ALS is a fatal neurological disease that kills motor neurons. Even though it was first described more than 150 years ago, there is no cure, and the few drugs available only dampen the symptoms or slow the progression by a few months. In recent years new drugs have emerged. However, there is one problem: the life expectancy is just two to five years after diagnosis. This timeline is incompatible with the FDA drug approval process, which takes years and even decades. This has created a tense situation for desperate patients who are demanding the FDA approve unproven drugs. What’s the harm in giving desperate patients an imperfect drug? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions

In 1973 a bombshell study appeared in the premier scientific journal Science. It was called “On Being Sane in Insane Places.” Its author, a Stanford psychology professor named David Rosenhan, claimed that by faking their way into psychiatric hospitals, he and eight other pseudo-patients had proven that psychiatrists were unable to diagnose mental illness accurately. Psychiatrists panicked, and, as a result, re-wrote what’s known as “psychiatry’s bible”—the Diagnostic and Statistical Manual of Mental Disorders, or DSM. The study and the subsequent overhaul of the DSM changed the field forever. So it was a surprise when, decades later, a journalist reopened Rosenhan’s files and discovered that the study was full of inconsistencies and even blatant fraud. So should we throw out everything it revealed? Or can something based on a lie still contain any truths? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

For more than 100 years, biologists who suggested that some cancers may be caused by viruses were the pariahs of genetics. However, they persevered and incrementally built their knowledge, leading to the discovery of retroviruses, the development of a test to diagnose HIV, and the creation of the HPV vaccine. Join us as we interview Gregory J. Morgan about his book Cancer Virus Hunters: A History of Tumor Virology. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

In 1973 biochemist Bruce Ames created a simple test that showed if chemicals had the potential to cause cancer. The Ames test made him a hero of the emerging environmental movement. But then he completely changed course and said concerns about chemicals were overblown. So what happened? Did Ames change? Or did our understanding of what causes cancer change? Featured Oral History Bruce N. Ames, "Bruce N. Ames: The Marriage of Biochemistry and Genetics at Caltech, the NIH, UC Berkeley, and CHORI, 1954–2018" conducted by Paul Burnett in 2019 and 2020, Oral History Center, The Bancroft Library, University of California, Berkeley, 2021. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

Ozempic and others in this family of drugs are nothing short of miraculous. Meant to treat Type 2 Diabetes, the drug exploded in popularity after researchers found that patients were reporting losing 15-21% of their body weight in clinical trials. There were some side effects, but none so severe that it raised concerns. Doctors began prescribing it to people who weren't diabetic but could benefit from weight loss, and now, our only problem seems to be getting enough of it for all the people who need it. It all seems magical, but is it too good to be true? Join us as we dive into the history of weight loss drugs, drug manufacturing regulations, and the role we think medicine should play in our lives. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

The impact of cars on wildlife extends beyond roadkill, affecting species that never venture near roads. Car noise disrupts bird communication and behavior, and tire and brake dust from pollutes waterways with microplastics. In this wide-ranging interview, we talk to the author of Traffication: How Cars Destroy Nature and What We Can Do About It, Paul Donald about how he coined the term "traffication," the history of road ecology, and what we can do about the problem. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

In 1856, Henry Perkin's attempt to synthesize quinine led to something very different: a vibrant purple dye. Perkin’s mauve revolutionized the fashion industry when Queen Victoria wore a dress of the color to her daughter's wedding. And in an ironic twist, synthetic fabric dyes ultimately led to synthetic drugs, including the first antipsychotic. This drug, known by its trade name Thorazine, was a gamechanger. “Nobody thought there could be a drug that would treat schizophrenia effectively,” says sociologist Andrew Scull, “and then suddenly there was.” In this episode we explore the enduring relationship between dyes and drugs, and the role that mistakes and serendipity still play in drug development. Credits Host: Alexis Pedrick Executive Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.  

The color pink has long been in vogue, and when Barbie hit theaters in 2023, its appeal only increased. But its popularity dates back much further than the Mattel doll. In this bonus episode, Dr. Dominique Grisard, a gender studies professor at the University of Basel, discusses the hue and its ties to femininity, class, and Whiteness, as well as how pink has been used to subdue men in detention centers. This episode was inspired by our museum exhibition, BOLD: Color from Test Tube to Textile, on view through August 3, 2024. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

For centuries people have been drawn to the potential healing powers of colored light. From a civil war general to a Thomas Edison wannabe, people have touted it as a medical miracle. Despite claims to the contrary, though, colored light won’t regrow limbs or heal burns. And yet, we are still drawn to the idea that somehow it can fix us. Today there are actual medical studies investigating the health benefits of colored light. So is there any validity to the claims of the past? Can color really heal us? This episode was inspired by our museum exhibition, BOLD: Color from Test Tube to Textile, on view through August 3, 2024. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

In his epic poem, The Odyssey, Homer mentions the colors black, white, red, and yellow. But despite numerous mentions of the brilliant Greek sea and sky, the word blue never makes an appearance.  This omission set off a debate between perception and language that would repeat itself over and over again throughout history: was there something wrong with the ancient Greek’s eyes? If they didn’t name blue, did that mean they couldn’t see it? We treat color like it's a clear measure of whether or not our brains are working the same. We expect an answer we can all agree on. Only it turns out some colors elude us. So when it comes to blue, are we truly seeing things differently or just seeing the same thing and describing it differently? Credits Host: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Color Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions  

In the wake of the murder of George Floyd and the COVID-19 pandemic, there has been a new public interest in health inequities research. With this new focus, there also has come new funding with many researchers and institutions clamoring to receive lucrative funding and recognition in the field, but there are no official guidelines to distinguish a health equity expert. In this episode we sit down with Dr. Elle Lett who coined the term "health equity tourism" to describe when privileged and previously unengaged scholars enter the health equity field without developing the necessary expertise. Credits Hosts: Alexis Pedrick Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producers: Padmini Raghunath & Sarah Kaplan Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions

Of all wealthy countries, the United States is the most dangerous place to have a baby. Our maternal mortality rate is abysmal, and over the past five years it’s only gotten worse. And there are huge racial disparities: Black women are three times more likely to die than white women. Despite some claims to the contrary, the problem isn’t race, it’s racism. In this episode we trace the origins of this harrowing statistic back to the dawn of American gynecology—a field that was built on the bodies of enslaved women. And we’ll meet eight women who have dedicated their lives to understanding and solving this complex problem. Credits Host: Alexis Pedrick  Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.

Certain medical instruments have built-in methods of correcting for race. They’re based on the premise that Black bodies are inherently different from White bodies. The tool that measures kidney function, for example, underestimates how severe some Black patients’ kidney disease is, and prevents them from getting transplants. Medical students and doctors have been trying to do away with race correction tools once and for all. And they’re starting to see some success. About Innate: How Science Invented the Myth of Race “Correcting Race” is Episode 9 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innateis made possible in part by the National Endowment for the Humanities: Democracy demands wisdom. Credits  |   Resource List   |   Transcript Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.   Resource List A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease, by Cynthia Delgado, Mukta Baweja, Deidra C Crews, Nwamaka D Eneanya, Crystal A Gadegbeku, Lesley A Inker, Mallika L Mendu, W Greg Miller, Marva M Moxey-Mims, Glenda V Roberts, Wendy L St Peter, Curtis Warfield, Neil R Powe A Yearslong Push to Remove Racist Bias From Kidney Testing Gains New Ground, by Theresa Gaffney   ‘An entire system is changing’: UW Medicine stops using race-based equation to calculate kidney function, by Shannon Hong  Breathing Race into the Machine: The Surprising Career of the Spirometer from Plantation to Genetics, by Lundy Braun  Expert Panel Recommends Against Use of Race in Assessment of Kidney Function, by Usha Lee McFarling  Hidden in Plain Sight – Reconsidering the Use of Race Correction in Clinical Algorithms, by Darshali A. Vyas, Leo G. Eisenstein, and David S. Jones Medical student advocates to end racism in medicine, by Anh Nguyen  Precision in GFR Reporting Let’s Stop Playing the Race Card, by Vanessa Grubbs  Reconsidering the Consequences of Using Race to Estimate Kidney Function, by Nwamaka Denise Eneanya,  Wei Yang, Peter Philip Reese

When the plague broke out in San Francisco in 1900 the public health department poured all of their energy into stopping its spread in Chinatown, as if Chinatown were the problem. This episode reveals why they did it, what it has to do with race science, and what it tells us about the history of public health. Credits Host: Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.

In 2005 the FDA approved a pill to treat high blood preassure only in African Americans. This so-called miracle drug was named BiDil, and it became the first race-specific drug in the United States. It might sound like a good a good thing, but it had the unintended consequence of perpetuating the myth that race is a biological construct.  Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.   Resource List Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century, by Dorothy Roberts Oprah’s Unhealthy Mistake, by Osagie K. Obasogie Race in a Bottle: The Story of BiDil and Racialized Medicine in a Post-Genomic Age, by Jonathan Kahn Saving Sam: Drugs, Race, and Discovering the Secrets of Heart Disease, by Jay Cohn The Slavery Hypertension Hypothesis: Dissemination and Appeal of a Modern Race Theory, by Jay S Kaufman, Susan A Hall Superior: The Return of Race Science, by Angela Saini

The word “Tuskegee” has come to symbolize the Black community’s mistrust of the medical establishment. It has become American lore. However, most people don’t know what actually happened in Macon County, Alabama, from 1932 to 1972. This episode unravels the myths of the U.S. Public Health Service (USPHS) Syphilis Study (the correct name of the study) through conversations with descendants and historians. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions. Resource List Black Journal; 301; The Tuskegee Study: A Human Experiment Descendants of men from horrifying Tuskegee study want to calm virus vaccine fears, by David Montgomery  Examining Tuskegee: The infamous Syphilis Study and Its Legacy  Nova: The Deadly Deception  Susceptible to Kindness: Miss Evers’ Boys and the Tuskegee Syphis Study  Tuskegee Legacy Stories Under the Shadow of Tuskegee: African Americans and Health Care, by Vanessa Northington Gamble Voices For Our Fathers Legacy Foundation

In 1991, as crews broke ground on a new federal office building in lower Manhattan, they discovered human skeletons. It soon became clear that it was the oldest and largest African cemetery in the country. The federal government was ready to keep building, but people from all over the African diaspora were moved to treat this site with dignity, respect, and scientific excellence. When bioarchaeologist Michael Blakey took over, that's exactly what they got. But it wasn't easy. Credits Host: Alexis Pedrick  Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.   Resource List Archaeology under the Blinding Light of Race, by Michael Blakey African Burial Ground Project: Paradigm for Cooperation? by Michael Blakey The African Burial Ground in New York City: Memory, Spirituality, and Space, by Andrea E. Frohne The African Burial Ground: An American Discovery, documentary film by David Kutz Reassessing the “Sankofa Symbol” in New York's African Burial Ground, by Erik R. Seeman The New York African Burial Ground Final Reports, by multiple authors

In 2019, Abdul-Aliy Muhammad, a community organizer and journalist, learned that the Penn Museum of Archaeology and Anthropology had a collection of skulls that belonged to enslaved people. As Muhammad demanded that the university return these skulls, they discovered that claiming ownership over bodies of marginalized people is not just a relic of the past—it continues to this day. Credits Host: Alexis Pedrick  Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions. Resource List It’s past time for Penn Museum to repatriate the Morton skull collection, by Abdul-Aliy Muhammad Penn Museum seeks to rebury stolen skulls of Black Philadelphians and ignites pushback, by Abdul-Aliy Muhammad Penn Museum owes reparations for previously holding remains of a MOVE bombing victim, by Abdul-Aliy Muhammad City of Philadelphia should thoroughly investigate the MOVE remains’ broken chain of custody, by Abdul-Aliy Muhammad Black Philadelphians in the Samuel George Morton Cranial Collection , by Paul Wolff Mitchell Some skulls in a Penn Museum collection may be the remains of enslaved people taken from a nearby burial ground, by Stephan Salisbury Remains of children killed in MOVE bombing sat in a box at Penn Museum for decades, by Maya Kassutto The fault in his seeds: Lost notes to the case of bias in Samuel George Morton's cranial race science, by Paul Wolff Mitchell She Was Killed by the Police. Why Were Her Bones in a Museum?, by Bronwen Dickey Corpse Selling and Stealing were Once Integral to Medical Training, by Christopher D.E. Willoughby Medicine, Racism, and the Legacies of the Morton Skull Collection, by Christopher D.E. Willoughby Final Report of the Independent Investigation into the City of Philadelphia’s Possession of Human Remains of Victims of the 1985 Bombing of the MOVE Organization, prepared by Dechert LLP and Montgomery, McCracken, Walker & Rhoads LLP, for the city of Philadelphia The Odyssey of the MOVE remains, prepared by the Tucker Law Group for the University of Pennsylvania Move: Confrontation in Philadelphia, film by Jane Mancini and Karen Pomer Let the Fire Burn, film by Jason Osder Philadelphia Special Investigation Commission (MOVE) Records, archival collection at Temple University's Urban Archives

In the 1990s a liberal population geneticist launched the Human Genome Diversity Project. The goal was to sequence the genomes of “isolated” and “disappearing” indigenous groups throughout the world. The project did not go as planned—indigenous groups protested it, and scientists and anthropologists criticized it. This episode examines what went wrong and asks the question: can anti-racist scientists create racist science?  About Innate: How Science Invented the Myth of Race “The Vampire Project” is Episode 4 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innate is made possible in part by the National Endowment for the Humanities: Democracy demands wisdom. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.

In the 1970s Barry Mehler started tracking race scientists and he noticed something funny: they all had the same funding source. One wealthy man was using his incredible resources to prop up any scientist he could find who would validate his white supremacist ideology—and make it seem like it was backed by a legitimate scientific consensus. About Innate: How Science Invented the Myth of Race “Keepers of the Flame” is Episode 3 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innate is made possible in part by the National Endowment for the Humanities: Democracy demands wisdom. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions.   Resource List ‘The American Breed’: Nazi eugenics and the origins of the Pioneer Fund, by Paul Lombardo  The Funding of Scientific Racism: Wickliffe Draper and the Pioneer Fund, by William Tucker The New Eugenics: Academic Racism in the U.S. Today, by Barry Mehler  The Phil Donahue Show  Superior: The Return of Race Science, by Angela Saini

In 1793 a yellow fever epidemic almost destroyed Philadelphia. The young city was saved by two Black preachers, Richard Allen and Absalom Jones, who organized the free Black community in providing essential services and nursing the sick and dying. Allen and Jones were assured of two things: that stepping up would help them gain full equality and citizenship, and that they were immune to the disease. Neither promise turned out to be true.  About Innate: How Science Invented the Myth of Race “Calamity in Philadelphia” is Episode 2 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innate is made possible in part by the National Endowment for the Humanities: Democracy demands wisdom. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer Richard Allen voiceover by Jason Carr “Innate Theme” composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions. Resource List How the Politics of Race Played Out During the 1793 Yellow Fever Epidemic, by Alicia Ault A short account of the malignant fever, lately prevalent in Philadelphia: with a statement of the proceedings that took place on the subject in different parts of the United States, by Mathew Carey Medicalizing Blackness: Making Racial Difference in the Atlantic World, 1780-1840, by Rana A. Hogarth A narrative of the proceedings of the black people, during the late awful calamity in Philadelphia, in the year 1793, by Absalom Jones and Richard Allen Freedom’s Prophet: Bishop Richard Allen, the AME Church, and the Black Founding Fathers, by Richard Newman Observations upon the origin of the malignant bilious, or yellow fever in Philadelphia, and upon the means of preventing it: addressed to the citizens of Philadelphia, by Benjamin Rush Bishop Richard Allen: Apostle of Freedom, produced by Dr. Mark Tyler Transcript

In 2018 ancient DNA researchers revealed their analysis of a 10,000 year old skeleton called Cheddar Man. He was the oldest complete skeleton ever discovered in England, and the revelation that he had dark skin challenged assumptions many people had about what the earliest people in Britain looked like. 

It might seem as though the way we think about race now is how we’ve always thought about it—but it isn’t. Race was born out of the Enlightenment in Europe, along with the invention of modern western science. And it was tied to the politics of the age—imperialism and later slavery. This episode traces the origins of race science to the Enlightenment, examines how the Bible influenced racial theories, and considers how we still have a hard time letting go of the idea of race. About Innate: How Science Invented the Myth of Race “Origin Stories” is Episode 1 of Innate: How Science Invented the Myth of Race, a podcast and magazine project that explores the historical roots and persistent legacies of racism in American science and medicine. Published through Distillations, the Science History Institute’s highly acclaimed digital content platform, the project examines the scientific origins of support for racist theories, practices, and policies. Innate is made possible in part by the National Endowment for the Humanities: Democracy demands wisdom. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath Audio Engineer: Jonathan Pfeffer "Innate Theme" composed by Jonathan Pfeffer. Additional music by Blue Dot Sessions. Special thanks to our colleagues, Jacqueline Boytim and James Voelkel, for their help with this episode. Resource List Archaeology under the Blinding Light of Race, by Michael Blakey  Breathing Race into the Machine: the Surprising Career of the Spirometer from Plantation to Genetics, by Lundy Braun  Divine Variations: How Christian Thought Became Racial Science, by Terence Keel  Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-first Century, by Dorothy Roberts "Jesus Loves the little Children," song by Cedarmont Kids  Medicalizing Blackness: Making Racial Differences in the Atlantic World, 1780-1840, by Rana Hogarth The Nuremberg Chronicle, by Hartmann Schedel Superior: The Return of Race Science, by Angela Saini Find the full transcript here.

What comes to mind when you think of a chemistry lab? Maybe it’s smoke billowing out of glassware, or colorful test tubes, or vats of toxic substances. Chemistry and hazardous solvents just seem to go hand in hand. But chemists like James Mack think there’s a greener way: It’s called mechanochemistry, a kind of chemistry that uses physical force to grind materials instead of solvents. And it’s getting the attention of such huge corporations as Exxon Mobil. Still, some chemists are not ready to give up their traditional techniques. “I thought they were married to the molecules,” says Mack, who is pictured above placing vials into a machine that uses fast-spinning ball bearings to pulverize molecules. “Little did I know they were actually married to the flask.”   Credits Host: Elisabeth Berry Drago Reporter, Producer, and Audio Engineer: Jonathan Pfeffer Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Raghunath

The Disappearing Spoon, a podcast collaboration between the Science History Institute and New York Times best-selling author Sam Kean, returns for its third season on March 8, 2022. To celebrate, our producer, Padmini Parthasarathy, sat down with Kean to talk about his book The Violinist's Thumb: And Other Lost Tales of Love, War, and Genius, as Written by Our Genetic Code. This interview is a great companion piece for the new season of The Disappearing Spoon, which tackles all sorts of strange and interesting stories about the geniuses we know well—from Einstein and his great scientific blunder that turned out to be correct, to Monet and the cataracts that almost made him put down his brush forever. Listen as Kean talks about violin protégé Niccolo Paganini, whose genes were both a blessing and a curse, the scientific arms race that led to the mapping of the human genome, and the sometimes-murky lines between human and non-human. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Associate Producer: Padmini Parthasarathy Audio Engineer: Jonathan Pfeffer Photo: Wikimedia Commons

In this episode of The Disappearing Spoon, Sam Kean talks about Alessandro Moreschi, the so-called Angel of Rome. His voice earned him fame and money. So what's the secret behind the voice? What was his trick? It turns out that his trick can also make you taller and prevent baldness. The only catch: it requires castration. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

In this episode of The Disappearing Spoon, Sam Kean talks about the strange origin story of the American Medical Association. The creation of this powerful medical society can be traced back to a duel between two doctors at Transylvania University in Kentucky. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

In this episode of The Disappearing Spoon, Sam Kean talks about Hermann Muller, a geneticist who in the 1920s discovered that radiation causes genetic mutations. This discovery happened around the same time that other geneticists were starting to link cancer with genetic mutations. Had both of these parties communicated they would have gotten a 50-year head start in cancer research. So why didn't scientists make this realization sooner? It turns out that Muller was a real jerk. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

On this episode of The Disappearing Spoon, Sam Kean talks about a murder mystery that rocked Boston in 1849. Harvard University alum and physician George Parkman had gone missing. The last place he was seen alive was at the Harvard medical building, which had plenty of bodies, but police couldn't find Parkman’s there. That is until a janitor intervened and implicated a medical school professor. The ensuing murder trial was a media circus equivalent to the O. J. Simpson trial. And just like that trial, it also familiarized the layperson with forensic and anatomical sciences. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer Photo: Wellcome Collection

In this episode of The Disappearing Spoon, Sam Kean breaks down the history of nitrocellulose. This thick, transparent liquid was the world’s first plastic and could be shaped into anything, including billiard balls and photography film. With nitrocellulose film, you could run reels of pictures together quickly, which gave birth to the first movies. The only fatal flaw with this plastic is that it’s also extremely combustible—so much so that it can burn underwater once it gets going. This led to notable tragedies in movie theaters, as well as in hospitals that used nitrocellulose X-rays such as the Cleveland Clinic Hospital, where 122 people died in a fire in 1929. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

In this episode of The Disappearing Spoon, Sam Kean talks about Mary Ward, a budding naturalist and astronomer from Ireland. She spent a lot of time observing plants and animals through a microscope and published a book of detailed sketches that dazzled readers and colleagues in the 1800s. However, her career was cut short by a strange curiosity of that time period: the automobile. They weren’t the same cars that are around today, but her death was the first car death recorded in history, and it foreshadowed the carnage the automobile continues to leave behind. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

In this episode of The Disappearing Spoon, Sam Kean talks about memory fugues, a psychological disorder that wipes out biographical information from people’s brains. It is estimated that roughly 1 in 100,000 people seeking help for mental disorders have them. This disorder happens worldwide and it usually afflicts people in their 20s. Scientists have only recently started to piece together what is going on in the brains of those impaired by it. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

On this episode of The Disappearing Spoon, Sam Kean delves deep into the science behind the evolution of animal and human bodies. Like animals, human bodies have also evolved to adhere to the demands of ever-changing climates. This raises a question: how will human bodies respond to climate change? Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

In this episode of Disappearing Spoon, Sam Kean discusses the horrors of a particular genetic disease that was, literally, sweeping through London in the 1700s. In 1666, the Great Fire of London consumed about 13,000 homes and caused the modern equivalent about $1.3 billion in damage. After the Great Fire, London officials made chimneys mandatory in all homes and buildings. All these new chimneys meant there was a big demand for sweepers. Who did they employ to clean these narrow, soot-filled chimneys you ask? Very young boys. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Animal trials have always been part of society, but we are not talking about the ones with lab mice. In medieval times dozens of animals were tried in human courts for committing human crimes. It sounds silly, but the practice raises an uncomfortable question that we are still grappling with today: if we hold animals accountable in court, doesn’t that mean that they deserve some sort of legal protection? We kill them for food and skin them for leather after all. What about medical and product trials that sacrifice thousands of animals despite the fact that they have had diminishing returns throughout the years? Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

The Disappearing Spoon, a podcast collaboration between the Science History Institute and New York Times best-selling author Sam Kean, returns for its second season on October 5, 2021. To celebrate, our producer, Rigoberto Hernandez, sat down with Kean to talk about his new book The Icepick Surgeon: Murder, Fraud, Sabotage Piracy, and Other Dastardly Deeds Perpetrated in the Name of Science. This interview is a great companion piece for The Disappearing Spoon series since some of the stories in the book relate directly to some of the stories in the upcoming season. In this interview Kean talks about some of the case studies in his book, including how Thomas Edison shifted his ethics on the death penalty because of a grudge, how a part-time chemist from Philadelphia became an unlikely spy, and how an American doctor purposefully infected people in Guatemala with venereal diseases—all in the name of science. Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

The human brain is mysterious and complicated. So much so, one might be tempted to argue that it only makes sense that we still don’t have a cure for Alzheimer’s disease, despite decades of research. But this isn’t the whole story. We’ve partnered with Vox’s Unexplainable science podcast to talk about how Alzheimer’s researchers have been stubbornly pursuing a single theory for decades. The Amyloid Hypothesis is the reigning champ amongst pharmaceutical companies and scientific scholars and it has pushed all other theories to the wayside. Over the years scientists have developed many drugs based on the Amyloid Hypothesis but the the clinical trials keep failing. Now some researchers are starting to wonder if the reason we still don’t have a cure is that we’ve put all of our scientific eggs in one faulty basket.  You can hear more about the Alzheimer’s disease on the previous Distillations Podcast episodes: The Alzheimer’s Copernicus Problem Parts 1 and 2. Credits: Distillations: Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer Unexplainable: This episode was produced by Rigo Hernandez, Alexis Pedrick, Dylan Scott, and Byrd Pinkerton. It was edited by Noam Hassenfeld and Brian Resnick, with help from Meradith Hoddinott and Mandy Nguyen, who also did the fact checking. Noam Hassenfeld wrote the music, Cristian Ayala did the mixing and sound design.  Image courtesy of Vox Media Group.

Ever since the book A Discovery of Witches debuted in 2011, the All Souls franchise has taken on a life of its own with devoted fans all over the world. The TV show and annual All Souls Con—which the Science History Institute occasionally hosts—is based on the trilogy of books about witches, vampires, and demons by author Deborah Harkness. Distillations sat down with Jen Daine and Cait Parnell, the hosts of the All Souls podcast, Chamomile and Clove; art historian Stephenie McGucken; and medievalist actor, journalist, and author Sarah Durn to talk about the series’ alchemical roots, the material culture in the TV show, and how the book’s found-family theme mirrors the fandom. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Since humans have been living we’ve also been dying—best case scenario: after eight or nine decades and plenty of good times. But we’re not wholly content with that. Never have been, probably never will be. In fact, working on how not to die is one of the most human things about us. It’s occupied the minds of everyone from ancient Chinese emperors and medieval European alchemists to now, Silicon Valley entrepreneurs. They think it’s within sight and completely different from how this quest was approached in the past. Or is it? Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Jeremiah McCall is a history teacher at Cincinnati Country Day School and the author of Gaming the Past: Using Video Games to Teach Secondary School. He talked to Distillations about what it's like to use video games in his history classes, the criteria he uses in choosing games, and why he likes his students to question the media they are consuming. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

The pandemic made gamers out of many Americans, including our producer, Rigoberto Hernandez. He played a lot of historical video games and it got him thinking: can you learn history from video games even though they are obviously fiction? Throughout history there have been many moral panics about people consuming historical fiction and taking what they read and watch as fact, so how do video games stack up? It turns out that they can empower players in better ways than TV shows, films, and books. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Anna Reeser is a historian of technology and Laila McNeil is a historian of science. Together they co-founded and are editors-in-chief of Lady Science, an independent magazine about women, gender, history, and popular culture of science. Now the duo has a new book titled Forces of Nature: The Women Who Changed Science. They talked to us about moving beyond biographies, how women who had knowledge about the natural world are suspect, and reintegrating women’s history into the mainstream.

For decades, the official fire policy of the Forest Service was to put out all fires as soon as they appeared. That might seem logical, but there is such a thing as a good fire, the kind that helps stabilize ecosystems and promotes biodiversity. Native American communities understood this and regularly practiced light burning. So why did the Forest Service ignore this in favor of unabated fire suppression? In 1910 a massive fire known as “the big blow up” or “the big burn” devastated northern Idaho and Western Montana. It left a huge mark on the then five-year-old Forest Service and had consequences we still see today. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Ghost hunters on television all seem to have a common goal: to prove that ghosts are real using sophisticated, yet inexact technology. Colin Dickey, the author of Ghostland: An American History in Haunted Places, says this is not an accident. The relationship between technology and ghosthunters is as old as the telegraph. But Dickey is not interested in proving they are real; he is fascinated with what the ghost stories we tell reveal about our society. Credits: Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

The 19th century was a time of rapid technological leaps: the telegraph, the steam boat, the radio were invented during this century. But this era was also the peak of spiritualism: the belief that ghosts and spirits were real and could be communicated with after death. Seances were all the rage. People tried to talk to their dead loved ones using Ouija boards and automatic writing. Although it might seem contradictory, it's not a coincidence that this was all happening at the same time. There have always been questions about life after death, but in the 19th century people found new ways to investigate them using these new cutting-edge technological tools. And part of it was that some of these new tools felt supernatural in and of themselves. The radio, the telegraph, the phonograph: these allowed us to speak over inconceivable distances, communicate instantly from an ocean away, and even preserve human voices in time and after death. But something else was going on in the 19th century. The people who were trying to figure out if we could really talk to ghosts were not just on the fringes - many of them were scientists. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer Music: "Lanterns Ascending" - Jerry Lacey "Shapeshifter" - Martin Klem "Behind that Door" - Farrell Wooten "First Sign" - Mahlert "Black Core" - Guy Copeland "Maximum State" - Ethan Sloan "String Quartet No. 3, Op. 41 Adagio Part 4" - Traditional "Chronicles of a Mystic Dream" - Grant Newman "Deep Cellar" - Experia "Shapeless Inside" - Cobby Costa "Aquamarine" - Mahlert "Decomposed" - Philip Ayers Special thanks to Charley Levin and Lena Kidd-Nicolella for their portrayal of Maggie and Kate Fox. Image courtesy of Wikimedia Commons.

In the 19th century a mysterious illness afflicted rural New England. Often called the Great White Plague for how pale it made its victims, it was also called “consumption” because of the way it literally consumed people from the inside out, gradually making them weaker, paler, and more lifeless until they were gone. Today we know it as tuberculosis, an infectious bacterial disease that attacks the lungs and causes a hacking cough, a wasting fever, and night sweats. But back then the main suspect was vampires. Credits Hosts: Alexis Pedrick and Elisabeth Berry Drago Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Last year Distillations talked to people who have special insight into the coronavirus crisis—biomedical researchers, physicians, public health experts, and historians. In this episode we talk to Stéphane Bancel, CEO of Moderna, a biotech company that developed one of the three emergency-approved COVID-19 vaccines in the United States. The Moderna vaccine is unique in that it uses a new technology that has been decades in the making called messenger RNA, or mRNA. Bancel reflects on the development timeline of the vaccine: from learning about the virus while reading the Wall Street Journal in 2019 to the moment he finally got his own shot at a Moderna facility. He talks about the promise of mRNA and what’s ahead for Moderna. Credits Host: Alexis Pedrick Senior Producer: Mariel Carr  Producer: Rigoberto Hernandez Researcher: Jessica Wade Audio Engineer: Jonathan Pfeffer

In the 1700s human dissection was a big taboo—people feared that it would leave their bodies mangled on Judgment Day, when God would raise the dead. As a result, government officials banned most dissections. This led to some unintended consequences, most notably a shortage of bodies for anatomists to dissect. To meet the heightened demand, a new profession emerged: grave-robbers. These so-called resurrectionists dug up the bodies of poor people to sell to anatomists, which led to riots in the streets. Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer

Credits Host: Sam Kean Senior Producer: Mariel Carr Producer: Rigoberto Hernandez Audio Engineer: Jonathan Pfeffer Music: "Trois Gnossiennes 3," "Stately Shadows," "Darklit Carpet," "Vernouillet," and "Tossed" by Blue Dot Sessions. "Conjunto Sol del Peru," by Pockra (Vol. 2: Musica de los Andes Peruanos). "Conjunto Sol del Peru," by Wuaylias Tusy (Vol. 2: Musica de los Andes Peruanos). "Conjunto Sol del Peru," by Ckashampa (Vol. 2: Musica de los Andes Peruanos) Image courtesy of the Wellcome Collection.