (@youretheexpert) joins Matt and Andy to talk about rats driving cars, why measles is bad, the book Antisocial, fake news in Argentina, beavers on the moon, eagles racking up roaming charges, a thermal camera that spotted cancer, Google's quantum supremacy and the guy who coined the term, brewing beer in your stomach and why breathalyzers aren't to be trusted.

Artificial intelligence researcher and UC Berkeley Professor of Computer Science Dr. Stuart Russell joins Andy to talk about his new book Human Compatible: Artificial Intelligence and the Problem of Control, which explores the concept of intelligence in humans and machines, what the benefits and drawbacks of creating superhuman intelligence are, and what AI researchers can do now to help usher in a future that's more utopian than dystopian.

Comedian-turned-writer Daniel Dominguez joins Matt and Andy to talk about his new animated Netflix series Seis Manos, Nobel Prize announcements in physics, medicine and chemistry, Ursula K. Le Guin, people with Goodenough names and implanting false memories in birds. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free month of unlimited access to thousands of lectures by visiting TheGreatCoursesPlus.com/probably

Comedian Troy Walker (@troywalkeresq) joins Matt and Andy to discuss erector sets, owl pellets, scientists growing tooth enamel, aspen sunscreen, a Milky Way explosion, Dr. Magma, too many wallabies, university ripoffs and antibiotic resistance. This episode is brought to you by The Great Courses Plus, offering Probably Science listeners a free month of unlimited access to thousands of lectures by visiting TheGreatCoursesPlus.com/probably

Comedian Matt Monroe (@heymonroe) joins Andy and Matt to discuss retirement community shows, Sandler on Netflix, the Salton Sea, the toilet water scale, Terence Howard science, lizard womb babies, lady rabbit orgasms, Sarah Morgan's web series, a tooth bird fossil, Matt Monro and Born Free.