In this episode of The School of Greatness, Dr. David Perlmutter discusses the critical link between metabolism and brain health, particularly regarding Alzheimer's disease. Highlighting that metabolic dysfunction may precede cognitive decline by decades, he stresses the importance of dietary choices and mitochondrial function. The conversation explores how factors like fructose consumption and obesity pose threats to brain health and challenges traditional pharmaceutical approaches, advocating for lifestyle changes to enhance metabolic health. With insights from personal experience, Dr. Perlmutter contends that Alzheimer's should be viewed primarily as a metabolic issue, emphasizing preventative strategies and the potential reversibility of cognitive decline through metabolic intervention.