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DR RADHIKA VIJAY
Welcome all to "Is Pharmacology Difficult®️ podcast ". This is a Pharmacology podcast !! I am your host, Dr Radhika Vijay, M.B.B.S., M.D. Pharmacology, Sardar Patel Medical College, Bikaner, Rajasthan, India. Pharmacology (medical sciences) is my subject and I think Communicating about it to the masses is very essential. It is of great value and importance to every layman. The episodes here will be in simple English language (with few phrases and add ons of my favourite french language). The basic motto is to create an awareness and impart knowledge of the subject to all interested, concerned, curious and visitors. Pharmacology, the "SCIENCE OF DRUGS", which hold an important place in everyone's life. Here, I will discuss basic tips, strategies and ideas to study medical pharmacology easily and effectively especially for medical, nursing, dental and pharmacy schools and students. Even if you are not from Science stream, this information would be beneficial to you and therefore pay some valuable minutes to this Pharmacology Podcast, and you will not be in loss !! The descriptions will be short pieces of science work lengthy enough to engage you and not to test your patience! So, go ahead, lend your ears to these crispy informative audio files and empower and enrich your sea of knowledge and let me know "IS PHARMACOLOGY DIFFICULT?" For various links, please visit: https://linktr.ee/ispharmacologydifficult. Disclaimer: All the content of the podcast audio is expressed in my own language and learning and understanding viewpoints. References are from the best and reputed subject (Pharmacology) text books, blogs, journals and drug information from reputed and best online sources. I make best efforts to convey the most accurate and updated information of the subject of medical sciences in my special way. I take no money from pharmaceutical industry or drug companies for my podcast. You are most welcome to post your comments, suggestions, etc. through "Contact" page on my website: www.ispharmacologydifficult.com. You all are well known that medical sciences subjects are ever changing, updated and ever evolving, hence no guarantee is taken if the information conveyed in this podcast turns outdated or obsolete with changing and evolving times. This podcast is an expression of my learnings and experiences and in no way representative of any standard authority. Privacy Notice: I collect only email addresses of the subscribers and in no circumstances they will be shared or displayed anywhere on podcast/website/newsletter. Copyright & Distribution: All the contents of "IS PHARMACOLOGY DIFFICULT®️" podcast/website/blog/newsletter are copyrighted. Though all the content related to podcast and various social media handles is free! "BUT" in no way or under no circumstances shall- Any of the podcast content/show notes/blog post/newsletter content/youtube video artwork/podcast artwork and ideas should be used or reproduced or distributed.
Is Pharmacology Difficult Podcast PHARMACODYNAMICS-ENZYME INHIBITION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Firstly its my great pleasure to wish all a very "HAPPY TEACHER'S DAY". Its a great day and yes I am here with a great discussion topic i.e. Enzyme Inhibition. First of all I will define as a ritual, then with no delay I will discuss its two main types, namely Competitive and Non Competitive Enzyme Inhibition. I will discuss their main features or characteristics, the basic mechanism and yes never to miss, never to forget the wonderful examples!For your utter knowledge, i want to state that Competitive Enzyme inhibition is again of two different kinds, namely Equilibrium and Non equilibrium type and they have their own properties, you need to know them all!The status of Km and Vmax changes for all types and thats worth noticing and remembering, in the end with glory and hail to all preachers and teachers, I will be winding and ending for the great fun filled Sunday! Hope you had a real nice one! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
13:3105/09/2021
Is Pharmacology Difficult Podcast PHARMACODYNAMICS-DRUG MECHANISMS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be further stating the essence of Pharmacodynamics especially the introductory part!Initially I will be stating various drug mechanisms like Activation, Inhibition, Complexation and Neutralisation. All discussion is supported with examples, then I will tell most importantly that Drug mechanism can be receptor or non receptor mediated.Then I will start off with Elaborations about Enzymes, very detailed and specific conversations about Enzyme Stimulation and Enzyme Induction, their essence and differences.All this talk will be the meat and potatoes of today's verbal session.Withdrawing my words after enlisting important enzyme inducers, I promise to continue in next episode, not making too much of the talk just for the sake of few minutes, hoping a magnificent, spiritual Thursday for all!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links via - https://linktr.ee/ispharmacologydifficult
08:5926/08/2021
Is Pharmacology Difficult Podcast INTRODUCTION TO PHARMACODYNAMICS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be introducing Pharmacodyamics, definition, concept, and try to cover as one line statement, two line statement!!To begin with, today's little contemplation about Criticism, how big deal is it?, how important and wisely you can deal with it, is it really worth a panic? and much more!!And then as our topic proceeds, we will talk about the important drug actions like stimulation, depression, cytotoxicity, replacement, etc.And later I will cover important sites of drug action like Extracellular, Cellular and Intracellular!With these little but important concepts and knowledge bytes, I will be wrapping up with a great tip to be generous with praise and cautious with criticism, and pray and wow never to be trapped in either one!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
08:4413/08/2021
Is Pharmacology Difficult Podcast THERAPEUTIC DRUG MONITORING (TDM)
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. I welcome you all to make the podcast sound better cause its a Friday!!Singing the glory of being our best version throughout the week and a wish to start weekend afresh, I will introduce the topic of the day, its actually Therapeutic Drug Monitoring.As our custom, I will be defining it, tell you about its features, when it should be done, when its performance goes in vain and critical steps and conditions to monitor the time interval between drug administration and drawing sample for TDM!All this and much more wrapped up in today's episode rigmarole, Listen to unwind the unheard..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
10:4106/08/2021
Is Pharmacology Difficult Podcast DOSING SCHEDULES-2
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Marking the celebrated beginnings with essence of birthdays of dear ones, i will quickly follow the ritual of announcing the topic of the day that resounds like Dosing Schedules. In this head, i will talk about drugs having real long half lives, that is more than 24 hours. What are different guidelines, rules, regulations and criteria to administer such drugs especially when they have high volume of distribution. It would be great to discuss states like casual and emergency!And whether the person is considerably healthy or possess impaired renal and liver states , all these matter along with altered pharmacogenetic conditions!Lets spend some time dedicating to subjects essence while we hurry to join a much awaited celebration...... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
07:3627/07/2021
Is Pharmacology Difficult Podcast DOSING SCHEDULES-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's I will be covering details about Dosing schedules. I will be narrating definition, aims and objectives, different conditions and states as far as duration of half lives are concerned.You will notice how importantly duration of half life affects the route of drug administration, the frequency of dosing, the dosage form, the dosing schedule! Thats the essence of the topic, Later, I will be summarising important points with few more touch up information strokes, hope you all like it! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
13:5919/07/2021
Is Pharmacology Difficult Podcast PLASMA HALF LIFE OF DRUG-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be emphasizing on the value of Wait, Patience and waiting for worthwhile things in life! That actually makes a lot of sense!The heading of today's talk dancing in fonts is the "plasma half life of drug".To start with, its a good ritual to define the topic and then discuss the minute details, and so will I do. After definition, I will be focussing on deriving a formula for the same and very efficiently will accomplish it. You can actually calculate t1/2 of a drug by knowing parameters like Clearance and Volume of distribution. Next I will be talking about differences regarding first order and second order elimination kinetics. Then I will be covering topics like "Repeated drug administration", "Steady state plasma concentration" and "Plateau principle" in depth of conversation. To brush up, a few concepts will be listed, and then and there I will wrap it all for the day, making episodes lengthy is simply testing the comprehension capacity of mind which shouldn't be exhausted!With the idea of covering a couple of few more episodes in the same stream of topic, I will wave a bye! Have a chocolate on the "CHOCOLATE DAY" and stay sweet in conversation, thats too an art! Right? For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
10:2107/07/2021
Is Pharmacology Difficult Podcast ZERO ORDER ELIMINATION KINETICS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be emphasizing the essence and feel of returning home after long work hours or days out, its actually great and conveyed today in a quite melodious way!! Hope you all like it.Today's topic is Zero Order Elimination Kinetics. I will discuss the importance, examples and very nicely describe the mechanism and characteristics in bullet points. The effect on half life, clearance , all will be crystal clear. I will be justifying the different names given to this elimination kinetics like Mixed Order kinetics, Michaelis Menten Kinetics, Capacity Limited Elimination and Non Linear Elimination.All in in all The end statements will be dedicated to blood flow dependent elimination and reviving the strong feel while way back home in verses of Boyzone classical band, I will call it for the day!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:4428/06/2021
Is Pharmacology Difficult Podcast FIRST ORDER ELIMINATION KINETICS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today I will be emphasizing on the upper hand power of listening over hearing!Yes, both are so different, we actually rarely listen!! Today, I want you all to listen to me. What are the different features of First order kinetics of elimination and what is the essence of knowing it all? All these quests will be resolved in today's episode.No delays and i will break into the features straightaway of First Order Kinetics of Elimination with the examples , the concept gonna be crystal clear!You are expected to listen today nicely all the points or characteristics or features of First order kinetics of Elimination because most of the drugs are following it!I will be explaining thoroughly the relation to plasma half life, the dose concentration time curve, its plotting in logarithmic form and how it becomes so important. I will clearly in depth dive into the two slopes of drug clearance, the alpha and beta slopes and will tell you the difference in distribution and elimination half lives, their importance and relevance .Its gonna be a good package of knowledge and information for Tuesday! In no mood to commence the topic of plasma half life today, I will be setting the enunciation into recess till my next convo voice expected to reverb very soon!! With the expectations that you gonna make the most of your talents today, a thoughtful bbyee.. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:2522/06/2021
Is Pharmacology Difficult Podcast KINETICS OF DRUG ELIMINATION-DRUG CLEARANCE
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will be emphasizing the hand in hand coordination of knowledge and wisdom. To start with, I will tell you the essence of knowledge of Drug elimination kinetics. I will define the topics and areas it covers, what all and why do we need to know it thoroughly!!The beginnings will be stated by defining the subhead for the day and it sounds like 'Drug Clearance". I will first be defining it, then I will give the formula for it. Next, I will be telling you about important implications and noteworthy essence of different aspects, situations and conditions of clearance!What concerns and cautions govern the drug administration? How does the clearance refers to creatinine clearance? All will be made crystal clear. In a way, I will put your brains to exercise for computing the sumtotal value of clearance by knowledge of renal and hepatic clearance. With signature remarks about the values of renal clearance in relation to Glomerular filtration Rate and tubular secretion and before that a few comments about plasma half life, I will be calling it for the day, hope you find a certain meaningful value out of today's convo..,till we chat next, a soft bbyee.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:5117/06/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ELIMINATION-4
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I know the essence of French Open Tournament, wishing your favourite player the bestest of luck and wishes, if I am interrupting the score commentary, I do apologise, and promising a laconic set of colloque for the great Sunday, I break the ice with left over pizza pieces, i mean conversation about renal routes of drug elimination, in that too specifically , I will limit my talks to one process i.e. tubular secretion. I will discuss the mechanism, process, drug transporters, site, carriers, important facts, notable points, good gracious examples and everything you need to know about the process of Tubular Secretion.With the terse talk for Sunday, I advice you to carry on watching the score and keep the end excitement "ON" till you finally see the trophy in either Stefanos Tsitsipas' or Novak Djocovic's hand!Its truly a thrilling weekend! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
07:1513/06/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ELIMINATION-3
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.I will be starting today's episode with a beautiful thought compilation about "Lantern" and the book "Sky Lantern" by Matt Makeloto, its a lovely contemplation!Then i will cover the start of last route of Drug Elimination for our list and it is the Renal Excretion. Its the interplay and mathematics of three key processes namely Glomerular filtration, Tubular reabsorption and Tubular Secretion.For the bright today, I will be covering details, factors, mechanism, process, examples and all about Glomerular filtration and Tubular reabsorption. Rest of the episode's strings gonna reverb in next episode. Till then Chau..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:2910/06/2021
Is Pharmacology Difficult Podcast DRUG DOSAGES
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's bonus episode, i will be covering a true bonus value topic about Drug dosage, there are 5 types that I will talk about, namely 1. Fixed Dose 2. Variable dose (with crude adjustments) 3. Variable dose (with fine adjustments) 4. Maximum tolerated dose 5. Minimum tolerated Dose. Describing the essence of a bonus episode on Bonus Sunday, do l et me what it means for you? With a short lived bonus episode, I will be wrapping up today's truly bonus valuable convo, hope you felt the same way. Did you? For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:1705/06/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ELIMINATION-2
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will talk about the whole details, mechanics and essence of Elimination of drugs in breast milk. Why this knowledge is important? is the first question answered. Then I will discuss some physiological rules, mechanism of action governing it, all the processes involved and much more....Next I will give few examples, explain the much involved Ion trapping mechanism, etcI will be covering a list of Drugs involved in breast feeding, almost all groups or groups of drugs will be covered, it will be thoroughly explained upto what extent, mild, moderate or severe does the drug has side effects, whether its safe or unsafe!With all this bag off loaded information and data, I will punch the ending of the episode with my glimpses about road turns adorned with beautiful quotes by Hellen Keller, etcHope you all liked it! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!! You can access various links via.-- https://linktr.ee/ispharmacologydifficult
12:1305/06/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ELIMINATION-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Live your life by a compass not by a clock, with this mantra, I will break the ice for today's episode, always try to be a compass, not an anchor, not a ship! With a compass, you will realise that all those who wander are not lost!!Today's education compass points towards Various routes of Drug Elimination and while I continue the untold part further, today's first head of talk is Feacal elimination, I will discuss in detail and will tell you about the mechanism, examples all in all!Next head of discussion is about Pulmonary/Alveolar Elimination. Its ideal for Volatile liquid drugs, Gaseous drugs and I will be giving you some nice examples, a little mechanism and medico legal importance via breathalysis!Lastly a few of the not very important routes to cover are Sweat, Saliva, Skin and Hair etc. I will give examples for each of these, Lastly a little contemplation and jest about Compass to teach you all to laugh uproariously at your own jest Sometimes, Someday!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
08:0002/06/2021
Is Pharmacology Difficult Podcast DRUG ELIMINATION KINETICS INTRODUCTION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will answer your question , the one centred around topic of the day-"How drugs are eliminated?"Then I will tell you the difference in terms Excretion and Elimination. I will then start off the talk with discussions about Presystemic metabolism or First pass metabolism. After deriving an equation about Hepatic Extraction Ratio, I will officially start my talks about topic of the day i.e. Introduction to Kinetics of drug elimination. I will be listing various major and minor routes of drug elimination, then I will be initially give full description of Biliary excretion.In this I will be laying special emphasis upon "Enterohepatic Cycling". Definition, essence, examples, features, mechanism, exceptions , all will be conveyed and explained nicely! I will be concluding today's talks with two phrases or words of wisdom, science and mathematics to solve day to day dilemmas ! To wrap up, until next time(A' la prochaine!)..... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
10:4231/05/2021
Is Pharmacology Difficult Podcast FACTORS AFFECTING BIOTRANSFORMATION OF DRUGS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Let us be quite very truly, genuinely be thoughtful, in deepest mindset very thankful to lord for the blessings countable and easily experienced as cool showers amongst hot humid weathers!The trendy topic for a thankful Thursday is knowledge of factors affecting drug metabolism or drug biotransformation. The most important ones are age, genetic variations, diet, food, nutrition components , drug interactions and pathological states. While not much of great importance are the factors like sex, race, species etc. though I have given examples of animal models for these too, but primarily keep the above points in mind as they form the pillar factors causing sea changes in biotransformation or metabolism for lot many drugs! With this set of factors, we officially finish the discussions about drug metabolism or drug biotransformation and our jet plane heads while soaring high in sky towards the last pillar of pharmacokinetics i.e. Drug Elimination, Wow! the News is that from next episode we gonna begin Kinetics of Drug Elimination!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
15:0227/05/2021
Is Pharmacology Difficult Podcast ENZYME INDUCTION & ENZYME INHIBITION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will talk about definition, important details, clinical relevance and apt examples regarding both enzyme induction and enzyme inhibition. Though a little lengthy episode but no regrets for action, its only meant for inaction!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
16:4023/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-PHASES OF DRUG REACTIONS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, my advice to be expanded all throughout today's tell tales is "Follow the river and you will reach the sea". Yes to embrace the immensity, vastness of sea, you need to follow the particular mannerism and fashion of a task consistently in order to experience the completion and sufficiency.With this thread in our hand, lets start spinning up the introduction to our episode, it starts with Phase 1 reaction, which further branches in oxidation, reduction and hydrolysis reactions and then they have their own subtypes and yes examples too!!Next comes the Phase 2 reactions, in these I will narrate the essence of Conjugation, Acetylation and much many minor metabolic pathways and yes their subtypes and examples too!!All the reactions will be discussed in sufficient details and lastly I will be giving a signature talk about Hofmann reaction or better to understand non enzymatic reactions!!With these utmost important discussions, time strikes the moment to call it for the day and end the soaring fun ride in this sea, hope you all experiences the vastness of waters and dived in to achieve complacency!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
15:1720/05/2021
Is Pharmacology Difficult Podcast DRUG METABOLISING ENZYMES-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Wonder is the beginning of wisdom!! I'd rather open my mind with wonder than close it with belief!! That's the mantra for today as I start the topic of day which goes on like "Drug Metabolising Enzymes-1"I will start my convo by classifying metabolising enzymes into Microsomal and Non microsomal. Then I will throw light on each of the characteristics, features, sub heads and examples of each type, their details though not in much depth will be conversed upon!!i will in detail cover variety of isoenzymes of superfamily cytochrome P450, their different isoenzymes, features, inducers, inhibitors, etc.I will be talking in detail about nomenclature, specificity and genetic variability.That is the time and moment not to give in or give up, rather listen to clock's command to call it for the day and pack it all in! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
12:0718/05/2021
Is Pharmacology Difficult Podcast CHEMICAL REACTIONS OF BIOTRANSFORMATION OF DRUGS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.I will make you through a joyride of the zoo, the yester tears you explored fondantly the wildlife, the giraffe, the monkeys, the royal bengal tiger!!I know it was a trip or picnic or educational tour, if it were not a zoo, many species would have become extinct. Cleverly, I will shift your mindset to the topic of the day i.e. chemical reactions of biotransformation of drugs.The drugs primarily go through two main reactions or phases of chemistry, namely Phase 1 and Phase 2 reactions !I will discuss tits, bits, all in all complete characteristic profile of both the phases, not exactly compare them but yes you can build it once you know all. All examples, exceptions will be discussed, a complete profile coming up!As the topic approaches an end, I will be wishing you all a bunch of wishful weekend!Tis the moment, I will call it for the day! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
09:3215/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-DRUG METABOLISM / BIOTRANSFORMATION OF DRUGS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.A little floating in days of my painting lessons, I describe my still life painting as I post it today on my audiogram, this is how I begin today's convo, the colors of today's episode stand out to tell the topic of day, the drug metabolism or biotransformation of drugs!I will be defining it for you all, will tell its essence and features. Then I will throw some light on the variety, mainly three consequences of the process of Biotransformation of drugs like inactive drug, next active metabolite from active drug and lastly active metabolite from inactive drug! Along with details, I will be giving you the list of examples, very well known and apt list of examples will be conveyed to you all, with this set of information I will be calling it for the day ! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!You can access various links viahttps://linktr.ee/ispharmacologydifficult
07:3813/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-REDISTRIBUTION OF DRUGS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.I'm gonna sing a song by Maher Zain in the beginning of the episode as a true epitope of admiration for all the mothers, mine, yours, and everyone's. Then I will start my short and sensible talk about Redistribution of drugs!Well I will start with definition, the basic features, then explanation with examples of apt drugs will govern the discussion heads, that is how I will explain the whole topic, its essence and its various inferences and results. How the process occurs, what are its impacts and how it can be modified to make a drug long acting, all this will be a part of my weekend tale! Nothing bothering, nothing fancy, simply a three lettered word "BYE", Wishing good times for all this weekend!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
06:0309/05/2021
Is Pharmacology Difficult Podcast APPARENT VOLUME OF DISTRIBUTION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.A poetic standing ovation for all the blessed weavers worldwide, I begin today's colloque in way written by the great Sarojini Naidu, the Nightingale of India,I read this poem in my primary section and performed well so remember it really nice, the motto of the day will be to weave new sentences out of old tales, the topic sounds like the "Apparent volume of distribution" I will explain the definition, the concept, then i will be reflecting upon the formula, I will talk then about the inferences of knowing this concept of Volume Of Distribution.I will be covering the main scintillating bullet points , lastly i will tell you method to derive apparent volume of distribution i short and then will be talking of education aspect of spinning and weaving, That's all dear folks... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
15:1607/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-PLASMA PROTEIN BINDING
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be giving you all a riddle to answer, travelling through the classical days of mailbox, that would make remember Benjamin Franklin, cards and letters, hope you enjoy this visit and the beautiful poetic riddle! Today's mail for the day has its topic enclosed as Plasma Protein Binding, under this head I will discuss the acidic and basic drug binding proteins, their rules, strategies, fixed mechanism, importance and consequences.I will give you examples, important implications of plasma protein binding, what are its effect on drug states in body. How the drug concentration is affected, all this and much more is in today's MAILBOX!!!Hope you all like it, with a little pen and paper exercise, I will be knocking it off for the day! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
13:2304/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-VARIOUS DRUG RESERVOIRS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will be opening the verbal documentary about various drug reservoirs found in our body apart from plasma proteins! One thing you need to get real clear in your mind is that Drug Binding is not equal to drug action! Hope that gets real well understood!I will start my talk with tissue binding of drug, to nucleoproteins, etc. Then I will lay emphasis on the importance of sites/tissues/places like aqueous humor, peritoneal cavity, cerebrospinal fluid, etc.Fat/Adipose tissue serves as a very good site of collection of lipid soluble drugs, then what state of body affects this accumulation is all that matters! Then I will be telling you about drug dwelling in connective tissues like bone, nails, etc. Keratin precursor cells assimilating certain drugs will be a worth mention here! Sharing with you all my quick cappucino moments from Grasswood Cafe in city of lakes, India and with a promise to spill the leftover coffee in upcoming episodes, I will call it for the Majestic Monday, hope it becomes mannered and manageable for you all by all means! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
09:3303/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-DISTRIBUTION OF DRUGS-2
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, my head to head begins from an utter remembrance and admiration for the ruler of Grand slams, my favourite tennis player. Then I will bend the tides of talk by continuing yesterday's chat about barriers to drug distribution , my description will start by describing structural details of Blood-CSF and CSF-Brain barrier, the drugs that can or cannot pass through and then I will complete the words and details about Placental barrier. I will give my expert opinions along with examples of drug that pass and cause harm especially during first and last trimester. So accordingly go for these only when most needed, else avoid.With a teaser of y next prattle heads, I will be praying for safety of all. Welcome the weekend by chilling at home, grabbing your coffee cups and sipping away your lockdown worries!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
08:1501/05/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-DISTRIBUTION OF DRUGS-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today I will taking you all through the looney tunes home theatre to a new topic all in all namely the Distribution of Drugs. Describing initially the definition , finally I will discuss the first barrier to drug distribution namely the Blood Brain Barrier (BBB) .I will make you all remember and revise a little anatomical details that will help you understand the mechanism nicely.Keeping my confabulations short and crisp to balance the last two lengthy ones, my purpose is to master the minutes about thing that really matter!Chau for now!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
08:1430/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-FACTORS AFFECTING BIOAVAILABILITY
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Taking you all through a long drive experience amongst the open skies, dawn time and mountain view, I would be inquiring within your choice of cars small or big and would be sharing my thoughts as to car defines not your personality but much of your budget defines the size of car. Well the car talk is just to let you all know, I got my car today, to drive my own ways!! Thats really enthralling.Finally we will find our terminus to perch and strike a meaningful convo for the day!Todays topic comprises of measures to determine the bioavailability, its formula, and finally a reflection on variety of pharmaceutical, biological and pharmacological factors that affect bioavailability. All these factors will be discussed in much detail with suitable examples. I will end this rollercoaster ride without wheels in a way to declare one more fact for the day that topic of bioavailability hails its finish today, and lot of new conversations await to outflow as waterfalls from my chords. No haste cos' its worth the wait!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
17:1929/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-BIOAVAILABILITY OF DRUGS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.With remembering and refreshing thoughts of the best days, the school days, specially beginnings of new class sessions, I will break the ice of today's episode in words of Dano Perino, this will arise the spirit of quest and query for the day's head of discussion, which is Bioavailability of Drugs!defining the term, Bioavailability, i will give a sneek peak into the historical origin of drug, then I will tell the measuring ways of it. Next I will reflect on the term Equivalence and tell the differences . Next, I will be talking about different types of equivalences starting with Bioequivalence, then chemical equivalence, then pharmaceutical equivalence, then pharmacokinetic equivalence, then therapeutic equivalence, and finally clinical equivalence!All these details and examples will be covered in a row, then with a perfectly rhymed phrase, i will set the fanatic folklore of the day to fade to finish! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
13:3127/04/2021
Is Pharmacology Difficult Podcast PSYCHOPHARMACOLOGY OF DEPRESSION IN CHILDREN (50TH EPISODE SPECIAL)
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today is celebrated day to go for the 50th episode special of my podcast! To make it really special, I have taken a break from ongoing series and got a bonus episode for all of you discussing all the insights, the tots-bits of childrens depression psychopharmacology. yes its a really common problem in so many homes, lands and regions and needs a real talk today, so why hesitate? Let's talk about it today and open the associated secrets with it.Every child is important, every child needs attention, respect, proper therapy, love and space in society to grow and nurture healthily without stress, disparity, abuse and rejection! Love and care for the child and see the future society shining as bright as sun!! Every child is a wet cement, whatever falls on them, leaves an impression! Their mental health is the society's mentality, pay heed to it and see a healthy social outlook developing by its own! Pandemic has taught so much, take another lesson at these tough times to care for your beloved children, they deserve the best of everything!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
25:1124/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-ABSORPTION VIA PARENTERAL ROUTES-2
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Hey!Hey!Hey! here comes the Friday, the weekend start and I have a real good news for you all that soon my half century will be hit and I will bring for you al La Fete episode which gonna be tres speciale! Today I will adding one more ring in the chain of Pharmacokinetics rigamarole, the discussion to form the preface of another day's chapter that unfolds something like this, the debut talks are about Inhalation route, in this drug can be as a gas, as an aerosol or as powder then I will tell the pros and cons of this route, next set of colloque is about Topical route of drug administration, in this I will separate the local and systemic desired effects. Accordingly I will be giving examples and add my end notes about plus and minus points of each type. In the end, I have a rapid fire round in two sets, first about factors enhancing drug absorption, second set of factors delaying drug absorption!With a cheerful warm welcome of the weekend, I will give you my made weekend rules if you really follow gonna bring spring at your end :)) For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
12:3823/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-ABSORPTION VIA PARENTERAL ROUTES-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today I will take you to the virtual pool of wishes coming true as you splash the coins facing your back towards it!The hour demands to wish harmony peace and health for all, wiping away this coin game scene, I will be introducing today's topic, absorption via parenteral routes of drug, in this today I will be talking about sub cutaneous, intra muscular and finally intra venous route, after discussing the complete absorption mechanism, I will discuss the pros and cons of each of the routes, these are so important as to form the basis of understanding the choice of the apt route in any given medical or clinical circumstances or situation.Before I depart, one question and advice for all of you, how many coins do you have in your pocket left with a hope to wish luck for yourself, the advice is never run short of these coins, cos these will be to wish for happiness, peace , harmony and good of all!! A little word about Apple event last night and amazing changes for us......... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
09:5021/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-ABSORPTION VIA ENTERAL ROUTES
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode I will talk about the relevance of administering drug via enteral route in regard to drug absorption. I will be discussing all the pros and cons of drug absorption as the drug is administered via different enteral routes like from mouth, into intestine, both small and large intestine, from sublingual, rectal routes. The whole talk will be in much detail with apt examples and yes! a word about first pass effect and pictorial framework of enterohepatic circulation will also be discussed in good details!I bet I won't tornadify your terrific tuesdays with my conversation rather will wow to end up this day with tasty tangy tacos!! :) :) For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
14:3720/04/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS-ABSORPTION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Its Sunday Matinee time and I am not the audience, but the host, As I steal a few moments from your precious day's time, I engrave and inscribe your lockdown diaries and learning via the chisel of my tongue.In today's episode I will be talking about "A" of the "ADME" study, it stands for absorption!I will broadly cover the little introductory part and then the basic determinants of absorption like area of absorption, vascularity, concentration gradient, routes of drug administration , etc and yes a little detail of each one. Few tricky things will be laid emphasis on and they will be made to learn by rote by you! Isn't that wonderful. With the idea of keeping my talks short and light for the weekend, as the clock hits wind'o clock, I will leave you with a tune riddle to solve of my recent favorite melody, just guess the renowned artist, Na...Na....Na....Na.......Na...... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
10:0818/04/2021
Is Pharmacology Difficult Podcast VESICULAR TRANSPORT AND FILTRATION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, a little brushing before I take a deep dive in true and exact process of Pharmacokinetics, let the oven preheat before true baking starts!!The heads covered are Vesicular transport and Filtration. As I solve the puzzle of tangled and knotty wool yarn of the day's talk, the beginnings of conversation are marked by definitions and explanations of Pinocytosis and Phagocytosis, two types of Endocytosis. Its own description is as simple as simplicity.After covering details along with examples for this heads mentioned, i will shift the tides of my talk towards Exocytosis, another good simple talk unfolds in words and this is followed by something too simple equalling to 2+2 addition in mathematics, which never turns greater as 5 , or less as 3, but exactly as equal to 4. Decorated with classical antique examples, I will pull down the curtains for today's talk while slowly curbing the pace and volume of my verbal proceedings, a quick tip to revise and learn better!Just grab it hard, and make a difference in your performance, nothing left untold.......... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
13:1916/04/2021
Is Pharmacology Difficult Podcast ONE YEAR BIRTHDAY ANNIVERSARY CELEBRATION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today's is a special one year birthday anniversary celebration episode for my podcast. I will be conveying my thanks, gratitude and happiness and giving all the great listeners a BIG SHOUTOUT!!!!!My only humble request and wish is to all of you great listeners is to stay tuned, acknowledge and appreciate my work, I will strive for better performance, best to my capacity and knowledge forever and always!!!!A BIG THANKS TO MY ESTEEMED LISTENERS, THANK YOU!!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
09:0514/04/2021
Is Pharmacology Difficult Podcast SECONDARY ACTIVE CARRIER TRANSPORT
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today's episode will be started with the current season update, the special season of Spring!The ball is set to rolling with the description of Secondary active transport, its features, its types, etc. The two types are based on the direction of movement of ions or solutes. If its same or opposite defines the two types. Next I will give examples of secondary active transporters. Then I will be describing in detail about Membrane transporters, the two superfamilies of transporters, ABC and SLC transporters. With these remarkable description, I wish you all "BELLISSMIA GIORNATA" , an italian phrase for a beautiful day!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
12:0712/04/2021
Is Pharmacology Difficult Podcast PRIMARY ACTIVE CARRIER TRANSPORT
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.As the clock hits the time of Pharm'o clock, I am here to talk about at brand new topic. Actually I will break the ice with characteristics of Up Hill Transport i.e. Active transport. I will be explaining all the terms in details with apt examples. Then I will shift this talk head towards the branches of Active Transport i.e. first and foremost "Primary Active Transport". In this I will be explaining the mechanism, the associated features, terms, etc. and finally as the time demands fading shades of my discussion sounds, I will be giving examples, all these wrapped up as bullet points. Then in a second I will be giving my thoughts of not spilling the carrier transport pudding leftovers further, rather will be saving these for our next virtual meet up. With a great shiny hope of seeing ya'all again very soon to sit and chat be the sides of the virtual round table decorated with books, cakes and coffee, it will be the final word of day to wind all , Bbyee!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
11:4709/04/2021
Is Pharmacology Difficult Podcast CARRIER TRANSPORT-FACILITATED DIFFUSION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today is the weekend special topic, its all about different variants of specialised transport mechanisms. Broadly they may be of two types, the carrier mediated transport and vesicular transport. First and foremost , as I talk about carrier mediated transport, under this head, today we gonna chat regarding Facilitated Diffusion. It has special characters which I will highlight and eventually summarize after a warm French welcome, just short enough to jingle your earbuds. Discussing the mechanism, pros and cons, examples and all tits bits of this type of diffusion, even a graphical representation will be told, all in all completely describing the facilitated diffusion, I will be keeping my conversation comparatively short for the day, wishing you all a great blessed weekend, in French too, and will be vocally departing till we talk back in next episode!!For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
06:5804/04/2021
Is Pharmacology Difficult Podcast HENDERSON HASSELBALCH EQUATION AND ITS IMPLICATIONS
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode, I will first make you all do rollercoaster revision ride about what all we have done in recent past episodes, too quickly and then we will talk about influence of pH on passive diffusion.Then I will give you all the equations separate for weak acid and weak base, I will highlight the differences in these too! Next I will derive few basic facts and concepts related to it, after describing a little, I will open up the bundle of Implications of this equation in a point wise manner. It gonna be a little long discussion, around 10 points but truly a worthwhile pleasure to listen to, That gonna be enough tea to flood your minds cups for the day, with a promise to meet again virtually and vocally after a small time lapse, that's all folks for today!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
15:1428/03/2021
Is Pharmacology Difficult Podcast PHARMACOKINETICS INTRODUCTION
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.In today's episode i will be commencing my talks upon Pharmacokinetics, the dreaded one!! But no worries, we will inaugarate the conversation in too simple way just good enough to settle in your minds highly simplified everything! First comes the definition, then basic concepts, ideas, rules of the theory of pharmacokinetics. It is famous as the ADME study, I will be giving little details about it then before actually diving deep in this sea, we will have a short walk along the shores as we discuss the audio diagrammatic representation of the whole pharmacokinetic process in nutshell! Then a word about the Biological membranes, their unique, specific structure and much more. I will be telling you important process about drug transport and how the diffusion concepts are related to membrane structure, all this comes into play in today's episode! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
08:5320/03/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-7
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today is a Golden day of marking end to this ongoing topic of routes of drug administration with initial few words of leftover routes like conjunctival, vaginal, inunction, urethral etc and finally with fair amount of discussions I will be summarizing all the routes in a rollercoaster ride as a rapid fire round under major heads of name of route, absorption pattern, advantages, disadvantages and wonderful examples, this whole lot of description would make it up more than long time for the day. Then I will be calling it for the day!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
21:1209/03/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-6
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Today's episode covers Transdermal Therapeutic System (TTS) in details with a few words about Nasal and Inhalational routes of drug administration and specially I laid emphasis on differences of the two.In all these routes as per the tradition, I discussed the important characteristics, features, details covering the mechanism, method, everything followed by pros and cons, essence, ignorance, and finally the last few golden moments comprise of examples for each route of drug administration.This tradition is very descriptive and interesting as it maintains my flow and focus of interest and as I end my speech for the day, just wanna say that little deeds make up more than one single great deed planned!! That draws the curtain down for the day.. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
10:1203/03/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-5
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also.After a little break, I am back with more information on injections, today the focus will be on sub cutaneous route of drug administration, I will be narrating important features, advantages, disadvantages and I will discuss different dosage forms for this route like dermojet, implants, etc. Next in my list I will cover Intraperitoneal, Intrathecal, Intracardiac, and in the same line their separate features, advantages and disadvantages and not to be forgotten, examples are always must, they complement all the discussions with full flash bundle of information, something just that cannot be missed, forgotten or left untalked. This description marks the essence of examples, hope you understand the depth of all these, I am sure you do!! You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
14:1426/02/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-4
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.After a long gap today's episode is a on going series of our topic injections.to begin with i will start today's talk with Intramuscular Injections where i will be discussing about the site , characters , features, advantages, disadvantages and examples for this route. And next in list is Intradermal Injections. with a few guess games to keep up the spirit, i will call it for the day. Hope you all liked it and had a great, lovely Weekends For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
08:3014/02/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-3
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.The celebrated topic of today's episode is the Parenteral Routes of Drug Administration, in this firstly I will define this route, its basic implications. My first choice of injections will be Intra venous, I will talk about its uniqueness, speciality and after explaining its need, etc, I will make you count firstly the advantages of this wonderful route of drug administration actually on your fingertips. The best aspect is 100% bioavailability. And then there are many more to count which will be delivered to the best of my knowledge in today's episode. And then the time will tick on and on and before it gets run out, I will be telling you the negatives of this route too, which are actually very important to know, because its one of the most risky route too, it has hazards associated, its side effects, their few of the solutions and these all will be spinned up tightly for y'all in today's woolyarn, so stay tuned is the golden advice of the day!! For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
11:1005/02/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-2
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.What are the basic good things to know about buccal and rectal routes, what are the pros and cons, all these scintillating points will form head points to form discussion content for today !!As we climb the ladder step by step by routes of drug administration, after oral, next step is sublingual or buccal. Then I will tell you minute difference between the two terms, though they are used interchangeably. Then I will abide by the ritual of counting rainbow colors as I highlight the advantages of this route, then disadvantages and finally the solid shining examples for this route of drug administration.Next my final words for the day will be about Rectal route of drug administration. In this head, I will cover need of this route, its special features, its advantages, then its disadvantages, and finally as usual examples for this route of drug administration.Today before I waive a final bye for today's episode, I will be sharing a blooper for you all, as my kid tried copying my podcasting skills and style, how much he succeeded in cute, imperfect, childish way , its worth listening as it will be so hilarious and make you giggle for a while. For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
10:3630/01/2021
Is Pharmacology Difficult Podcast ROUTES OF DRUG ADMINISTRATION-1
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.Why different drugs have different routes of administration? What are the advantages and disadvantages of oral route of drug administration? All these questions will be answered in today's episode. Firstly I will break the ice of today's episode with the different properties of drugs and different factors that govern the choosing of different routes of drug administration. I will be actually enlisting these. Then I will tell you the major routes of drug administration. Finally defining the enteral routes, their definition, exact site, I will begin my set of discussions about Oral route of drug administration. In these I will tell you which dosage forms can be given by this route, specifically which solid ones, which liquid ones, then I will be telling you some real good advantages and benefits of oral route and all these talks will be complemented with apt examples. As nothing is perfect, you all know, so is oral route, Last word i will discuss the imperfections of this route and I will tell why its not always the best choice for few special individuals and special circumstances. Without stretching the talks much beyond the comprehensive capacity of your minds, better to stop before it blasts! This statement marks the final destination of today's interesting conversation. Truly, no more comments for the day.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
12:4228/01/2021
Is Pharmacology Difficult Podcast MONOCLONAL ANTIBODIES AS DRUG DELIVERY SYSTEM
Welcome all to IS PHARMACOLOGY DIFFICULT Podcast! I am Dr Radhika Vijay.How do monoclonal antibodies behave as drug carriers? How are they named so uniquely? In today's episode I will be discussing all this mechanics. Monoclonal antibodies are an important drug delivery system, how the are structured in a very special unique way will be discussed first, then I will be throwing light on different epitopes, the Hybridoma technique to structure these products. It will tell you how murine and human parts and gene materials are fused and manipulated to make these desired antibodies. There is a role of genetic DNA technology and grafting techniques etc.After explaining little complicated structural details, I will jump to the naming technique of Monoclonal antibodies. There is a "mab" in the end part in name of any monoclonal antibody, just before "mab", letter is prefixed to tell the source of antibody, and before this letter, a letter or set of letters is placed to tell the therapeutic use. of antibody. All these will be complemented with suitable examples so that there is no space of confusion, doubts and queries in your mindset, got it. Finally, with my views on essence of good conversations, good sleep and the quality of being interested in right and valuable thins in life, I will be putting a fullstop to my talks for the day, hope you all like it and derive the maximum benefit out of this day's chat.... For all the updates and latest episodes of my podcast, please visit www.ispharmacologydifficult.com where you can also sign up for a free monthly newsletter of mine. It actually contains lot of updates about the medical sciences, drug information and my podcast updates also. You can follow me on different social media handles like twitter, insta, facebook and linkedin. They all are with same name "IS PHARMACOLOGY DIFFICULT". If you are listening for the first time, do follow me here, whatever platform you are consuming this episode, stay tuned, do rate and review on ITunes, Apple podcasts, stay safe, stay happy, stay enlightened, Thank you!!
14:2026/01/2021