with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2018 at our annual innovation Summit, and features economist Tyler Cowen interviewing Ben and Marc about everything from their partnership and how it works to talent, tech trends, and software eating culture. You can find other episodes in this series at a16z.com/10.

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Steven Johnson (@stevenbjohnson) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2017 at our annual innovation Summit, and features technology writer Steven Johnson interviewing Ben and Marc about everything from their relationship to creative inspirations. You can find other episodes in this series at a16z.com/10.

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2016 -- on the 5-year anniversary of Marc’s Wall Street Journal op-ed on “Why software is eating the world” -- and features Sonal Chokshi and Scott Kupor interviewing Ben and Marc about what’s changed since, and how software is programming the world... in everything from simulations to distributed systems to other key computing shifts. You can find other episodes in this series at a16z.com/10.

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Michael Copeland Continuing our 10-year anniversary series since the founding of Andreessen Horowitz (aka "a16z"), we’re resurfacing some of our previous episodes featuring Andreessen Horowitz founders Marc Andreessen and Ben Horowitz. This episode was actually recorded in 2014, on the 5-year anniversary of the firm, and features Michael Copeland interviewing Ben and Marc about disruption theory, as well as key traits of entrepreneurs. You can find other episodes in this series at a16z.com/10.

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Stewart Butterfield (@stewart) A lot in technology -- and venture -- happens in decades. New cycles of technology come and go, including some secular shifts; a new generation of founders matures; and so much more changes. So when Andreessen Horowitz (dubbed with the numeronym "a16z") was founded a decade ago as of this month, the tech landscape looked very different between then and now: Not only had the global economy just seen a recession, but trends like mobile and cloud and even social were just taking off. Now, 10 years later, what's changed -- not just in tech, but in profiles of entrepreneurs? And what's changed in the firm itself, given that Marc and Ben -- the Andreessen and the Horowitz -- were yet again entrepreneurs in founding the firm too? As another repeat entrepreneur from then to now, guest host Stewart Butterfield, CEO of Slack, interviews the a16z co-founders in this special episode of the a16z Podcast to commemorate our 10th anniversary. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments for which the issuer has not provided permission for a16z to disclose publicly as well as unannounced investments in publicly traded digital assets) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Two recent scientific journal papers show what's possible when CRISPR moves from cutting DNA tool to a full-fledged platform -- expanding its toolkit for medicine across R&D, therapeutics, and diagnostics: "Transposon-encoded CRISPR-Cas systems direct RNA-guided DNA integration" in Nature -- by Sanne Klompe, Phuc Vo, Tyler Halpin-Healy, and Samuel Sternberg (of Columbia University) "RNA-guided DNA insertion with CRISPR-associated transposases" in Science -- by Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan Schmid-burgk, Kira Makarova, Eugene Koonin, and Feng Zhang (of the Broad Institute) What do these two papers -- both about techniques for getting rid of the need to cut the genome to edit it -- make possible going forward, given the ongoing shift of biology becoming more like engineering? Where are we in the wave of the genome engineering "developer community" building on top of CRISPR with a constantly growing suite of programmable functionalities? a16z bio general partner Jorge Conde and bio deal team partner Andy Tran chat with Hanne Tidnam about these trends -- and these two papers -- in this short internal hallway-style conversation, part of our new a16z Journal Club series. This podcast is also part of our new a16z bio newsletter, which you can sign up for at a16z.com/subscribe

Synthetic fraud—yes, it's a thing: a new evolution of consumer fraud that’s been emerging in financial services, to the tune of $1-$2B a year. In this episode of the a16z Podcast, Naftali Harris, co-founder and CEO of Sentilink, which builds technology to detect and stop synthetic fraud, talks with a16z's Hanne Tidnam and operating partner for information security Joel de la Garza all about what this new kind of fraud is. Where did this new form of fraud come from, and why is it on the rise? Who are true victims here (hint: it's not the Joneses... or maybe it is!). And what is the fundamental security issue really at the heart of it all? The conversation covers the fascinating life cycle of this long con: how these “synthetic” identities get made, incubated, and finally busted out… and some of the wildest stories (and art of storytelling!) behind the strangest fraud rings we've seen. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information. Where did this new form of fraud come from, and why is it on the rise? Who are true victims here (hint: it's not the Joneses... or maybe it is!). And what is the fundamental security issue really at the heart of it all? The conversation covers the fascinating life cycle of this long con: how these “synthetic” identities get made, incubated, and finally busted out… and some of the wildest stories (and art of storytelling!) behind the strangest fraud rings we've seen.

How have we gotten to where were are with machine learning? Where are we going? a16z Operating Partner Frank Chen and Carnegie Mellon professor Tom Mitchell first stroll down memory lane, visiting the major landmarks: the symbolic approach of the 1970s, the "principled probabalistic methods" of the 1980s, and today's deep learning phase. Then they go on to explore the frontiers of research. Along the way, they cover: How planning systems from the 1970s and early 1980s were stymied by the "banana in the tailpipe" problem How the relatively slow neurons in our visual cortex work together to deliver very speedy and accurate recognition How fMRI scans of the brain reveal common neural patterns across people when they are exposed to common nouns like chair, car, knife, and so on How the computer science community is working with social scientists (psychologists, economists, and philosophers) on building measures for fairness and transparency for machine learning models How we want our self-driving cars to have reasonable answers to the Trolley Problem, but no one sitting for their DMV exam is ever asked how they would respond How there were inflated expectations (and great social fears) for AI in the 1980s, and how the US concerns about Japan compare to our concerns about China today Whether this is the best time ever for AI and ML research and what continues to fascinate and motivate Tom after decades in the field The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Tony Blair (@InstituteGC), Scott Kupor (@skupor), and Sonal Chokshi (@smc90) If the current pace of tech change is the 21st-century equivalent of the 19th-century Industrial Revolution — with its tremendous economic growth and lifestyle change — it means that even though it’s fundamentally empowering and enabling, there’s also lots of fears and misconceptions as well. That’s why, argues former U.K. prime minister Tony Blair (who now has an eponymous Institute for Global Change), we need to make sure that the changemakers — i.e., technologists, entrepreneurs, and quite frankly, any company that wields power — are in a structured dialogue with politicians. After all, the politician’s task, observes Blair, is “to be able to articulate to the people those changes and fit them into a policy framework that makes sense”. The concern is that if politicians don't understand new technologies, then "they'll fear it; and if they fear it, they'll try and stop it" -- and that's how we end up with pessimism and bad policy. Yet bad regulations often come from even the very best of intentions: Take for example the case of Dodd-Frank in the U.S., or more recently, GDPR in Europe -- which, ironically (but not surprisingly) served to entrench incumbent and large company interests over those of small-and-medium-sized businesses and startups. And would we have ever had the world wide web today if we hadn't had an environment of so-called "permissionless innovation", where government didn't decide up front how to regulate the internet? Could companies instead be more inclusive of stakeholders, not just shareholders, with better ESG (environment, social, governance)? Finally, how do we ensure a spirit of optimism and focusing on leading vs. lagging indicators about the future, while still being sensitive to short-term displacements, as with farmers during the Industrial Revolution? This hallway-style style episode of the a16z Podcast features Blair in conversation with Sonal Chokshi and a16z managing partner Scott Kupor -- who has a new book, just out, on Secrets of Sand Hill Road: Venture Capital and How to Get It, and also often engages with government legislators on behalf of startups. They delve into mindsets for engaging policymakers; touch briefly on topics such as autonomous cars, crypto, and education; and consider the question of how government itself and politicians too will need to change. One thing's for sure: The discussion today is global, beyond both sides of the Atlantic, given the flow of capital, people, and ideas across borders. So how do we make sure globalization works for the many... and not just for the few.  image credit: Benedict Macon-Cooney The views expressed here are those of the individual personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors and may not under any circumstances be relied upon when making a decision to invest in any a16z funds. PLEASE SEE MORE HERE: https://a16z.com/disclosures/

with Eric Topol (@EricTopol) and Vijay Pande (@vijaypande) Artificial intelligence is coming to the doctor’s office. In this episode, Dr. Eric Topol, cardiologist and chair of innovative medicine at Scripps Research, and a16z’s general partner on the Bio Fund Vijay Pande, have a conversation around Topol’s new book, Deep Medicine: How Artificial Intelligence Can Make Healthcare Human Again. What is the impact AI will have on how your doctor engages with you? On the nature of the doctor's visit as a whole? How will AI impact not just doctor-patient interactions, but diagnosis, prevention, prediction, medical education, and everything in between? Topol and Pande discuss how AI’s capabilities for deep phenotyping will shift our thinking from population health to understanding the medical health essence of you, how the industry might respond and the challenges in integrating and introducing the technology into today’s system—and ultimately, what that the doctor’s visit of the future might look like.

Want actionable advice from a founder who has built multiple tech companies and has invested the time to be open, introspective, and transparent about lessons learned? In this episode (which originally aired as a YouTube video), a16z General Partner Andrew Chen (@@andrewchen) talks with Justin Kan (@justinkan). Justin is a repeat entrepreneur who co-founded Kiko Software (a Web 2.0 calendar that pre-dated Google Calendar by 4 years); Justin.tv (a lifecasting platform); Twitch.tv (a live streaming platform for esports, music, and other creatives now part of Amazon); Socialcam; and now Atrium, a software-powered law firm for startups. Justin reflects on his journey and shares 10 + 1 lessons he’s learned: The paradox of choice: choosing a focus Tradeoffs between B2B versus B2C companies Market risk vs execution risk Fundraising strategy: go big or stay lean? Managing the stress of being a startup CEO (again!) Seeking out mentors, coaches, and peers for help Intentionally designing a culture to avoid the pitfalls of “culture eating strategy” Things he’s still doing in his latest startup—and things he’s doing very differently Managing higher expectations What he’s reading and listening to Bonus: advice he’d give his 20-year old self The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Vijay Pande (@vijaypande) and Bharath Ramsundar Deep learning has arrived in the life sciences: every week, it seems, a new published study comes out... with code on top. In this episode, a16z General Partner Vijay Pande and Bharath Ramsundar talk about how AI/ML is unlocking the field in a new way, in a conversation around their book, Deep Learning for the Life Sciences: Applying Deep Learning to Genomics, Microscopy, Drug Discovery, and More (also co-authored with Peter Eastman and Patrick Walters. So -- why now? ML is old, bio is certainly old. What is it about deep learning's evolution that is allowing it to finally making a major impact in the life sciences? What is the practical toolkit you need, the right kinds of problems to attack, and the right questions to ask? How is the hacker ethos coming to the world of biology? And what might “open source biology” look like in the future?

with Van Jones (@VanJones68), Shaka Senghor (@ShakaSeghnor), and Chris Lyons (@clyons) True redemption can be hard to come by in our justice system today. And yet, we need it more than ever before. In this episode (based on an event hosted by Andreessen Horowitz's Cultural Leadership Fund), CNN news commentator and author Van Jones and Shaka Senghor, author of the New York Times bestseller Writing my Wrongs and director's fellow of the MIT Media Lab, discuss the U.S. prison system; the human potential for redemption; and how we begin to go about normalizing restorative justice in our society. The conversation, introduced by a16z partner Chris Lyons, followed screening of an episode of Van Jones' new series, The Redemption Project. The eight-part series looks at the families of victims of a life-altering crime as they come together to meet their offender; this episode featured the meeting between a police officer along with the man who shot him as a young boy of 17 years, decades earlier. The episode also includes two spoken word performances before and after the conversation, from two formerly incarcerated artists: first, Kevin Gentry, with "My Heart"; and second, Missy Hart, with "Bloom: A Trilogy." Both are contributors to The Beat Within, a publication and organization that serves youth across California country juvenile halls and encourages literacy, self-expression, and community.

with Andrew Lo (@AndrewWLo) and Jorge Conde (@JorgeCondeBio) The advent of new gene and cell therapies are beginning to approach that holy grail of medicine—that of a possible cure. But they are also more expensive than any medicines ever sold before. In this episode, MIT economist Andrew Lo and a16z General Partner on the Bio Fund Jorge Conde discuss how exactly we place an economic value on a cure; the questions we still need to figure out, like who should pay for what and how; and how we need to start thinking about handling the coming influx of highly priced medicines like these into our healthcare system. If we think about these payments as a kind of 'mortgage for a cure,' what happens when your gene therapy mortgage defaults? How would payment plans like these move between insurance plans? Lo and Conde also discuss the broader context in our healthcare system, the economics and risk of drug discovery and development overall – and finally, how our markets might just function more like biological systems than anything else.

with Laurene Powell Jobs (@LaurenePowell) and Ben Horowitz (@bhorowitz) Laurene Powell Jobs is, among many other things, founder and President of the Emerson Collective -- the social impact firm she founded to drive change and reform through philanthropy, investing, and policy solutions. In this episode of the a16z Podcast, Ben Horowitz interviews Powell Jobs on everything from what made her who she was, growing up in the working class rural hills of New Jersey, to how the Emerson Collective does what it does (and why it's a collective, for that matter). What motivates the investments the Emerson Collective makes—and what do they all share in common, across such a broad range of areas, from education to immigration to media? This conversation originally took place at our annual innovation a16z Summit in November 2018 — which features a16z speakers and invited experts from various organizations discussing innovation at companies small and large.

with David Ulevitch (@davidu) and Sonal Chokshi (@smc90) Since the startup (and founder) journey doesn't go neatly linear from technical to product to sales, tightening one knob (whether engineering or marketing or pricing & packaging) creates slack in one of the other knobs, which demands turning to yet another knob. So how do you know what knob to focus on and when? How do you build the right team for the right play and at the right time? It all depends on "What time is it": where are you on the journey, and where do you want to go... In this episode of the a16z Podcast, general partner David Ulevitch (in conversation with Sonal Chokshi) shares hard-earned lessons on these top-of-mind questions for founders; as well as advice on other tricky topics, such as pricing and packaging, balancing between product visionary vs. product manager, how to manage your own time (and psychology!) as your company grows, and more. Much of this is based on his own up-and-down, inside-outside, big-small-big-small, long journey as CEO (and CTO) for the company he co-founded, OpenDNS. The company was later acquired by Cisco after it pivoted from consumer to enterprise. Speaking of, what are the latest shifts and nuances in selling and buying enterprise products, beyond the phrase "consumerization of enterprise"? Or beyond the cliché of "design thinking" -- how does one go beyond user experience and beyond things like fun gifs (which are pronounced, ahem, "jifs") to focusing on the whole customer experience, and earning the right to be complicated? All this and more in this episode... plus the magic 5 words that will help any CEO (and anyone, really). The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

Do you sometimes wish you had been born in a different decade so you could have worked on the fundamental building blocks of modern computing? How fun, challenging, and fulfilling would it have been to work on semiconductors in the 1950s or Unix in the 1960s (both at Bell Labs) or personal computers at the Homebrew Computer Club in the 1970s or on the Internet browser at the University of Illinois at Urbana-Champaign (and later Mountain View, CA) in the 1990s? Good news: it’s not too late. There’s a new computing platform being built today by a vibrant and rapidly growing cryptocurrency community. You might have noticed some of your coworkers and friends leaving big stable tech companies to join crypto startups. In this episode, which originally appeared on YouTube, a16z crypto partner Ali Yahya (@ali01) talks with Frank Chen (@withfries2) about five challenging problems the community is trying to solve right now to enable a new computing platform and a new set of killer apps: *Scaling decentralized computing *Scaling decentralized storage *Scaling decentralized networks *Establishing trusted identities and reputation *Establishing trusted governance models If you’re a software engineer, product manager, UX designer, investor, or tech enthusiast who thrives on the particular challenges of building a new computing platform, this is the perfect time to join the crypto community. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Emily Oster (@ProfEmilyOster) and Hanne Tidnam (@omnivorousread) Are chia seeds actually that good for you? Will Vitamin E keep you healthy? Will breastfeeding babies make them smarter? There’s maybe no other arena where understanding what the evidence truly tells us is harder than in health… and parenting. And yet we make decisions based on what we hear about in studies like the ones listed above every day. In this episode, Brown University economics professor Emily Oster, author of Expecting Better and the recently released book Cribsheet: A Data-driven Guide to Better, More Relaxed Parenting, from Birth to Preschool, in conversation with Hanne Tidnam, dives into what lies beneath those studies... and how to make smarter decisions based on them (or not). Oster walks us through the science and the data behind the studies we hear about -- especially those hot-button parenting issues that are murkiest of all, from screen time to sleep training. How we can tell what’s real and what’s not? Oster shows us the research about how these guidelines and advice that we are "supposed" to follow get formalized and accepted inside and outside of healthcare settings -- from obstetrics practices to pediatrics to diet and lifestyle; how they can (or can’t) be changed; and finally, how the course of science itself can be influenced by how these studies are done.

with @annieduke, @pmarca, and @smc90 Every organization, whether small or big, early or late stage -- and every individual, whether for themselves or others -- makes countless decisions every day, under conditions of uncertainty. The question is, are we allowing that uncertainty to bubble to the surface, and if so, how much and when? Where does consensus, transparency, forecasting, backcasting, pre-mortems, and heck, even regret, usefully come in?Going beyond the typical discussion of focusing on process vs. outcomes and probabilistic thinking, this episode of the a16z Podcast features Thinking in Bets author Annie Duke -- one of the top poker players in the world (and World Series of Poker champ), former psychology PhD, and founder of national decision education movement How I Decide -- in conversation with Marc Andreessen and Sonal Chokshi. The episode covers everything from the role of narrative -- hagiography or takedown? -- to fighting (or embracing) evolution. How do we go from the bottom of the summit to the top of the summit to the entire landscape... and up, down, and opposite?The first step to understanding what really slows innovation down is understanding good decision-making -- because we have conflicting interests, and are sometimes even competing against future versions of ourselves (or of our organizations). And there's a set of possible futures that result from not making a decision as well. So why feel both pessimistic AND optimistic about all this??

In a followup to one of our most popular podcast episodes which originally aired in April 2017 (https://a16z.com/2017/04/03/cryptocurrencies-protocols-appcoins/), a16z Crypto Fund General Partner Chris Dixon returns to talk with Olaf Carlson-Wee of Polychain Capital in a free-wheeling conversation about the seven major trends they see happening in blockchain computing now as we shift from basic protocol design to pragmatic product launches: Improving developer productivity Scaling out versus scaling up On-chain governance Proof of Stake Networks, and especially their resilience to attacks 2017: year of of fund raising, 2019: year of launches Autonomous and re-mixable code Killer apps: distributed finance and beyond This conversation was originally recorded for our YouTube channel: https://www.youtube.com/c/a16zvideos The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.)Past performance is not indicative of future results. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see a16z.com/disclosures for additional important information.

As companies digitize, they change the way they make decisions: decisions are made lower in the organization, based on data, and increasingly automated. This creates opportunities for startups creating new ways to collect and analyze data to support this new style of decision making. In this episode (which originally aired as a YouTube video), Jad Naous (@jadtnaous) ‏and Frank Chen (@withfries2) discuss this change and the startup opportunities these changes create. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.)Past performance is not indicative of future results. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see a16z.com/disclosures for additional important information.

with Jorge Conde (@JorgeCondeBio), Julie Yoo (@julesyoo), and Hanne Tidnam (@omnivorousread) Building a software company in healthcare is hard -- and comes along with unique challenges no other entrepreneurs face. In this conversation, a16z bio general partner -- and previous founder of genomics company Knome -- Jorge Conde; and a16z bio partner and former founder Julie Yoo (of patient provider matching system, Kyruus) share their mistakes and hard earned lessons learned with a16z partner Hanne Tidnam. Why is this so damn hard? How should founders think about this space differently? What are the specific things that healthcare founders can do -- when, where, and why? You'll wish you only knew this when you started your own company!

Join longtime Apple software engineer Ken Kocienda in conversation with a16z Deal and Research operating partner Frank Chen for an insider’s account of how Apple designed software in the golden age of Steve Jobs, spanning products like the first release of Safari on MacOS to the first few releases of the iPhone and iOS (very first codename: "Purple"). Ken vividly shares about the creative process, how teams were organized, what it was like demo'ing to Steve Jobs, and many other fun stories. This episode originally aired as a YouTube video, and throughout, we repeatedly probe the question: is Apple's obsession with secrecy during the product development process a feature or a bug?

In this episode of the a16z Podcast -- which originally aired as a video on YouTube -- general partner Alex Rampell (and former fintech entrepreneur as the CEO and co-founder of TrialPay) talks with operating partner Frank Chen about the quickly changing fintech landscape and, even more importantly, why the landscape is changing now. Should the incumbents be nervous? About what, exactly? And most importantly, what should big companies do about all of this change? But the conversation from both sides of the table begins from the perspective of the hungry and fast fintech startup sharing lessons learned, and then moves to more concrete advice for the execs in the hot seat at established companies. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.) Past performance is not indicative of future results. Any charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information.

with Nick Quah (@nwquah), Connie Chan (@conniechan), and Sonal Chokshi (@smc90) It's a podcast about podcasting! About the state of the industry, that is. Because a lot has changed since we recorded "a podcast about podcasts" about four years ago: podcasts, and interest in podcasting -- listening, making, building -- is growing. But by how much, exactly? (since various stats are constantly floating around and often out of context); and what do we even know (given that no one really knows what a download is)?And in fact, how do we define "podcasts": Should the definition include audio books... why not music, too, then? So much of the podcasting ecosystem -- from editing tools to the notion of a "CD phase" to music companies like Spotify doing more audio deals -- stems from the legacy of the music industry. But other analogies -- like that of the web and of blogging! -- may be more useful for understanding the podcasting ecosystem, too. Heck, we even throw in an analogy of container ships (yes, the ocean kind!) to help out there.If we really think medium-native -- and borrow from other mediums and entertainment models, like TV and streaming and even terrestrial radio -- what may or may not apply to podcasting as experiments evolve? In this hallway-style jam of an episode, Nick Quah (writer and publisher of Hot Pod) joins a16z general partner Connie Chan (who covers consumer startups among other things) in conversation with Sonal Chokshi (who is also showrunner of the a16z Podcast) to talk about all this and more. We also discuss the obvious and the not-so-obvious aspects of monetization, discovery, search, platforms... and where are we in the cycles of industry fragmentation vs. consolidation, bundling vs. unbundling, more? And where might opportunities for entrepreneurs, toolmakers, and creators lie? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.)Past performance is not indicative of future results. Any charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information.

with Benedict Evans (@benedictevans) and Steven Sinofsky (@stevesi) What does Apple's recent event — in which a range of new services was announced, from Apple News Plus to Apple TV Plus to the Apple card — mean for the company's overall strategy and tactics? In this another of a16z's 'hallway conversations', Benedict Evens and Steven Sinofsky discuss the build up, announcements, and postmortem of the recent Apple event, and consider what it all means in terms of a big company's evolution into services. How many different places is Apple now putting a tap into the tree, with new subscriptions available? What’s the positioning underlying all those different services, from a new credit card to new magazines and content, all bundled up together? The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates.This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investor or prospective investor, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund which should be read in their entirety.)Past performance is not indicative of future results. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Please see https://a16z.com/disclosures for additional important information.

with Safi Bahcall (@safibahcall), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) A "moonshot" is a destination (like going to the moon, quite literally) -- but nurturing "loonshots" (which often involves a number of stumbles along the way) is how we get there. This goes beyond the trite mantra of failing fast! It is about not having "false fails" or not killing the seemingly small ideas that could lead to outsized yet unexpected outcomes, observes Safi Bahcall (physicist, ex-startup founder, and CEO of a public biotech company), author of the new book, Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries.So in this episode of the a16z Podcast -- in conversation with a16z bio general partner Vijay Pande and Sonal Chokshi -- Bahcall shares why concepts like "disruptive innovation" cause him gas; why doing market projections can sometimes be crap; and why most management books that focus on culture are b.s.Because CEOs and culture, argues Bahcall, do not control organizational behavior... but hidden incentives, "phase transitions", and specific control parameters do. So how can organizations -- of any size, big or small -- be in two states at the same time: both fluid and stable, soft and solid, with high entropy yet bound energy, and both artists and soldiers? The answer may be in a more scientific, less "squishy" framework for management at the intersection of physics and economics. Big empires always miss the small but important new ideas... can this be why?

with Brian Koppelman (@briankoppelman), Marc Andreessen (@pmarca), and Sonal Chokshi (@smc90) The writer-showrunner is a relatively new phenomenon in TV, as opposed to film, which is still a director-driven enterprise. But what does it mean, as both a creative and a leader, to “showrun” something, whether a TV show… or a startup? Turns out, there are a lot of parallels with the rise of the showrunner and the rise of founder-CEOs, all working (or partnering) within legacy systems. But in the day to day details, really “owning” and showunning something — while also having others participate in it and help bring it to life — involves doing the work, both inside and out. This special, almost-crossover episode of the a16z Podcast features Billions co-showrunner Brian Koppelman — who also co-wrote movies such as Rounders and Ocean’s 13 with his longtime creative partner David Levien — in conversation with Marc Andreessen (and Sonal Chokshi). The discussion covers everything from managing up — when it comes to executives or investors sharing their “notes” aka “feedback” on your work — to managing down, with one’s team; to managing one’s partners (or co-founders)… and especially managing yourself. How to tame those irrational emotions, that ego? Ultimately, though, it’s all about unlocking creativity, whether in writing, coding, or other art forms. Because something surprising happened: Instead of TV going the way of music à la Napster with the advent of the internet, we’re seeing the exact opposite — a new era of “visual literature”, a “Golden Age” of television and art. Are artists apprenticing from other artists virtually, learning and figuring out the craft (with some help from the internet, mobile, TV)? And if we really are seeing “the creative explosion of all time”, what does it take to explode our own creativity in our work, to better run the shows of our lives? All this and more in this episode of the a16z Podcast… as well as some Billions behind-the-scenes (and light spoilers, alerted within!) towards the end.

When people talk about trends in education technology, they often focus on how to disrupt higher education in the U.S., whether it's about breaking free of the "signaling" factor of elite educations or how to shift education out of its "cottage industry" mindset to achieve greater scale. However, in China, the transformation of education is already well underway, with a fast-growing ecosystem built around lifelong learning. In fact, one of the largest demographic groups paying for education in China is actually not college students -- it's college graduates, aged 26 through 35.In this episode -- which originally aired as a video on our YouTube channel -- a16z general partner Connie Chan talks with operating partner Frank Chen about the lifelong learning ecosystem in China; what it means for startups there; and lessons for entrepreneurs everywhere... or will these techniques even work outside of China?

with George Church (@geochurch) and Jorge Conde (@JorgeCondeBio) Renowned scientist George Church is known for his groundbreaking work and methods used for the first genome sequence, and for his work in genome editing, writing & recoding -- in fact, Church’s innovations have become an essential building block for most of the DNA sequencing methods and companies we see today. In this conversation, a16z bio general partner Jorge Conde -- who also founded a company with Church out of the George Church Lab -- take us on a wild journey into the scientist’s mind and work, starting with what the leading pioneer in the space makes of where we are today with CRISPR (especially given recent news about CRISPR babies in China), to the broader implications of all of this on a cultural level, and finally to what it really takes to go from science fiction, to lab, to reality.

with Peter Ludwig, Qasar Younis (@qasar), and Sonal Chokshi (@smc90) When people talk about autonomous vehicles, we hear everything from "we're much closer than you think" to "we're much further than you think". So where are we, really, in the widespread reality of autonomous vehicles today? It depends, of course, on how you define autonomy -- which is where a handy recap and update of the SAE (Society of Automotive Engineers) levels of autonomy comes in. But still, given everything out there from self-driving shuttles to Teslas, it's really hard to tell just where we are and where the nuances of, say, Level 2-plus vs. Level 3 might come in. This episode of the a16z Podcast takes a quick pulse on where we are in the state of autonomy in 2019 when it comes to autonomous cars, shuttles, robots -- basically any "autonomous" and/or "self-driving" vehicle out there -- as well as the analogy of mobile for understanding the space: where it works, where it breaks down. But did even the mobile industry itself really have a clear iPhone "moment"? When did mobile devices that seemed so limited -- or seemed like just "toys" -- suddenly (or not so suddenly) go to an apps layer that we use every single day? How do we build "the rails" and "the trains" at the same time in this case? And perhaps most importantly, where will the spoils of this new wave of innovation go -- to Silicon Valley or Detroit? Or outside the U.S.? Who are the players? How do regulatory -- and quite frankly, nationalistic -- concerns come into play here? And finally, how does one balance the desire to embrace innovation in an open and fast, yet still very thoughtful and safe way? The answers, according to Applied Intuition co-founder and CEO Qasar Younis and CTO Peter Ludwig (in conversation with Sonal Chokshi), have to do with commodities and capitalism, with science and science fiction, with simulation and software as infrastructure, and more... And really, how we define autonomy now, and in the future.

Bobby Kotick is the CEO of Activision Blizzard (a merger he engineered); it's one of only two video gaming companies in the Fortune 500, and the largest game network in the world. The company is responsible for some of the most iconic entertainment franchises, including Call of Duty, Candy Crush, Overwatch, and World of Warcraft -- as well as its own professional esports league. So in this episode of the a16z Podcast, Marc Andreessen interviews Kotick on everything from the evolution of video games in the 1980s to gaming trends more broadly. What changes as gaming goes from "just for nerds" to "just for kids" and spreads more broadly into entertainment and cultural phenomena (esports, Fortnite, Pokemon Go, etc.)... both online and offline? The conversation originally took place at our annual innovation a16z Summit in November 2018 -- which features a16z speakers and invited experts from various organizations discussing innovation at companies small and large. You can also see other podcasts and videos from this event here: https://a16z.com/tag/summit-2018/

with Ryan Caldbeck (@ryan_caldbeck), Jeff Jordan (@jeff_jordan), and Sonal Chokshi (@smc90) It's clear that all kinds of commerce companies and consumer products have been disrupted -- or enabled -- by tech. Yet for certain categories, like consumer packaged goods (CPG), it seems like tech hasn't changed things very much. How is the rise of so-called "micro-brands" (or emerging brands) playing out here? And, how is it possible that "real" -- different -- innovation isn't really happening in the CPG industry, despite the tremendous legacy of brand, talent, and more in the space? How are CPG companies tackling grocery, which represents the perfect end-capsule and case study of challenges -- and opportunities -- in going from offline to online, from online to offline, and more? As for grocery itself, stores themselves (in the U.S. at least) haven't changed very much due to tech, either... is it a last-mile delivery thing; could we also possibly move to distribution-only centers in the future? Finally, while the holy grail of performance marketing and personalization remains elusive for the industry -- let’s face it, most brands are still guessing in the dark (and forget trying to customize offerings!) -- even going direct-to-consumer (DTC) hasn't been shining as much of a light here as one might expect. Or so argue the guests in this episode of the a16z Podcast, featuring Ryan Caldbeck of CircleUp, along with a16z general general partner Jeff Jordan, in conversation with Sonal Chokshi. Cuz this episode is all about CPG, DTC; micro-brands, yah you know, all kinds of commerce.

with Kate Darling (@grok_) and Hanne Tidnam (@omnivorousread) We already know that we have an innate tendency to anthropomorphize robots. But beyond just projecting human qualities onto them, as we begin to share more and more spaces, social and private, what kind of relationships will we develop with them? And how will those relationships in turn change us? In this Valentine’s Day special, Kate Darling, Researcher at MIT Labs, talks with a16z's Hanne Tidnam all about our emotional relations with robots. From our lighter sides -- affection, love, empathy, and support -- to our darker sides, what will these new kinds of relationships enhance or de-sensitize in us? Why does it matter that we develop these often intense attachments to these machines that range from tool to companion -- and what do these relationships teach us about ourselves, our tendencies and our behaviors? What kinds of models from the past can we look towards to help us navigate the ethics and accountability that come along with these increasingly sophisticated relationships with robots?

with Chris Burniske (@cburniske), Joel Monegro (@jmonegro), Denis Nazarov (@Iiterature), and Jesse Walden (@jessewldn) When designing cryptonetworks -- really, emerging economies -- how do we avoid some of the monetary and fiscal policy failings of "real-world" economies? Like not separating currency and capital, which accelerated and spread economic growth through the former... but also concentrated the latter into the hands of a few? Yet how can we empower users to access capital while also managing risk? If the promise of cryptonetworks is to better align incentives and value capture, then we can't make the same mistakes as we did in traditional economies. We also have the chance to do novel things not possible in the physical world, through software. So this episode of the a16z Podcast -- featuring voices from Placeholder VC and a16z Crypto -- goes deep into the nuances and mechanisms of cryptonetworks, tokens, and decentralized applications at every layer of the "stack". Chris Burniske (who has written a lot about financial modeling-influenced frameworks for analyzing crypto) and Joel Monegro (who has written about "fat protocols", and once managed the Digital Economy Department at the Ministry of Industry and Commerce of the Dominican Republic) of Placeholder VC discuss and debate all of the above -- and more! -- with a16z crypto's Denis Nazarov and Jesse Walden (co-founders of Mediachain, which was acquired by Spotify). Throughout the history of information technology, we've gone from hardware to software, and software to data. So what's next, what's the layer above data? The answer is governance -- which gives more people a way to participate in decision making around a given network -- but the answer for how to implement the best governance isn't so clear.

with Phil Daian (@phildaian) and Ali Yahya (@ali01) Whether in corporations, boardrooms, or political elections, voting is something we see in all kinds of social systems... including blockchains. It's the natural human tendency for how to organize decisions, and in distributed systems without centralized middlemen, it's the only clear Schelling point we can come up with. But too many people design voting mechanisms in distributed systems in isolation -- sometimes naively "porting over" assumptions from the real world or from simple cryptoeconomic models without thinking through the economic adversaries present in a larger, more rational (vs. "honest") game-theoretic system. So how are blockchain systems different from real-world paper and electronic voting systems? How can such systems be gamed, and what are the implications for cryptoeconomic security... as well as the governance of distributed organizations? This hallway-style episode of the a16z Podcast covers all this and more. Recorded as part of our NYC roadtrip, it features Cornell Tech PhD student and software engineer Phil Daian, who researches applied cryptography and smart contracts -- and who also wrote about "On-chain Vote Buying and the Rise of Dark DAOs" in 2018 (with Tyler Kell, Ian Miers, and his advisor Ari Juels). Daian is joined by a16z crypto partner Ali Yahya (previously a software engineer and machine learning researcher at GoogleX and Google Brain), who also recently presented on crypto as the evolution -- and future -- of trust. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Jyoti Bansal (@jyotibansalsf), Peter Levine, Satish Talluri (@satishtalluri), and Sonal Chokshi (@smc90) One of the toughest challenges for founders -- and especially technical founders who are used to focusing so much on product features over sales -- is striking "product-market fit". The concept can be defined many ways, but the simple definition shared in this episode is: it's when you understand the business value of your product. And that comes down to users, which is where the concept of "product-market-sales fit" comes in, observes Jyoti Bansal, founding CEO of AppDynamics (which was acquired by Cisco for $3.7B the night before it was to IPO). Bansal shares this and other key milestones and frameworks for company building in conversation with a16z general partner Peter Levine; enterprise deal team partner Satish Talluri (who was a director of product and growth operations there); and Sonal Chokshi. So in that shift from product-market fit to product-market-SALES fit, how much should you optimize your go-to-market for product... and even the other way around? What does this mean for product design and product management? When should companies offer services? As for pricing, how do you know you're not leaving value on the table? Again, it comes down to product-market fit: If your business case is strong, you will not be leaving money on the table, argues Bansal in this special podcast series on founder stories and lessons learned in enterprise go-to-market.

with Mark Leslie (@mleslie45) and Peter Levine What does it actually take to win at enterprise sales? In this episode, Mark Leslie, former CEO and chairman and founding team member of Veritas Software, and a lecturer at the Stanford Graduate School of Business, and a16z general partner Peter Levine -- who worked together at Veritas -- share stories from the field all about sales and entrepreneurship in the enterprise. The wide-ranging conversation covers everything from what makes a good salesperson; to how to actually close that deal; to how to build a company that best incentivizes your sales reps. This episode is based on a conversation that originally took place at an event held at Andreessen Horowitz for veterans participating in the BreakLine education and hiring program for shifting veterans into careers in the tech industry.

with Peter Levine, Bob Tinker, and Hanne Tidnam (@omnivorousread) For consumer companies, often when the holy grail of product-market fit is achieved, the company takes off: magic happens, growth unlocks. Enterprise B2B companies face a different challenge. Sometimes, despite achieving product-market fit (and knowing when you've achieved it) and winning your first cohorts of renewing customers -- growth remains a challenge. Industry analyst maps are riddled with the logos of enterprise B2B companies who built outstanding products, won outstanding initial sets of customers... and then ultimately failed to scale. In this episode of the a16z Podcast, Bob Tinker, author of the book Survival to Thrival and founding CEO of MobileIron, and a16z general partner Peter Levine, talk with Hanne Tidnam all about how to find the right go-to-market fit for the enterprise startup. How do founders avoid that moment of reckoning after product-market fit, but before growth? When should an enterprise startup accelerate sales investments?  -- the "Goldilocks problem" (not too early, not too late!) -- and pick the right sales team and go-to-market model for their product and their customers? And if you're stuck in that moment where growth stalls, what are the right tools to get out of it? What are the important metrics to know both where you are, and when you're out of the woods?

Veterinary oncology can inform human oncology, and vice versa -- providing a better model for looking at drug performance, interrelationships, and more. Especially when you add in data (there's no "doggy HIPAA!") and networks to get a "living laboratory at scale". Or so argues Amy Abernethy (Chief Medical and Chief Scientific Officer at Flatiron Health and advisor to One Health), who was recently named the new Principal Deputy Commissioner of the FDA, pending ethics clearance; and Christina Lopes, CEO and co-founder of One Health; in conversation with a16z bio general partner Jorge Conde. Dogs -- as a species, as pets, as companions, as family members -- evolved alongside humans, so are actually more similar to us... not just genetically and in terms of the biologic pathways that may cause cancer, but also in exposure to similar environmental factors as well. But what does this all mean when it comes to thinking about real-world evidence in science, human clinical trials, and more broadly, building a bio company? How can product designers -- of all kinds -- backwards-architect their product roadmap for data network effects? And how can bio founders keep both a big-picture roadmap in mind while also focusing on specific milestones, and while working across unconnected disciplines as well? We cover all this and more in this special episode of the a16z Podcast, recorded during the recent J.P.M. healthcare conference in San Francisco. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Joel de la Garza, Jonathan Lusthaus, and Hanne Tidnam (@omnivorousread) The idea of the cybercriminal as lone wolf or hobby hacker is no longer much of a reality. Instead, the business of cybercrime looks a lot more just like that -- a large, global technology business, with many of the associated structures, challenges, and even casts of characters that legitimate businesses have. In this conversation, a16z's Joel de la Garza, a16z operating partner for information security (formerly CSO of Box and head Citigroup's Cyber Intelligence Center), and Hanne Tidnam, discuss with Jonathan Lusthaus -- Director of the Human Cybercriminal Project at the University of Oxford -- the evolution of the industry of cybercrime from single perpetrator into a sprawling and sophisticated international industry as discussed in his new book, Industry of Anonymity: Inside the Business of Cybercrime. A dive into the sociological, operational, and tactical realities of this murky underworld, Lusthaus and de la Garza discuss what the current industry has evolved into -- who the players are, what they are motivated by, and specialize in -- as well as how basic ideas like trust and anonymity function in a world where no one wants to get caught. How do criminal nicknames function as brand? Which countries tend to specialize in what kinds of crime, and why? And most of all, what changes when you begin to think of the business of cybercrime as an industry?

with Benedict Evans (@benedictevans) and Steven Sinofsky (@stevesi) Every year, the Consumer Electronics Show (CES) puts the latest and greatest developments in consumer technology on display in Vegas. But beyond the excitement and the hype, what's really here -- or not here -- to stay? Will televisions roll up into tiny boxes? Will Alexa find her way into electric carving knives? Which of these new gadgets will stand the test of time?  In this episode of the a16z podcast, Benedict Evans and Steven Sinofsky share their take not only on what this year’s show had to offer, but the broader trends at play. From the evolution of the smart home and voice interfaces to the cycle of bundling and unbundling and the future of TV and entertainment, the discussion is a pulse check on where we're at. The content provided here is for informational purposes only, and does not constitute an offer or solicitation to purchase any investment solution or a recommendation to buy or sell a security; nor it is to be taken as legal, business, investment, or tax advice. In fact, none of the information in this or other content on a16z.com should be relied on in any manner as advice. Please see https://a16z.com/disclosures/ for further information. This podcast may contain forward-looking statements relating to the objectives, opportunities, and the future performance of the U.S. market generally as well as specific publicly traded companies. Forward-looking statements may be identified by the use of such words as; “believe,” “expect,” “anticipate,” “should,” “planned,” “estimated,” “potential” and other similar terms. Examples of forward-looking statements include, but are not limited to, estimates with respect to financial condition, results of operations, and success or lack of success of any particular investment strategy. All are subject to various factors, including, but not limited to general and local economic conditions, changing levels of competition within certain industries and markets, changes in interest rates, changes in legislation or regulation, and other economic, competitive, governmental, regulatory and technological factors affecting a portfolio’s operations that could cause actual results to differ materially from projected results. Such statements are forward-looking in nature and involve a number of known and unknown risks, uncertainties and other factors, and accordingly, actual results may differ materially from those reflected or contemplated in such forward-looking statements. Prospective investors are cautioned not to place undue reliance on any forward-looking statements or examples. None of AH Capital Management, L.L.C. or any of its affiliates, principals, employees nor any other individual or entity assumes any obligation to update any forward-looking statements as a result of new information, subsequent events or any other circumstances. All statements made herein speak only as of the date that they were made.

with Susannah Fox (@susannahfox), Anil Sethi (@anilsethiusa / @ciitizencorp), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90) The problem of "dark data" in healthcare isn't just a feel-good empowerment thing, but a structural issue that leads to miscommunication and extra friction, different players in the entire healthcare system not being able to collaborate with each other, and just major missed opportunities all round. And yes, it also leads to lack of empowerment for patients, not to mention doctors too (who often have less than 30 minutes on site to do their jobs). But we already know all that. What's not clear is WHY and HOW is this the case, when the very point of HIPAA -- the Health Insurance Portability and Accountability Act (of 1996!) -- is to make data portable, not private. That is, IF patients know to ask for it... and can easily get it. So what if we could have a sort of permissioned "permissionless innovation" for healthcare data, not only bringing all that dark data to light, but more importantly -- borrowing from the history of internet innovation -- letting all sorts of expected and unexpected uses be built on top as a result? What happens when data and entities can talk to each other (à la APIs) through patients at the center of the circle of data? From the Dr. Google problem (or opportunity!) to clinical trials and even the opioid crisis, we -- Susannah Fox (former CTO of the U.S. Department of Health and Human Services); Anil Sethi (CEO and founder of Ciitizen); and a16z bio general partner Vijay Pande; in conversation with Sonal Chokshi -- explore all this and more in this episode of the a16z Podcast. Let there be light!

with Vas Narasimhan (@vasnarasimhan), Jorge Conde (@jorgecondebio), Vijay Pande (@vijaypande), and Sonal Chokshi (@smc90)On average, only 1 out of 20 medicines works when we actually bring them into the human body, and these rates of success haven't moved much in the pharma industry overall in the past 15 years, despite much scientific progress. Because if you really think about it, it's incredible that we find any human medicine that works at all, given that human beings are the product of billions of years of evolution, and represent an incredibly complex system we do not fully understand. Yet the business of the pharma industry -- and Novartis in particular, which covers everything from generics to innovative medicines -- is not that different from other large enterprises when it comes to managing R&D and pipelines of ideas, talent, and sales.So in this conversation, a16z bio general partners Jorge Conde and Vijay Pande with Sonal Chokshi interview Vas Narasimhan, CEO of Novartis. How does the world's largest producer of medicines in terms of volume -- 70. billion. doses. a. year. -- balance the science and the business of innovation? How does an enterprise at such vast scale make decisions about what to build vs. buy, especially given the fast pace of science today? How does it balance attitudes between "not invented here" and "not invented yet"?Narasimhan also takes us through the latest trends in therapeutics, such as cell and gene therapies (like CAR-T for cancer and more); RNA-based modalities; and others -- a sweeping tour from small molecules to large molecules to proteins and other modalities for making medicines. But where does tech come into all this, and where are we, really, on science becoming engineering? Why do both big companies and bio startups now need to get market value signals (not just approvals!) from payers earlier in the process of making therapeutics? And beyond all that, how could clinical trials be reinvented? Finally, what should all scientific (and all technical) leaders know when it comes to leadership? All this and more in this episode of the a16z Podcast, recorded recently on the road while at the J.P.M. health conference in San Francisco. image: Global Panorama/ Flickr

with James J. Collins, Vijay Pande (@vijaypande), and Hanne Tidnam (@omnivorousread) The idea of 'designing biology' -- once science fiction -- has over the last 20 years become just... science. In this episode, a16z bio general partner Vijay Pande with Hanne Tidnam talk all about the field of synthetic biology with James J. Collins, professor of bioengineering at MIT. Collins, whose work in synthetic biology and systems biology pioneered the field, has also launched a number of companies and received numerous awards and honors (including a MacArthur "Genius" Award, an NIH Director's Pioneer Award, and Sanofi-Institut Pasteur Award). This wide-ranging conversation about the birth of synthetic biology covers everything from the founding story of the discipline to what "engineering and designing" biology really looks like in action -- when instead of engineering electrons, you are engineering toggle switches for genes -- to the disciplinary differences (and synergies) between how biologists and engineers see the world. What are the engineering and design principles, techniques, approaches that work best when applied to science? How does building a company in this new space look different, in terms of platforms and products? And how is this new field changing education in science, all the way down to kits that allow you to play with the machinery of a cell... at home... and even in middle school?

The past and future of marketplace startups -- where are we? Ever since eBay popularized an internet meeting place for buyers and sellers of, well, just about everything, we’ve been waiting for 100 other at-scale marketplaces for everything else, including services. So in this hallway-style episode of the a16z Podcast (originally recorded as a video) Li Jin -- co-author with Andrew Chen of this post -- chats with a16z Deal & Research team operating partner about why there aren’t 100 thriving marketplaces for services yet... And what’s changing to make this next wave of marketplace startups super exciting. The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation. This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/. Charts and graphs provided within are for informational purposes solely and should not be relied upon when making any investment decision. Past performance is not indicative of future results. The content speaks only as of the date indicated. Any projections, estimates, forecasts, targets, prospects, and/or opinions expressed in these materials are subject to change without notice and may differ or be contrary to opinions expressed by others. Please see https://a16z.com/disclosures for additional important information.

with Marc Andreessen (@pmarca), Ben Horowitz (@bhorowitz), and Tyler Cowen (@tylercowen) This episode of the a16z Podcast features the rare combination of a16z co-founders Marc Andreessen and Ben Horowitz in conversation, together, with economist Tyler Cowen (chair of economics at George Mason University and chairman and general director of the Mercatus Center there, and host of his own podcast.) The conversation originally took place at our most recent annual innovation Summit -- which features a16z speakers and invited experts from various organizations discussing innovation at companies large and small, as well as tech trends spanning bio, consumer, crypto, fintech, and more. This discussion covers Ben and Marc's marriage, er, partnership; the evolution of VC and "talent as a network"; and where are we right now on industries being affected by tech (such as retail) and tech trends (such as VR/AR and wearables) -- and where are we going next? Finally, is software eating culture... or is it the other way around?

In his book (and podcast), Brian McCullough chronicles the history and evolution of the internet -- from college kids in a basement and the dot-com boom, to the applications built on top of it and the entrepreneurs behind them. General partner Chris Dixon chats with McCullough about How the Internet Happened -- and more broadly, about how tech adoption and innovation happens. The content provided here is for informational purposes only, and does not constitute an offer or solicitation to purchase any investment solution or a recommendation to buy or sell a security; nor it is to be taken as legal, business, investment, or tax advice. In fact, none of the information in this or other content on a16zcrypto.com should be relied on in any manner as advice. Please see https://a16zcrypto.com/disclosures/ for further information.