In which Rob and actor/comedian Zach Galifianakis discuss North Carolina sports rivalries, when teleprompters are legal, pitching Baskets, Zach’s two weeks on SNL, the changing tastes in comedy, interviewing President Obama, and Zach’s brand new snowboarding movie from 20 years ago. Plus: Rob answers a question about his hometown in the LoweDown Line. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In which Rob and actress/comedian Vanessa Bayer discuss the pace of big cities vs the suburbs, Vanessa’s summer on Sesame Street, doing Rachel Green for Jennifer Aniston, the brilliance of Encino Man, and rank their favorite QVC hosts. Plus: Rob answers an unusual sports question in the LoweDown Line. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

Our GRAMMYs special, in which Rob and music production legend Clive Davis discuss the formula for a hit record, signing The Notorious B.I.G., passing on John Mellencamp, a new biopic about Whitney Houston, and the painting of Earth Wind & Fire hanging in the National Portrait Gallery. Plus: Rob and Clive weigh in on the greatest American songwriter.

In which Rob and actor/podcaster Dax Shepard discuss pre-interviews, the script for Idiocracy, Punk’d, Burt Reynolds' wetsuit, whether or not Rob’s dad taught Bradley Cooper his backhand, and much more. Plus: Rob answers a call about The Lowe Files in the LoweDown Line. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In which Rob and broadcaster/basketball legend Charles Barkley discuss The Dream Team, learning to say no, being grateful, taking responsibility, and the best advice that Charles never listened to. Plus: Rob answers a call about his favorite books in the LoweDown Line. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In which Rob and comedian/actor/podcaster Bill Burr dive deep on the NBA, the Royal Albert Hall, and compare notes on sobriety, cigars, and Star Wars. Plus: Rob answers the very first call to our new LoweDown Line. Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In which Rob and actor/author Matthew McConaughey discuss Matthew’s new memoir Greenlights, making Contact together, auditioning for Titanic, launchpad lines, Magic Mike, Wolf Of Wall Street, Joel Schumacher, and we finally find out who coined the term “McConaissance." Plus: Stay tuned to the end for the announcement of our new LoweDown Line! Got a question for Rob? Call our voicemail at (323) 570-4551. Your question could get featured on the show!

In which Rob and comedian/podcaster Joe Rogan talk about sensory deprivation tanks, working with the late, great Phil Hartman, the art of happiness, sugar addiction, and National Carnivore Month. Plus: Joe tells Rob exactly how to get “Marvel jacked."

In which Rob and actress/comedian/author Chelsea Handler discuss dating in a pandemic, learning to look busy doing nothing, and whether or not they share the same shaman. Plus: plans are hatched for Chelsea and Rob’s new celebrity ski tournament. Chelsea’s first standup special in six years, EVOLUTION, is on HBO Max now.

In which Rob and actor/comedian Kevin Nealon talk about impressions, meeting presidents, the people they’ve been starstruck by, drawing caricatures, and Weekend Update. Plus: we find out what Kevin finds interesting about the space between Rob’s nose and his top lip.

In which Rob and actor/comedian George Lopez talk about breaking out in the closing days of Johnny Carson, life lessons George took from his baseball coach, timing, luck, fear, and getting back up again. Plus: we hear the story of how George ended up as a witness at the Michael Jackson trial.

In which Rob and actress/comedian/writer Lisa Kudrow discuss the Friends reunion, parenting, Rob’s experience on Who Do You Think You Are, improv training vs dramatic acting classes, and much more. Plus: Lisa really wants to know what happened to The Grinder.

In which Rob and actress/comedian/author Jenny Slate discuss ASMR, meeting on the set of Parks & Recreation, Jenny’s SNL audition, and being allergic to cynicism. Plus: we hear about Seinfeld dropping in during an inopportune Weekend Update rehearsal.

In which Rob and producer/author/executive Peter Guber take a tour through Peter’s illustrious career, discussing films like Rain Man, Midnight Express, An American Werewolf In London, A River Runs Through It, and the power of narrative. Plus: Peter explains how crucial casting the right villain is.

Revisit our first episode, in which Rob and actor/producer Chris Pratt discuss formative favorites, their time together on Parks & Recreation, and Rob’s disastrous audition for Footloose. Plus: Rob and Chris discover they both have a surprising connection to Barbra Streisand.

In which Rob and writer/producer Mike Schur discuss quarantine cuts, virtual writers’ rooms, the vital importance of silliness, the SNL sketches that never were, and of course Parks & Recreation. Plus: we learn Mike’s response when told Chris Pratt had been offered the “racoon movie.”

In which Rob presents his Greatest Hits from the first year of Literally! with Rob Lowe, including appearances by Conan O’Brien, Gwyneth Paltrow, Mike Myers, David Spade, Demi Moore, Alec Baldwin, Keegan Michael-Key, Tiffany Haddish and many more.

In which Rob and actor/producer/author Michael J. Fox discuss the balance of realism and optimism, Transcendental Meditation, being in a jungle for six months with Sean Penn, and dissect some of Paul Simon’s most cryptic lyrics. Plus: we learn Michael’s favorite theme song from one of his movies.

In which Rob and actress/comedian/writer Catherine O’Hara discuss bad auditions, following in Gilda Radner’s footsteps, Schitt’s Creek's historic Emmy wins, and the secret inspiration for Moira’s look. Plus: Catherine challenges Rob to an on-the-spot impression.

In which Rob and actor/comedian/musician Jim Belushi discuss making About Last Night, the advice John Belushi gave to a 12-year old Rob, the birth of the Blues Brothers, and creating a sitcom marriage where nobody has to apologize. Plus: a $20 bet is on the line.

In which Rob and comedian Jo Koy discuss Las Vegas during the pandemic, pre-show rituals, keeping up with the Black Eyed Peas, and take a deep dive on Seattle sports and the Philippines. Plus: an announcement about Jo and Rob’s new street racing show, coming soon.

In which Rob and actor/comedian Eric Andre discuss beatniks vs hipsters, mean pranks vs funny pranks, and making the Eric Andre Show pilot in an abandoned bodega. Plus: Eric shows us his upright bass.

In which Rob and producer Jerry Bruckheimer do a deep dive on Jerry’s illustrious career in film & television, including the initial inspiration for Top Gun, casting Flashdance, the creation of the CSI franchise, dialing in Captain Jack Sparrow, and much more. Plus: we get the inside scoop on the forthcoming Top Gun: Maverick.

In which Rob and actor/comedian Jon Lovitz discuss the history of Jon's Saturday Night Live characters, the strange fate of his cat Mr Marc Stevenson, and roasting Arnold Schwarzenegger. Plus: we learn about the surprising original cast for Bad Boys.

In which Rob and journalist/author Maria Shriver take a deep dive on compassion, work ethic, family, succeeding in a boys’ club environment, and the positive aspects of solitude. Plus: we learn about a surprising letter from Rose Kennedy.

In which Rob and actress/author/comedian Jane Lynch discuss non-traditional pet names, Transcendental Meditation, working with Christopher Guest, and discover they have much more in common than they expected. Plus: we learn if Jane would rather see a UFO, a ghost, or a Bigfoot in another edition of The Lowe Down.

In which Rob and writer/director Aaron Sorkin discuss The West Wing reunion special, their favorite episodes of the show, how Rob was cast as Sam Seaborn, a disastrous moment from the opening night of A Few Good Men in London, and doing Chekov with Christopher Walken. Plus: Parks & Recreation superfan Aaron turns the tables and interviews Rob.

In which Rob and actress/comedian/author Tiffany Haddish discuss buying a theater together in Dayton, OH, roller skating in the '80s, and Rob gives his advice for upstaging Nicolas Cage. Plus: we learn how alike Tiffany and Sharon Stone really are.

In which Rob and actor/comedian Martin Short discuss making jokes at their manager’s funeral, who got cut out of Three Amigos, dealing with hecklers, SCTV vs SNL, and the meanest thing Jiminy Glick ever said. Plus: Rob tries to get invited onto David Geffen’s boat.

In which Rob and broadcaster/Pro Football Hall of Famer Michael Strahan discuss getting older, Michael Jordan vs Kobe, drawing strength from adversity, and the $100,000 Pyramid. Plus: Michael insists Rob explain what being "a fan of the league” actually means. Michael’s new clothing line MSX by Michael Strahan for NFL is out now on MSXbyMichaelStrahan.com

In which Rob and actor/writer/producer Alec Baldwin discuss tension on the set of Glengarry Glen Ross, a voicemail from George C Scott, the projects that got away, and their political ambitions (or lack thereof). Plus: we learn what was always on page 73.

In which Rob and comedian/actress/podcaster Nikki Glaser discuss her performance at Rob’s Comedy Central Roast, filling in for Paula Abdul, getting sober, and moving back in with your parents. Plus: we learn about Rob’s “Ikea Complex."

In which Rob and television personality/retired Olympic athlete Caitlyn Jenner discuss the history of her many iconic photos, her lifelong journey to live authentically, competitiveness, fame and family. Plus: we learn the surprising origin of Caitlyn’s name.

There’s a new show on the block, and Rob’s here to tell you all about it! Hosted by the hilarious comedian Rory Scovel, “Dads: The Podcast” is all about fatherhood, parenting, and the myriad ways our families have made us who we are—for better and worse. Here’s a peek at the first episode featuring a conversation with America’s favorite redhead, Conan O’Brien. If you like what you hear, head on over to Dads: The Podcast and hit subscribe!

In which Rob and actor/writer/woodworker Nick Offerman discuss their Midwestern roots, Nick’s time coming up on the Chicago stage, the specificity of character names on Parks & Recreation, and the importance of being present. Plus: we learn what it took to achieve Ron Swanson’s iconic hairdo.

In which Rob and actor/comedian Dana Carvey discuss poltergeists in Montecito, Mickey Rooney's lost projects, and sleeping in the Lincoln Bedroom. Plus: Paul McCartney provides a recap of the episode.

In which Rob and actress/producer/author Demi Moore discuss recording foley sounds for her new podcast Dirty Diana, shooting the courtroom scene from A Few Good Men, and reminisce about the effect director Joel Schumacher had on their lives. Plus: Rob tells the story of the infamous “Snow White disaster."

In which Rob and actor/comedian David Spade discuss SNL nerves, lost watches, and the infamous Spade/Farley fight on the set of Tommy Boy. Plus: we learn about the unusual outcome of a childhood game.

In which Rob and comedian/actor/writer Mike Myers discuss painting Colonel Sanders, shushing Paul McCartney, "who do you think you are" vs "who do you want to be," and the perils of getting another take from Quentin Tarantino. Plus: we learn the only two people in existence who actually have the hook-up.

In which Rob and actress/author/businesswoman Gwyneth Paltrow discuss their 30 year friendship, having Steven Spielberg direct your wedding video, and how Gwyneth has never really left Rob’s guest room. Plus: we learn the tenuous truism that gave Goop its name.

In which Rob and actor/writer/producer Keegan-Michael Key discuss eccentric NFL names, the vocal mannerisms of Danny Glover, Keegan’s role opposite Meryl Streep in the new Ryan Murphy movie Prom and so much more. Keegan's new show Game On! airs on CBS.

In which Rob and comedian/producer/talk show host Conan O’Brien discuss the difference between sharks and dolphins, how Elizabeth Taylor was able to cry on command, and why Conan thinks ghosts are overrated. Plus: we learn if Conan is actually Rob’s boss or not.