Comedian Paul Jay of the podcast The Biggest Mistake (thebiggestmistake.net) sits in with the boys to talk about: Armchair astronomy! Getting Robert Plant to guest on the podcast! Pronouncing Led Zeppelin song titles! More horrible segues! How much would you pay to go to space with Tom Cruise? Sub-orbital streaking! Vibrating tattoos! Checking off items on Paul’s Probably Science bucket list! Growing new body parts! The search for Amelia Earhart! Venice is sinking! Brooks asks German kids the tough questions! Hydrogen-powered robotic jellyfish! The theory of circulation! Lobotomies! The Bridgetown Comedy Festival!

Chris Franjola (@ChrisFranjola) of Chelsea Lately, After Lately and Are You There, Chelsea? may not have studied much science, but he has some great takes on topics including: Being a theater nerd! Midwest tubing adventures! KISS-brand deodorant! Dave Grohl and the Heartbreakers! Catching a NASA spy Chris Hansen-style! Audition tips from Brooks! Figuring out why shock therapy works! Does Chris believe in depression? Our phone-obsessed culture! Comedy: Chris’s anti-drug! Have we found the cause of baldness? Tim McGraw and Dwight Yoakam: Two cowboy hats away from being Radio Shack managers! Brooks get a #1 Arthur Fonzarelli haircut for $6! Don’t judge a movie by seeing it on a plane! Why hasn’t the Segway conquered the world? Using lasers to see around corners! Laserdisc nostalgia! Brooks’s racist pet names! Hollywood Boulevard superheroes! Holding a gun makes you think everyone else is, too! Drunk Steven Adler buying Top Ramen! Sean Young crashes Andy’s comedy show! How did we discover mass extinction? Chris’s love of Theodore Rex! Wolfmother intros!

Auggie Smith (auggiesmith.com), winner of the Seattle and San Francisco International Comedy Competitions, sits down with the boys in Andy’s backyard to talk about: Auggie and Andy trying out for Jeopardy! Matt explains what “gunged” means! Guiding lightning with lasers! Matt’s Dickensian childhood! Babies are smarter than computers! Is Carl Weathers a poor man’s Clark Gable? Who’s your favorite painter? Did Bill Murray think “Garfield” was a Coen Brothers movies? Brooks and Andy’s juvenile “Into the Wild” fixations! What do you do when your island ends up underwater? Setting the 3-D nanoprinting speed record! Going to space: Bad for your eyes? Chuck Yeager: Bigger badass than Buzz Aldrin? Thumbs up or thumbs down on foreskins and motorcycles? Isaac Newton’s apocalyptic predictions! Has anyone turned down being knighted?

“Who Charted?” host Howard Kremer (@howardkremer) is our guest this week as we discuss: Jim Cameron’s adventures under the sea! Solar Flares acting up again! Old memories interfering with new ones! Cockfosters and Crouch End! Andy's Andrew WK/Iggy Pop/Bob Seger connection! The Cleveland Volcano in Alaska is acting up again (and that's not a sex joke)! Summah solidarity! Giant insects found on a patch of dirt on Skull Island! The Clap: Now drug-resistant! The history of anesthesia!

You’ve seen comedian Jesse Case (twitter.com/jessecase) on Last Comic Standing and this season of Parenthood. Oh, and he’s Andy’s roommate, and the creator of our theme music! Jesse joins Matt, Brooks and Andy to talk about: Breakups! Andy and Jesse’s strange living situation! Asteroids ending the world in 28 years! Plans for the apocalypse! Microchip fraud! Tutoring software that responds to emotion! The T. Rex: It bit even harder than we thought! Solving our energy crisis with poop! Eulogy for a surrogate sea otter! Andy the cat hitman! Magellan’s magical mystery tour!

Brody Stevens (brodystevens.com, @BrodyIsMeFriend) of both “Hangover” films, “Due Date” and general awesomeness, joins the gang to discuss: Favorite HBO Shows! Erotic thrillers! PG-13 boobs! The government’s “Avatar” ripoff! Prancertron-2000! Who’s worse at a party -- the guitar guy or the magic guy? Partying with Dane Cook and Jerry Cantrell! Listener feeback: Whales are delicious!, Resurrecting a 30,000-year-old plant! Vegan dogs! Tarzana: Actually named for Tarzan! Census-designated places! Russian gangster accents! ASU baseball! Brody’s 91 mph fastball! The world’s longest kidney chain! "Human Centipede": Not that good! The “Troll 2” dentist! A "Mythbusters" cannonball pulls a Family Circus through the 'burbs! Firing ranges with racist targets! Boozy fruit flies! Babies learn faster than we thought! Will the Hangover baby be traumatized? Poorly researched name-dropping! Calling out your friend’s "ALF" lies! The magic healing power of magnets! John Glenn’s historic space flight! Buzz Aldrin: Ultimate badass!

Chelsea Lately's April Richardson (aprilrichardson.com) sits in with the boys to talk about: Brooks making his own "Drive" lab gloves! Ryan Gosling & Tom Brady: attractive? Science proves that booze makes you smarter! Brooks got some eyeball pieces in his mouth! Should all scientists just work on cancer? April hates space, went to Space Camp! Robot camel jockeys! And that's not racist! Swiss space janitors! Which Batman is your generation's Batman? Salman Rushdie's Red Shoe Diaries! April: class clown or class heckler? Brooks gives everyone 100%! Don't judge flying 'til you've tried it! $23 million textbooks! Dueling mathematicians! Fermat's last theorem! Brooks had too much positive reinforcement!

Comedian Kyle Kinane (kylekinane.com) joins Matt, Brooks and Andy to discuss: Sexy snakes! C. Everett Koop dissecting cats! Pangaea 2: Tokyo Drift! Aliens and atheists! Human hypersleep! How the zebra got its stripes! War dolphins! Loose shakers! Deadly farting lakes!

21 Jump Street's Johnny Pemberton (www.johnnypemberton.com) talks with us about: Subliminal science projects! Fallback jobs! Using monkeys to measure radiation! Who would last in a zombie apocalypse? Shutting down Occupy LA! Chimp attacks! Brooks’ helper monkey! Warmest cold year on record? 2011: not so good for weather catastrophes! The Bill of Rights! Brooks and Johnny love guns! The God particle! Old Testament science! First humans to leave Africa! Mnemonic devices! 100th anniversary of reaching the South Pole! Johnny loves Antarctica!

Matt's back, and we discuss: Horror movie bird flu! Are the Japanese whaling addicts? Brooks' borderline racist accents! Russian scientists disappear searching for prehistoric lake! Own your own drone! How big is that ice chunk? Turing's gayness pardoned!

What killed all those New Zealand whales? Shooting nudist colony videos! What’s your worst job? World’s lightest substance! Extraterrestrial real estate! A vacuum is not nothing? Barry’s Conan suit! We're gonna be astronauts! Space Camp! Galileo!

Comedian Mike Burns of the podcast Gentleman Scumbags (http://www.pantswise.com/scumbags/) Joins us to discuss: iPhone anger! It’s official: no secret government aliens! Why is Mike scared of quinceañera aliens? Spontaneously obese monkeys! Bob Seger! Squeezing into Air Jordans! Mike got stabbed in the back! Literally! Naming new elements! Dr. Guillotine!