Dr. Shanna Swan: How to Safeguard Your Hormone Health & Fertility AI transcript and summary - episode of podcast Huberman Lab

Go to PodExtra AI's episode page (Dr. Shanna Swan: How to Safeguard Your Hormone Health & Fertility) to play and view complete AI-processed content: summary, mindmap, topics, takeaways, transcript, keywords and highlights.

Go to PodExtra AI's podcast page (Huberman Lab) to view the AI-processed content of all episodes of this podcast.

Huberman Lab episodes list: view full AI transcripts and summaries of this podcast on the blog

Episode: Dr. Shanna Swan: How to Safeguard Your Hormone Health & Fertility

Author: Scicomm Media
Duration: 02:18:02

Episode Shownotes

In this episode, my guest is Dr. Shanna Swan, Ph.D., professor of environmental medicine and reproductive health at the Mount Sinai School of Medicine. Dr. Swan is the world’s leading expert on the harmful impact of chemicals in our food, water, cosmetics, and various household and consumer products on our

hormones, and the consequences for fertility and overall reproductive health. She explains how exposure to phthalates and other endocrine disruptors adversely impacts fetal development, puberty, and the adult brain and body. We discuss the global decline in human fertility due to disruptive environmental toxins, such as pesticides, and certain foods and beverages we consume. We discuss practical strategies to minimize exposure to harmful chemicals, such as phthalates, bisphenol A (BPA), BPS, and PFAS. This includes reducing disposable plastic use, making healthier food preparation, consumption, and storage choices, and selecting personal and household products that don’t contain harmful toxins. This episode allows you to assess your risk of exposure to endocrine disruptors accurately and empowers you to take control of your hormone health and fertility. Access the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman ROKA: https://roka.com/huberman BetterHelp: https://betterhelp.com/huberman Function: https://functionhealth.com/huberman Timestamps 00:00:00 Dr. Shanna Swan 00:02:58 Sponsors: LMNT, ROKA & BetterHelp 00:06:49 Environmental Chemicals, Fertility, Hormones, Phthalates 00:13:30 Phthalate Syndrome, Animal Data, Male Offspring 00:19:11 Phthalate Syndrome in Humans, Pregnancy & Babies 00:27:30 Hyenas; Phthalate Syndrome in Males 00:32:49 Sponsor: AG1 00:34:22 Polycystic Ovary Syndrome (PCOS), Mothers & Female Offspring 00:39:03 Anogenital Distance & Sperm Count 00:45:03 Sperm Count & Fertility 00:49:24 Sponsor: Function 00:51:11 Sperm Count Decline 00:58:19 Sperm Quality & Pesticides 01:04:12 Atrazine, Amphibians, Sexual Dimorphism, Behavior 01:09:00 Preschoolers, Phthalate Exposure, Sexually Dimorphic Behaviors 01:14:08 Tools: Lowering Exposure to Endocrine Disruptors, Fertility 01:24:52 Tools: BPA, BPS, BPF & Can Linings; Drinkware; Plastics & Microwave 01:30:07 Tools: Buying Organic; Skin Products, Fragrance; Sunscreens, Consumer Guides 01:32:58 Funding 01:34:31 Tools: Distilling Water, Shoes, Clothing, Food Sourcing; Building Materials 01:40:12 Europe vs. US Chemical Safety, REACH Program 01:46:20 Tool: Pregnancy & Fetal Health 01:49:23 Plastics & Environmental Concern; Fertility 01:55:26 Sperm Quality, Fertility, Cell Phone, Temperature 01:58:04 Other Animals & Fertility Decline, Ecosystems 02:01:58 Advancing Technologies, Fertility, Offspring & Adverse Effects 02:06:02 Tool: Consumer Guides, Personal & Household Products 02:09:39 Tool: Receipts; Thyroid System; Non-Stick Pans 02:15:18 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, Sponsors, YouTube Feedback, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures

Summary

In this episode, Dr. Shanna Swan discusses the adverse effects of environmental toxins, particularly phthalates, on hormone health and fertility. She explains how these endocrine disruptors contribute to a global decline in fertility rates, testosterone levels, and increasing reproductive health issues. Practical strategies for minimizing exposure to harmful chemicals are provided, emphasizing informed choices in food and product selections to safeguard reproductive health. Dr. Swan's insights highlight the importance of recognizing the risks posed by these chemicals and encourage proactive measures to enhance overall wellbeing.

Go to PodExtra AI's episode page (Dr. Shanna Swan: How to Safeguard Your Hormone Health & Fertility) to play and view complete AI-processed content: summary, mindmap, topics, takeaways, transcript, keywords and highlights.

Full Transcript

00:00:00 Speaker_00
Welcome to the Huberman Lab Podcast, where we discuss science and science-based tools for everyday life. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. My guest today is Dr. Shana Swan.

00:00:18 Speaker_00
Dr. Shana Swan is a professor of environmental medicine and public health at the Mount Sinai School of Medicine. She is a world expert in how exposure to various toxins and compounds in the food and environment impact our reproductive health.

00:00:33 Speaker_00
She focuses on how these compounds in our air, in our food supply, in our water supply, in cosmetics, even in household items, impact the developing fetus, children and adults at the level of their reproductive biology.

00:00:48 Speaker_00
So things like testosterone and estrogen and the pathways within the brain and body that are impacted by testosterone and estrogen.

00:00:55 Speaker_00
but also how all of those things in our environment and that we put into our body impact our health on a daily basis and our long-term health.

00:01:03 Speaker_00
So during today's discussion, you will learn why fertility rates are indeed dramatically dropping from year to year and have been for quite some time now.

00:01:13 Speaker_00
You'll also learn why testosterone levels are dropping, why sperm counts are dropping, why things like polycystic ovarian syndrome are increasing in women, and what we can do about it.

00:01:24 Speaker_00
In fact, during much of today's discussion, Dr. Swan emphasizes the things that you can do every single day. And that in fact, turned out to be very simple.

00:01:32 Speaker_00
They involve certain things to do and certain things to avoid in order to limit your exposure to these environmental toxins and their impact.

00:01:41 Speaker_00
So by the end of today's episode, you will be highly informed by the world expert on endocrine disruptors and environmental toxins.

00:01:48 Speaker_00
and you will also be highly informed in terms of how you can have agency, how you can take control of your health in relation to these various compounds.

00:01:57 Speaker_00
Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford.

00:02:03 Speaker_00
It is, however, part of my desire and effort to bring zero cost to consumer information about science and science-related tools to the general public. In keeping with that theme, I'd like to thank the sponsors of today's podcast.

00:02:15 Speaker_00
Our first sponsor is Element. Element is an electrolyte drink that has everything you need and nothing you don't. That means the electrolytes, sodium, magnesium, and potassium in the correct ratios, but no sugar.

00:02:26 Speaker_00
We should all know that proper hydration is critical for optimal brain and body function. In fact, even a slight degree of dehydration can diminish your cognitive and physical performance to a considerable degree.

00:02:36 Speaker_00
It's also important that you're not just hydrated, but that you get adequate amounts of electrolytes in the right ratios.

00:02:42 Speaker_00
Drinking a packet of Element dissolved in water makes it very easy to ensure that you're getting adequate amounts of hydration and electrolytes.

00:02:49 Speaker_00
To make sure that I'm getting proper amounts of both, I dissolve one packet of Element in about 16 to 32 ounces of water when I wake up in the morning, and I drink that basically first thing in the morning.

00:02:59 Speaker_00
I'll also drink a packet of Element dissolved in water during any kind of physical exercise that I'm doing, especially on hot days when I'm sweating a lot and losing water and electrolytes.

00:03:07 Speaker_00
There are a bunch of different great tasting flavors of Element. And now that we're entering the winter months, at least here in the Northern Hemisphere, Element has their chocolate medley flavors back in stock.

00:03:17 Speaker_00
I really like these chocolate flavors, especially the chocolate mint. when mixed into hot water. And of course, despite being a bit colder outside, hydration is still critically important.

00:03:25 Speaker_00
In fact, a lot of people don't realize this, but even when it's cold out, it's easy to get dehydrated. And that's because the air is dry.

00:03:32 Speaker_00
And so even though you don't notice the accumulation of sweat on your skin, you can still be losing a lot of water and electrolytes.

00:03:38 Speaker_00
If you'd like to try Element, you can go to drinkelement.com slash Huberman to claim an Element sample pack with the purchase of any Element drink mix.

00:03:46 Speaker_00
Again, that's drinkelement spelled L-M-N-T, so it's drinkelement.com slash Huberman to claim a free sample pack. Today's episode is also brought to us by Roka. Roka makes eyeglasses and sunglasses that are of the absolute highest quality.

00:04:01 Speaker_00
I've been wearing Roka readers and sunglasses for years now, and I love them. They're lightweight, they have superb optics, and they have lots of frames to choose from.

00:04:09 Speaker_00
I'm excited to share that Roka and I have teamed up to create a new style of red lens glasses. These red lens glasses are meant to be worn in the evening after the sun goes down.

00:04:18 Speaker_00
They filter out short wavelength light that comes from screens and from LED lights, the sorts of LED lights that are most commonly used as overhead and frankly lamp lighting nowadays.

00:04:27 Speaker_00
And I want to emphasize, Roka Red Lens glasses are not traditional blue blockers. They're not designed to be worn during the day and to filter out blue light from screen light.

00:04:37 Speaker_00
They're designed to prevent the full range of wavelengths that suppress melatonin secretion at night and that can alter your sleep. So by wearing Roka Red Lens glasses, they help you calm down and they improve your transition to sleep.

00:04:49 Speaker_00
Most nights I stay up until about 10 p.m. or even midnight and I wake up between 5 and 7 a.m. depending on when I went to sleep.

00:04:56 Speaker_00
Now I put my Roka Red Lens glasses on as soon as it gets dark outside, and I've noticed a much easier transition to sleep, which makes sense based on everything we know about how filtering out short wavelengths of light can allow your brain to function correctly.

00:05:09 Speaker_00
Roka Red Lens glasses also look cool, frankly. You can wear them out to dinner or to concerts or out with friends. So it turns out it is indeed possible to support your biology, to be scientific about it, and to remain social after all.

00:05:21 Speaker_00
If you'd like to try Roka, go to Roka.com, that's R-O-K-A dot com and enter the code Huberman to save 20% off your first order. Again, that's R-O-K-A dot com and enter the code Huberman at checkout. Today's episode is also brought to us by BetterHelp.

00:05:37 Speaker_00
BetterHelp offers professional therapy with a licensed therapist carried out entirely online. Now, I've been doing weekly therapy for well over 30 years.

00:05:45 Speaker_00
In fact, I consider doing regular therapy just as important as getting regular exercise, including cardiovascular exercise and resistance training exercise, which of course I also do every week.

00:05:56 Speaker_00
Now, there are essentially three things that great therapy provides. First, it provides a good rapport with somebody that you can really trust and talk to about any and all issues that concern you.

00:06:05 Speaker_00
Second of all, great therapy provides support in the form of emotional support, but also directed guidance, the do's and the not to do's. And third, expert therapy can help you arrive at useful insights that you would not have arrived at otherwise.

00:06:18 Speaker_00
With BetterHelp, they make it very easy to find an expert therapist with whom you can really resonate with and provide you with these three benefits that I described.

00:06:25 Speaker_00
Also, because BetterHelp is carried out entirely online, it's very time efficient and easy to fit into a busy schedule with no commuting to a therapist's office or sitting in a waiting room or looking for a parking spot.

00:06:36 Speaker_00
So if you'd like to try BetterHelp, go to betterhelp.com slash Huberman to get 10% off your first month. Again, that's betterhelp.com slash Huberman. And now for my discussion with Dr. Shauna Swan. Dr. Shauna Swan, welcome.

00:06:51 Speaker_01
Dr. Andrew Huberman, thank you.

00:06:55 Speaker_00
I'm super excited for today's conversation. I've followed your work for a number of years. I've seen some of your appearances on other podcasts, and I got to see you speak while we were both in Copenhagen. I was in the audience.

00:07:10 Speaker_00
You didn't know I was there, but incredible stuff that you've been doing as a researcher, as a public educator, as a writer. Let's kick off by just asking the basic question. Are there things in our environment

00:07:25 Speaker_00
including our food that are diminishing our reproductive and overall health? And if so, which are the ones that you think about?

00:07:35 Speaker_00
And perhaps if you could just mention a few of the more salient, maybe even shocking, but salient results that you've observed over the years. Like what was the kind of like, whoa,

00:07:49 Speaker_00
result or results that have really steered your attention in the last couple of decades. And I'll just say what we were talking about before we were on the microphone, which is that you are a skeptic.

00:08:00 Speaker_00
You are not somebody who walks out into the world and looks for things that could be messing up our biology, messing up our health. And yet, you've found some.

00:08:10 Speaker_00
So if you could just share with us what you've observed and what you find really compelling and important for people to know about, we can dive in there.

00:08:16 Speaker_01
That was a lot of questions. I could probably talk for a long time.

00:08:20 Speaker_00
Feel free. I won't speak until you're done.

00:08:22 Speaker_01
No, but I want to break it up. Let's break it up. So I think the first question about was, are there forces, chemicals, agents in the environment that can affect our reproductive health. Yes? Okay, so my answer to that is yes.

00:08:37 Speaker_01
I think there's no question about that. The question comes down to when and in whom and what dose and so on and so forth. But whether there are Let's just say broadly things, yes, of course.

00:08:55 Speaker_01
The category that I focus on are man-made, primarily man-made chemicals, although I do also include the influence of Other factors, factors of choice, for example, sleep, exercise, that kind of thing. We can talk about that.

00:09:16 Speaker_01
But let's just focus here on the chemicals, because I think that's what led me to do a lot of my research and to write the book that I wrote. And so my thesis is that chemicals in the environment

00:09:34 Speaker_01
That's a very broad class, so we'll have to say some chemicals in the environment, at the right time, to the right organism, affect fertility. Okay?

00:09:45 Speaker_01
So, and let me just say fertility is one area that I focused on, but actually this class of chemicals that I'm primarily interested in are those that affect the body's hormones.

00:09:58 Speaker_01
So those are known as hormone-disrupting chemicals or endocrine-disrupting chemicals, hormone-altering chemicals, whatever. You know, there's a lot of names. But that helps you focus on where to look. for the effects.

00:10:13 Speaker_01
Because if it's hormone-altering, you can now have something to really ask. Okay, here's a chemical. Does it affect a hormone? Which hormone? When? How? And then you start—that's almost, you know, laying out an experiment right there, right?

00:10:29 Speaker_01
So focusing in on hormone-disrupting chemicals I think is useful.

00:10:33 Speaker_00
Absolutely. Yeah. And I think much of what we'll talk about today probably centers on the estrogen and testosterone pathways as they relate to masculinization or feminization of the brain and body and sperm and egg quality.

00:10:51 Speaker_01
So I'm a reproductive epidemiologist. I got there in an indirect path. I think probably my work on, oral contraceptives led me there most directly. And oral contraceptives are endocrine-disrupting chemicals.

00:11:10 Speaker_02
That's what they're designed to do.

00:11:12 Speaker_01
That's what they're designed to do, change your body's hormones, your reproductive hormones.

00:11:17 Speaker_01
So it's interesting, you know, way back when, when I worked on the study at Kaiser on oral contraceptives, which was the largest study of its kind in the world, actually, trying to figure out were there adverse effects of oral contraceptives?

00:11:31 Speaker_01
If so, you know, for whom and when and how much and so on. And so that was a very great study.

00:11:36 Speaker_01
And coming forward in time, I studied environmental chemicals, not so much pharmaceuticals, for quite a while when I was at the California Department of Health Services. And then I had an aha moment.

00:12:00 Speaker_01
I was flying to Japan with my friend John Brock, who's a chemist at CDC, wonderful chemist. And we had long flights. We were talking about this and that. And he says, Shauna, you should look at phthalates. And I'm going, why should I look at phthalates?

00:12:18 Speaker_01
I never heard of phthalates. And he said, well, we can now measure them at the CDC, and we see they're in everybody. They're in women of reproductive age, fact one.

00:12:31 Speaker_01
Fact two, colleagues at the NTP have shown something they are calling the phthalate syndrome. And so he explained.

00:12:42 Speaker_00
What is NTP?

00:12:44 Speaker_01
National Toxicology Program, sorry. Thank you. For using alphabet.

00:12:47 Speaker_00
No, it's quite all right.

00:12:49 Speaker_01
National Toxicology Program, a governmental research center. And their job is to look at chemicals and see what is the toxicity. So it could be reproductive, it could be carcinogenicity, it could be neurotoxicity. That's what they do.

00:13:06 Speaker_01
And so they had signaled out these phthalates as being reproductively toxic and specifically to males and specifically when exposure is in utero.

00:13:19 Speaker_00
Pregnant mom is exposed to phthalates and somehow the fetus is disrupted.

00:13:28 Speaker_01
Yes.

00:13:29 Speaker_00
If you don't mind, I'd like to know, is mom ingesting phthalates in the form of food? Is she inhaling phthalates? Are they landing on her skin?

00:13:37 Speaker_00
What are the modes of entry into the body of the mom that, let's just assume it goes through the placental barrier into the fetus and is impacting fetal development?

00:13:47 Speaker_01
So in those experiments, it was through food. But we are exposed in all those ways you mentioned. Every way that something can get into our body, phthalates get in there. But let's come back to that. Let me go to the experiment at NTP.

00:14:01 Speaker_01
So what they did at NTP, National Toxicology Program, they fed mother rats various doses of these various phthalates. And what they found was No changes in the females are not that they found at that time.

00:14:19 Speaker_00
The female offspring?

00:14:21 Speaker_01
Female offspring, sorry. But in the male offspring, they found that the genitals were, I summarize it by saying, incompletely masculinized. So I'll explain what that is.

00:14:33 Speaker_01
So for that, I have to back up and say something you probably know very well, but I'll just explain it. The genital tract initially is a ridge. It's a single ridge. It's the same in males and females. It's not sexually dimorphic at the beginning.

00:14:49 Speaker_01
And then under the influence of testosterone, in a very specific window called the male programming window, in rats it stays, I think, nine to 12 of gestation.

00:15:00 Speaker_00
So a very short window. To orient people, I think rat-mouse gestation is about 21 days or so? Yeah.

00:15:05 Speaker_01
Okay. So for us, it'll be early first trimester. But that comes later. So at that time, if they feed their mother that chemical in her food, then her male offspring are born with changes in his genitals, or more likely to, right?

00:15:28 Speaker_01
And so what they tend to have is a smaller penis, less descent of the testes, more likely to have undescended testicles. There are internal changes that we didn't get into in our human study because we can't

00:15:45 Speaker_01
look there, but the epididymis, there are changes and so on. The whole genital tract is altered. And the most important measure for me, as it turned out, and for humans, and perhaps for animals, is something that the

00:16:01 Speaker_01
scientists, animal scientists had studied for a long time, for actually 90 plus years, but had never been studied in humans. And that is the distance from the anus to the genitals.

00:16:15 Speaker_01
This collection of changes in the male genitals was given the name the phthalate syndrome. Now, you're a physician.

00:16:25 Speaker_01
And you, I challenge you to think of any syndrome, aside from alcohol, you know, feel alcohol syndrome, of course, there's a syndrome, but note what syndrome is attached to a chemical class.

00:16:42 Speaker_00
just for technical purposes. I'm a PhD, not a clinician, but I worked on neural development for many years. And then prior to that, some endocrine stuff. So I'm facile with the general terms.

00:16:56 Speaker_00
One that comes to mind would be, for instance, the thalidomide babies, right? Anti-miscarriage drug that changed limb development. That's a very extreme example. I would say for in human development,

00:17:13 Speaker_00
normal development, what I'm most familiar with are the early organizing effects of androgens that convert to estrogen on external phenotype, which is basically nerd speak for during development, the Y chromosome produces, it leads to the production of a number of genes and eventually proteins through RNA, et cetera, that are

00:17:36 Speaker_00
including testosterone and dihydrotestosterone that in the brain organizes the brain male and causes the growth of the penis or organizes, meaning it sets up the penis to then during puberty, when the penis is exposed to testosterone and estrogen and DHT, it's a bunch of things, not just testosterone, the penis grows.

00:17:57 Speaker_00
So that- And lots of other things. Right, lots of other things, right? So the, the word soup that I just put forward is basically saying that there are a lot of things in development where hormones set up a potential to respond to other hormones later.

00:18:17 Speaker_00
It's not that testosterone grows the penis during development, it does that. but more so it establishes a potential for the penis to grow when exposed to things later during puberty. Do I have that right?

00:18:29 Speaker_01
Right. As far as the name goes, which is the phthalate syndrome, there is thalidomide. It's not usually called the thalidomide syndrome, but it could be. So you're right about that, but it's extremely rare. And there is no environmentally

00:18:45 Speaker_01
you know, a chemical in the environment, as opposed to a pharmaceutical, that is given a syndrome. So this is very, very unique. And so I thought, wow, John's telling me this on the plane, right?

00:18:59 Speaker_00
Something in the environment that is basically having an endocrine and body disruptive effect, at least on par with fetal alcohol syndrome and thalidomide syndrome.

00:19:10 Speaker_01
Right.

00:19:10 Speaker_00
Yeah.

00:19:10 Speaker_01
So when, well, at this point it was only animals, right? Because John was telling me about the NTP study, which was in rats. And so I thought, wow, you know, I like puzzles. So my first question was, is this happening in humans?

00:19:28 Speaker_01
You might ask that, you know, as a natural thing to ask.

00:19:31 Speaker_00
Great question.

00:19:32 Speaker_01
And then I thought, how would we find out? And answering that question, It took me 10 years, okay? And so if you think about, okay, phthalate in the mother changes in the genitals of the offspring, connect them. How do we do that, right?

00:19:56 Speaker_01
So we have to start with phthalates in the mother. So how do we know that? Well, fortunately or not, I had stored a lot of urine from pregnant women from a study that I was doing on sperm count. I just got the women's urine coincidentally, if you will.

00:20:16 Speaker_01
I thought, well, save it. You know, it's not expensive and not hard. Minus 80 degree freezers, doesn't take a lot of room. Put it in there. So I had this urine saved from pregnant women.

00:20:30 Speaker_01
And then I knew from John that we could look in the urine for phthalate metabolites. So these are products that the body forms when they're exposed to phthalates, and you can measure them in urine.

00:20:45 Speaker_01
So I thought, okay, I could get that urine, I could look at the phthalate metabolites, and then I'd know what the mother was exposed to. And based on the animal data, we have good evidence that it actually makes its way to the fetus.

00:21:02 Speaker_01
So then I thought, OK, then maybe there's a change in the babies. So then I had to get the babies.

00:21:09 Speaker_01
So fortunately, I had done this study on pregnant couples, pregnant women and their partners, and I was able to call them and say, would you come in and let us measure your babies' genitals, right?

00:21:25 Speaker_00
How willing were parents to let you do that? They were okay.

00:21:28 Speaker_01
Most of them were okay with that.

00:21:29 Speaker_00
Yeah, yeah.

00:21:30 Speaker_01
Well, they trusted us, you know, they had been in a study with us and, you know, we were... Those babies were still... Young, but not newborn. So this was a while later.

00:21:42 Speaker_01
The babies that we actually got were on average, I think about a month, 12 months old. So not ideal maybe because the rats had been measured at birth. The rat genitals had been... That's what we could do at that time.

00:21:57 Speaker_00
Yeah. The reason I ask is there's always the potential for ongoing phthalate exposure to the newborn. Absolutely.

00:22:03 Speaker_00
But I suppose in either case, you're able to draw some potential link between, or potentially draw a link, I have to be careful with my language there, between phthalate exposure in utero and ex utero. and these external biomarkers.

00:22:18 Speaker_01
I mean, given that the critical window is quite short and quite early, by the way, let me just say, when the rats, they did a lot of work on this critical window. And when the rat moms were exposed before day nine, it did nothing.

00:22:31 Speaker_01
And when they were exposed after day 12, it did nothing. So it was only the exposure during that critical window is very delicate. And it's, by the way, true of the brain as well.

00:22:43 Speaker_01
So teasing out what is the critical window is one of the challenges that we have when we work with these chemicals.

00:22:50 Speaker_01
So I wasn't so much worried about exposure in the delivery room and in their feed in the first year of life because I knew it was unlikely to change these measures. Do other things, maybe, but not these measures.

00:23:06 Speaker_01
So then the question became, kind of what you're asking is, what do we measure? What do we actually measure? And if you think about a newborn rat or mouse, their genitals are pretty small.

00:23:19 Speaker_01
And it's very difficult to know exactly how that corresponds to the human genital system and what you see at birth when you spread a boy's legs, right?

00:23:34 Speaker_01
And so I got a pediatrician in Los Angeles who worked with me on how to make that translation and how to do do this exam. And that took us quite a while because we really wanted to come as close as we could.

00:23:50 Speaker_01
What was clear was that the anus part of it was easy. You go to the center of the anus. So that was easy. Then what's the other landmark? What's the genital landmark? So it turns out there are in males two and in females there are two as well.

00:24:04 Speaker_01
So, but let's just talk about males. So for males, the best place to measure and actually closest to the rat measurement is the place where the tissue changes, where the scrotum inserts. And that, it goes from rugator to smooth.

00:24:23 Speaker_01
And at that point, it's pretty clear, pretty easy to measure. The other measure, and that was the anuscrotal distance. And the other measurement we took was the anal-penile distance. And that was the insertion, the anterior insertion of the penis.

00:24:38 Speaker_00
The part closest to the body.

00:24:40 Speaker_01
Close to the head, yeah.

00:24:42 Speaker_00
Closest to the head.

00:24:42 Speaker_01
Yeah. And that was not so obvious because you don't have a change in tissue there. So where exactly do you put your caliper? We had a lot of discussion about, do you press down? Where exactly do you make that mark?

00:25:03 Speaker_01
And actually, the anal scronal is the measurement with the least variance, because you can measure most precisely. But the anal penile is another measurement. And then you can do something similar in females, and we did that.

00:25:18 Speaker_01
We maybe don't have to go into that now. So we designed this exam, and we did a lot of work to make sure it was repeatable across examiners. And what we finally did was bring the mothers in, bring the babies in.

00:25:37 Speaker_01
got three measurements, and then on every 10th baby, we got an independent examiner to get three measurements. So we could look at within and between examiner variation. You understand this is the first time this had been done this way in humans.

00:25:52 Speaker_01
There was a Mexican study that tried to do this, and I never learned very much about it. And I was excited that they had done this, but I'm not sure how it relates to this. I've just mentioned that out of honesty. Somebody in Mexico did this.

00:26:06 Speaker_01
But to my knowledge, this is the first time it was used as a toxicological measure in humans. Right. So we did that study.

00:26:18 Speaker_01
We related those measurements to what CDC had measured in the urine of our women, collected while they were pregnant, and we found a Sally syndrome.

00:26:31 Speaker_00
Could you explain what the correlation was between phthalate metabolite levels, which is, I believe- Not by number, because I don't remember it anymore, but there was a significant, let's just take the AGD.

00:26:45 Speaker_01
The AGD of mothers who had higher levels of three, the most antiandrogenic phthalates, I'll tell you what those are in a minute, had significantly shorter intergenital distance.

00:26:59 Speaker_01
And then I have to say that, which I haven't said and should have, that intergenital distance is sexually dimorphic. So it tends to be 50 to 100% longer in males than females. That makes sense if you think about what's going in that space.

00:27:17 Speaker_01
There's a lot of real estate in males between the anus and, you know, let's say the penis, penile insertion, much more than in females.

00:27:27 Speaker_01
So it's natural that that will be longer, but that's... I began doing some work looking at other species, and it turns out that that's true in all mammalian species except two. And one is the hyena and one is the elephant.

00:27:45 Speaker_01
So in the hyena, I'm just saying this because you might be amused by it.

00:27:50 Speaker_00
You know about hyenas? I do. I know more about hyena genitalia than I'd like to admit. And I can tell you why after you educate us, but I'll keep my explanation brief, but I'm very familiar with hyena genitalia.

00:28:04 Speaker_01
So I know Stephen Glickman who works with, you might know him too, he works in Berkeley.

00:28:12 Speaker_00
He was my instructor when I was a graduate student at Cal and I used to run in Tilden Park, I suppose I'll tell it now, and there was a colony of wild hyenas, but they were behind chain link.

00:28:25 Speaker_00
It's actually a favorite hike of mine up the Strawberry Canyon Trail. And a good friend of mine, Brian Prendergast, who's now a professor at the University of Chicago, worked on the prairie voles that were also housed at that facility.

00:28:37 Speaker_00
And a fun thing to do was to go see the hyenas with Steve. They're brutally dangerous animals. And Steve has tons of stories about them. We should probably resist our temptation to spiral into that.

00:28:54 Speaker_00
Maybe sometime I'll do a little evening chat podcast where I tell Steve Glickman stories. He's a delightful person.

00:29:03 Speaker_00
Let's just say this, the female hyenas have clitorises larger than some of the male hyena penises, and those females give birth through those clitorises, as we both know.

00:29:13 Speaker_01
So you will not be surprised to know that the female HD is longer than the male.

00:29:19 Speaker_00
Right, because they're heavily androgenized.

00:29:21 Speaker_01
Exactly.

00:29:21 Speaker_00
As I recall by Anderstein-Dyon.

00:29:24 Speaker_01
Actually, I don't know that.

00:29:26 Speaker_00
It became popular during the era of steroids in professional baseball because Anderstein-Dyon was being used pretty frequently in baseball at that time. Anyway, we could go down the spiral of hyenas.

00:29:41 Speaker_01
But also in terms of behavior, the female is the alpha.

00:29:46 Speaker_00
Right. They eat first. Yes. They're physically and hierarchically dominant.

00:29:53 Speaker_01
Right. So it's really interesting, isn't it? That they would have a longer, more masculine intergenital distance. Elephants, we won't go into now, but they're kind of midway in many things.

00:30:06 Speaker_01
So including they're about equal intergenital distance in males and females. Other than that, humans and other species, male intergenital distance is 50 to 100% longer.

00:30:18 Speaker_01
However, so three phthalates, diethylhexyl phthalate, DEHP, dibutyl phthalate, DBP, and butylbenzyl phthalate, BBZP, are the most anti-androgenic testosterone-lowering phthalates.

00:30:38 Speaker_01
And those are the ones that were associated with a shorter androgenal distance in males.

00:30:45 Speaker_00
In human males.

00:30:46 Speaker_01
Human males and animal. So we replicated that animal study in humans. And then, because you know this is how it is in science, I had to do it all again, right? So I started a whole new study, and that study is still going on.

00:31:07 Speaker_01
the children are still being followed. I think we started in 2012. The first paper on endogenital distance came out in 2005, had a pretty big impact.

00:31:21 Speaker_00
So these are studies where you're looking at the endogenital distance in relatively newborn humans, then tracking that distance

00:31:32 Speaker_01
No, that's a different, tracking is another study. Okay, this is just two studies on demonstrating the Thaler syndrome in human males.

00:31:41 Speaker_01
Okay, so the first one I described, the second one, the replication, and the second one is the one that's going on still. So, and what it does to their reproductive function, we don't know, the kids are only 12 years old now.

00:31:54 Speaker_01
So, we would like to know that and we will know that. Okay, but I have another answer for you about that. So we started the second study, and the second study, which is called TIDES, which is the Infant Development Environment Study.

00:32:10 Speaker_01
By the way, these are both in four cities in the United States. And there we did it right. So we got the urine. in the first, you know, early urine, because we knew that could be important. We didn't have that option in the first one.

00:32:26 Speaker_01
Remember, those urine samples were accidental. We got them when we could, right? And we got repeated urines, one in each trimester, to look at the effects in different trimesters.

00:32:37 Speaker_01
And then we examined the babies at birth, which is what the rats... So we came much closer to replicating the rodent study. And we saw it again.

00:32:49 Speaker_00
I'd like to take a quick break and thank our sponsor, AG1. AG1 is an all-in-one vitamin, mineral, probiotic drink with adaptogens. I've been taking AG1 daily since 2012, so I'm delighted that they're sponsoring this podcast.

00:33:03 Speaker_00
The reason I started taking AG1 and the reason I still take AG1 once and often twice a day is because it is the highest quality and most complete foundational nutritional supplement.

00:33:12 Speaker_00
What that means is that AG1 ensures that you're getting all the necessary vitamins, minerals, and other micronutrients to form a strong foundation for your daily health. AG1 also has probiotics and prebiotics that support a healthy gut microbiome.

00:33:26 Speaker_00
Your gut microbiome consists of trillions of microorganisms that line your digestive tract and impact things such as your immune system status, your metabolic health, your hormone health, and much more.

00:33:36 Speaker_00
So I've consistently found that when I take AG1 daily, my digestion is improved, my immune system is more robust, I rarely get sick, and my mood and mental focus are at their best.

00:33:46 Speaker_00
In fact, if I could take just one supplement, that supplement would be AG1. If you'd like to try AG1, you can go to drinkag1.com slash Huberman to claim a special offer.

00:33:56 Speaker_00
For this month only, November 2024, AG1 is giving away one free month supply of omega-3 fatty acids from fish oil in addition to the usual welcome kit of five free travel packs and a year supply of vitamin D3K2 with your order.

00:34:11 Speaker_00
Omega-3 fatty acids are critical for brain health, mood, cognition, and much more. Again, go to drinkag1.com slash Huberman to claim this special offer. More phthalate exposure equates to shorter anal genital distance in males.

00:34:28 Speaker_00
It was approaching the distribution in females. It sounds like the distributions moved more closely together. Yes. Right.

00:34:37 Speaker_01
Although it wasn't the females that moved.

00:34:39 Speaker_00
Sorry. The male distribution- Became more like the female. Became more- Right. Feminized. You could say feminized, but more female-like in its-

00:34:46 Speaker_01
And they, but these boys also had smaller penises, less descent of the testes, smaller scrotums. So they were smaller, you know, everything was in their genital area.

00:34:57 Speaker_00
Are all the secondary sex characteristics of puberty in males, Adam's apple, facial hair growth, thickening of the vocal cords, therefore lowering the voice, et cetera, are those

00:35:08 Speaker_00
all later activating effects of hormones, or are there precursors to those that are present in males? Because in mice, as I recall,

00:35:20 Speaker_00
Like I couldn't tell you, like we call it in the laboratory, people always chuckle at this, but it's like sexing the animals when you, you know, look to determine if it's a male or female.

00:35:31 Speaker_00
When they're really young, you have to like look carefully at first, right? And then you get pretty good at it. As they get older, it gets easier. But when the mice are, you know, feet down, back up, you know, you can't really tell.

00:35:46 Speaker_00
You can't really tell. As the mice get older, their testicles become visible in the males, even from above. But as far as I know, there aren't really external markers. So you may have found the one truly external biomarker of maleness.

00:36:02 Speaker_01
Of maleness. And so I do want to say one thing about females, because then that'll lead me to my conclusion about the role of this measure. So if the mother

00:36:15 Speaker_01
is exposed to more testosterone than expected, you might expect that her female offspring would have a more male in a genital distance.

00:36:27 Speaker_00
Is that the case? Yes. So it's a bi-directional effect. Yes. Can we also presume that if the mother either secretes or is exposed to more androgen, then the males can become hypermale?

00:36:39 Speaker_01
No. I don't know what that would be. We never saw anything that would be hypermale. So the yes I said to you was the result of a study where we looked at the girls born to women with PCOS. So women with PCOS, as you know, have excess testosterone.

00:37:00 Speaker_01
Polycystic ovarian syndrome.

00:37:02 Speaker_00
Oh, sorry. Polycystic ovarian syndrome. We've talked about it a little bit before in the podcast. It's associated with, my understanding is it's associated with elevated levels of androgens.

00:37:13 Speaker_01
That's right. And these women often have facial hair and, you know.

00:37:18 Speaker_00
Not just the moms, but the people, the women with PCOS.

00:37:22 Speaker_01
Yes.

00:37:23 Speaker_00
Have elevated androgens. Yes. Not just, we're not talking about pregnant moms. Exactly.

00:37:29 Speaker_01
And so in our study, population, we did a search for women who had diagnosis of PCOS and took that as a marker of higher testosterone exposure, and then looked at the girls.

00:37:39 Speaker_01
And yes, those girls had a longer, quote, more masculine intergenital distance.

00:37:45 Speaker_00
What age group were you looking at?

00:37:47 Speaker_01
In the infants. Oh, the PCOS was at pregnancy, at the time they were pregnant.

00:37:54 Speaker_00
So presumably people between their like, somewhere in their 20s out to their 40s. So adult human females who have PCOS tend to, we know they have higher levels of androgens, but they also have more male-like anogenital distance.

00:38:11 Speaker_01
They do not, their daughters do.

00:38:13 Speaker_00
Their daughters do. Thank you for that clarification.

00:38:15 Speaker_01
Their daughters. And so put this together, And this measure is a look inside the womb at the androgen level that the fetus is exposed to at that time, which is amazing because you can't go in there without disturbing, you know, you can't.

00:38:39 Speaker_01
And so this is very early first trimester, you can't even get, you know, fluid and so on. So this tells you, this is like a readout of what was in you know, in the fluid at the time.

00:38:53 Speaker_01
So then your next question was, what does this mean for later fertility? Yes?

00:39:03 Speaker_00
Yeah, what is the impact of this early androgen exposure to female offspring, or let's just say reduction in fertility functional androgen exposure to male offspring.

00:39:18 Speaker_00
The reason I'm using these loop-de-loop languages, as you probably know, but for the audience, not trying to complicate things here, but a lot of the masculinizing effects of hormones in fetal development is actually testosterone that's converted into estrogen.

00:39:34 Speaker_00
So it can get pretty tricky. But maybe for sake of simplicity today, we'll just stick with androgen effects on masculinization with the understanding that some of those effects are the consequence of testosterone being converted into estrogen.

00:39:50 Speaker_00
It's just that people form such strong associations falsely that testosterone is maleness and that's not true. And estrogen is femaleness and it just gets really murky. But for the time being,

00:40:07 Speaker_00
you identified an external biomarker of fetal androgen, aka masculinization via the mother.

00:40:16 Speaker_01
That's right.

00:40:17 Speaker_00
Got it.

00:40:18 Speaker_01
Okay. So then we asked the question you've asked and many people asked, who cares? Why would we worry about a boy having a slightly smaller anogenital distance?

00:40:35 Speaker_00
Well, I can tell you there are many boys that are probably worried about it right now. They probably got the ruler and the calipers out right now.

00:40:44 Speaker_01
But I'm going to answer that question.

00:40:46 Speaker_00
Right.

00:40:47 Speaker_01
So I told you that our kids are too young. They're not producing sperm right now, right? So we had to go to an adult population, right? And so we went to a population of college students in Rochester, New York.

00:41:04 Speaker_01
And what we did there was make an assumption which is based on animal data. It's true in animals. We've been following the animal path here all along. So in the animals, my colleague, Earl Gray, who did these studies- His name is Earl Gray? Yeah.

00:41:22 Speaker_00
That's cool.

00:41:23 Speaker_01
Yeah. He said, AGD is forever.

00:41:29 Speaker_00
Anogenital distance is forever.

00:41:31 Speaker_01
Now, what that means is it's not like your anogenital distance today is what it was when you were born. Of course, you're a bigger person, but that means adjusted for body size, right?

00:41:41 Speaker_01
So if you assume that AGD is forever, if you're born with a short for your size AGD, then when you're 20, you'll have a short for your size AGD. Okay? Can we assume that? Okay.

00:41:53 Speaker_01
So if we assume that, then if we get these college students to come in and we can measure their anogenital distance, we're getting a reflection of what it was when they were born. Okay? And then we can get their sperm count.

00:42:10 Speaker_01
And then we can see if they're related. And that's what we did. So we got this population of Volunteers paid him $75, and one of the guys said, for 75 bucks, you can do anything.

00:42:25 Speaker_01
And so what we did was we measured their intergenital distance and then we got them to give us a semen sample and complete a questionnaire and things you do in a study.

00:42:36 Speaker_00
We'll link to that study, but I have a couple of questions about the controls in that study, just for sake of people understanding how a study like this would be done.

00:42:43 Speaker_00
I don't expect you to recall all the details, but you're adjusting for body size and body weight.

00:42:50 Speaker_01
Yeah.

00:42:50 Speaker_00
height, weight, what are the factors that would scale here that would allow you to normalize? In other words, what you're trying to do is backtrack to what it likely was at infancy.

00:43:01 Speaker_01
No, we didn't actually try to go back. Let me just tell you what the results were. In this group of men, if they had a longer anogenital distance, they had a higher sperm count.

00:43:14 Speaker_00
Got it, so you would correlate those two measures.

00:43:17 Speaker_01
Right, and then if we wanted to say something about, we didn't try to say anything about how it was when they were born. We just said, okay, we'll take that assumption that this reflects their early AGD.

00:43:29 Speaker_01
If we want to say something about early AGD and sperm count. So it's easy to say AGD is related to sperm count because we measured that, we saw that, a correlation. That's published. Okay.

00:43:42 Speaker_01
If we want to say their early AGD at birth and their sperm count, that's a leap of faith in some sense, because we don't have their early. For these guys in Rochester, we didn't measure their AGD at birth.

00:43:56 Speaker_00
So- Were there any conditions of being a participant in the study, such as refraining from alcohol, cannabis, et cetera, in the 90 days prior, 90 days being the- I don't think so. Duration of a spermatogenesis.

00:44:08 Speaker_01
Yeah, I don't remember that.

00:44:09 Speaker_00
These are college students, so presumably some of them are drinking, okay. So, but in the end, it was a robust link.

00:44:16 Speaker_01
And then Mike Eisenberg, who you might know at Stanford.

00:44:19 Speaker_00
Yeah, my colleague at Stanford. He's been on this podcast.

00:44:21 Speaker_01
Yeah, good, good. So he's a colleague of mine too. And he looked at men in a fertility clinic and those who had born children and those who had not born children.

00:44:33 Speaker_01
And the men who had born children had a longer, in a general distance, than men who had never born a child.

00:44:39 Speaker_00
never born, but we're trying. These were not people who opted out. These were people who were having challenges with fertility versus success with fertility.

00:44:51 Speaker_01
And by the way, you know, the question of how you measure AGD in an adult man is a different question than how you measure it in a newborn. And we did a lot of work on that and Michael helped with that too.

00:45:03 Speaker_00
So it sounds like, oh, and may I ask, were the sperm counts that were on the, let's just say the lower, like the lower quartile, were the quote unquote lower sperm counts, like functionally lower? Because I always wonder about this.

00:45:19 Speaker_00
Like it's come up in a number of discussions, like with Robert Sapolsky, with Mike Eisenberg, and now I'm asking you. And when we hear that sperm counts are going down, are they going down to the point where fertility is impacted?

00:45:31 Speaker_00
That's really one of the, I think, functional questions.

00:45:35 Speaker_01
So I'm gonna, let's lay aside the question of AGD, right? That's really interesting, but let's talk about sperm count. Okay, so there's a beautiful study among pregnancy planners out of Denmark quite a long time ago.

00:45:59 Speaker_01
And in that study, what they did was take couples that were trying to conceive that had never, or not recently, I can't remember, used oral contraceptives. And then they saw what the sperm count was and how long it took them to conceive, right?

00:46:18 Speaker_01
Time to pregnancy in relation to... And what they showed is a really interesting curve, which has never been correct it to my knowledge. It's what I use and what I think people use, which is that if you, I wish I could draw it here.

00:46:34 Speaker_01
You should have a board.

00:46:35 Speaker_00
The problem is a lot of people are listening, but maybe we can talk people through it.

00:46:40 Speaker_01
So just think about a curve where you go all the way down to zero, that would be no sperm. And then as the probability of conceiving is zero, so you're looking at sperm count along the X axis and months to conception.

00:47:00 Speaker_01
And what you see is that if you have no sperm, you don't have no conception. If you go up to around 40, 45, there's a steep increase. So the more sperm you have,

00:47:12 Speaker_00
40, 45 million?

00:47:13 Speaker_01
Million per milliliter.

00:47:14 Speaker_00
And this is million per milliliter, so just pure concentration, not number of motile sperm. This is just how many sperm? We're not talking about quality, we're talking about number. No, no, no, just the number.

00:47:23 Speaker_01
And when you have 45 to 50 million per milliliter and below, it matters a lot what your sperm count is. You know, people say, does it matter?

00:47:33 Speaker_01
Yeah, if you get in this range where the probability of conception is dropping off really rapidly, it matters a lot. And then around 45 to 50, it starts to level off.

00:47:44 Speaker_01
And then after that, after certainly after a hundred, probably 75, it doesn't matter at all.

00:47:50 Speaker_00
So a hundred million sperm per milliliter of semen.

00:47:55 Speaker_01
Yes. So can you see this? Okay. So when people say, does sperm count matter for fertility? Yes, it matters a lot if it's low. And no, it doesn't matter at all if it's high. So we just have too many sperm. I mean, I don't, but humans, you know.

00:48:15 Speaker_00
And there's- So nature runs a probability game. Overproduced sperm.

00:48:19 Speaker_01
Right.

00:48:20 Speaker_00
Some of those will be high quality, some will be low quality. Exactly. Depending on their age, that is when they were generated.

00:48:26 Speaker_01
Or their conditions, you know.

00:48:27 Speaker_00
Or their conditions, how much heat exposure, et cetera. So nature runs a probability game.

00:48:31 Speaker_01
That's right.

00:48:32 Speaker_00
Hoping that the best quality sperm will fertilize the egg. Right. So below 45,000, excuse me, below 45 million. Below 45 million sperm per milliliter of semen, the sperm count really matters. It drops off precipitously.

00:48:54 Speaker_00
Once you get up to 75, 100 million per milliliter of sperm.

00:48:58 Speaker_01
It's all good.

00:48:59 Speaker_00
You're good to go. Right. And sperm counts range anywhere from, you know, it could be low eight, nine, 10 million per milliliter in the very low situation. It could be zero. It could be zero in some people, right? All the way up to 400 million.

00:49:15 Speaker_00
There's a huge range.

00:49:16 Speaker_02
That's right.

00:49:16 Speaker_00
And that's a function of age. It's a function of genetics. It's a function of presumably phthalate exposure.

00:49:22 Speaker_01
Yeah.

00:49:24 Speaker_00
I'd like to take a quick break and thank one of our sponsors, Function. I recently became a Function member after searching for the most comprehensive approach to lab testing.

00:49:33 Speaker_00
While I've long been a fan of blood testing, I really wanted to find a more in-depth program for analyzing blood, urine, and saliva to get a full picture of my heart health, my hormone status, my immune system regulation, my metabolic function, my vitamin and mineral status, and other critical areas of my overall health and vitality.

00:49:51 Speaker_00
Function not only provides testing of over 100 biomarkers key to physical and mental health, but it also analyzes these results and provides insights from top doctors on your results.

00:50:01 Speaker_00
For example, in one of my first tests with Function, I learned that I had two high levels of mercury in my blood. This was totally surprising to me. I had no idea prior to taking the test.

00:50:11 Speaker_00
Function not only helped me detect this, but offered medical doctor-informed insights on how to best reduce those mercury levels, which included limiting my tuna consumption, because I had been eating a lot of tuna, while also making an effort to eat more leafy greens and supplementing with NAC and acetylcysteine, both of which can support glutathione production and detoxification and worked to reduce my mercury levels.

00:50:33 Speaker_00
Comprehensive lab testing like this is so important for health. And while I've been doing it for years, I've always found it to be overly complicated and expensive.

00:50:41 Speaker_00
I've been so impressed by Function, both at the level of ease of use, that is getting the tests done, as well as how comprehensive and how actionable the tests are, that I recently joined their advisory board, and I'm thrilled that they're sponsoring the podcast.

00:50:54 Speaker_00
If you'd like to try Function, go to functionhealth.com slash Huberman. Function currently has a wait list of over 250,000 people, but they're offering early access to Huberman Lab listeners.

00:51:05 Speaker_00
Again, that's functionhealth.com slash Huberman to get early access to Function. We were on to the fact that sperm counts are dropping.

00:51:13 Speaker_00
There's a relationship to anogenital distance, and there's a relationship between anogenital distance and phthalate exposure. And then I asked the question, you know, okay, we're hearing about sperm counts dropping, but is it functionally relevant?

00:51:26 Speaker_00
Is that one of the reasons why fertility is dropping? And we've also got the female side where we've got women with elevated androgens. So we can talk about that a little bit later.

00:51:37 Speaker_00
And then, of course, we have the sociobiology piece, where people are opting out of the or it's also economics in some cases, opting out of having kids.

00:51:52 Speaker_01
So let's go back to sperm count, because we haven't really talked about that. It's a kind of a different path. And my introduction into phthalates was not through sperm count.

00:52:02 Speaker_01
It was through this question of my colleague asking me, you should look at this. I'm challenged. And I looked at it, and that was a really, really interesting journey that I went on. But there was a separate. for a while journey that I was on.

00:52:17 Speaker_01
And that started in the late 1990s when I was asked to join a committee of the National Academy of Sciences.

00:52:27 Speaker_01
And that committee was assembled to look at the question of whether hormonally active chemicals, endocrine disrupting chemicals in the environment posed a threat to human health.

00:52:42 Speaker_01
Because at that time, it was like, well, yeah, we hear about this, but should we care, right?

00:52:48 Speaker_01
And so that committee wanted to consider a study that had come out of Denmark a few years earlier, which claimed that sperm count had dropped 50% in 50 years.

00:53:05 Speaker_00
That's a huge drop.

00:53:07 Speaker_01
That's what we're seeing worse than that, by the way, now. So, okay. They said to me, I was the only statistician on the panel, would you look at this and see if we need to consider this in our deliberations?

00:53:20 Speaker_01
And as I mentioned, I'm skeptical and I looked at it and I thought, eh, I don't think so. That was my initial reaction. And that was because First of all, I didn't know who had written this. I just saw it in a journal.

00:53:35 Speaker_01
And it was not very big and not very many figures, not very much data. And I thought of it, and I thought, that's a big claim for a little paper. But I'll look at it, because it's important. And so what I did then was to think about all the factors

00:53:57 Speaker_01
that we epidemiologists call confounders, things that might have caused that decline if it wasn't real biologically. And so we could think of some of them together.

00:54:13 Speaker_01
Maybe the method of counting sperm had changed so that later methods counted fewer sperm in the same sample. That's certainly possible. But it turned out that wasn't the case because they actually had all used the same method.

00:54:28 Speaker_01
And maybe the men had changed. You can't get a sperm count at random. You have to get somebody to volunteer, right? So who were these men?

00:54:37 Speaker_01
Were they very different in the early part of the study and the late part of the study in a way that maybe in the late part of the study there were men with lower sperm count and they were more concerned? Maybe they were more obese.

00:54:51 Speaker_01
That's pretty plausible. Obesity is related to sperm count, fertility. And maybe they smoked more, and so on and so forth.

00:55:01 Speaker_01
So what I did was to get the 61 studies, go through them, and try to extract information on all the factors that could explain the decline. So I created a multivariable model and ran that model.

00:55:22 Speaker_01
And to my astonishment, when I was done, the slope of the decline was exactly the same to the first decimal place. It had not explained anything. And I was like, oh my God, this looks like it might be real.

00:55:42 Speaker_00
And for those listening, what Dr. Swan is describing is being the excellent scientist that she is, she went and looked for all the things that could impact the result that were not related to what the main conclusion seemed to be, which is that sperm counts were going down over time, right?

00:56:02 Speaker_00
And this is really important to,

00:56:05 Speaker_00
because I think what we're talking about here in parallel to the main conversation is how to do really great science, especially in human populations that are out there living, you know, some of these men probably, you know, smoke some cannabis.

00:56:17 Speaker_00
I'm not saying that reduces sperm count. It might reduce sperm motility, however, we covered that in the podcast. Now that all the cannabis folks go, well, you know, so-and-so got so-and-so pregnant when they were doing a lot of weed.

00:56:29 Speaker_00
And I always say, okay, well, there are a number of other factors, right? But alcohol, there's frequency of ejaculation, right? The requirement to abstain for 48 to 72 to hours to up to five days prior, et cetera.

00:56:44 Speaker_00
All these factors that men may or may not faithfully report, but you assume that if some are telling the truth and some aren't, that there's an equal distribution of that. So all the different things, right?

00:56:55 Speaker_00
This is so very different than looking at, for instance, ovarian reserve, like the number of eggs, where you use ultrasound and you use AMH levels. And sure, things can impact that, but it's a little different than when we're taking sperm counts.

00:57:12 Speaker_00
So thank you for doing the study so carefully and for repeating them so many times. I mean, many of the studies that you've done, you've done follow-up studies. on the sperm count studies across multiple years.

00:57:25 Speaker_00
You know, as you said, the first study was in 1992, then you did one in 2017, then there was one again, and there was an update I noticed online. So you are extremely thorough.

00:57:34 Speaker_00
And it probably reflects your early training in math and statistics and probability theory. You're not somebody to just kind of go in and go, oh yeah, like in these people that eat a few too much of this, then there's a little bit less of that.

00:57:47 Speaker_00
So I just wonder if today's discussion feels like we're really, we're lathing through this, that's intentional.

00:57:56 Speaker_00
And it's important for people to hear these kinds of claims are not the sort of thing that you could, people make them all over the board, but work like this needs to be done with an extremely meticulous eye and consideration of all the variables.

00:58:10 Speaker_01
Yeah.

00:58:12 Speaker_00
And I would say, especially with human epidemiological work, because of the number of potential confounding variables.

00:58:19 Speaker_01
So when I saw that and actually did another study to select my own studies and not accept her 61 studies that had been published, that Elizabeth Carlson had published, so new studies, came up to more recent times, went back further, did it again, found exactly the same thing.

00:58:39 Speaker_01
Okay, so there were three looks at that and I thought, okay, I'm going to accept this now. This is, sperm count is declining. And why? I turned to the why. Because up and down now, we hadn't said anything about why. We just said, is it doing that? Yes. OK.

00:58:58 Speaker_01
Now we believe it is declining. Why? And so then I thought quite a lot and talked to people and ruled out genetics because it was too fast. It's two generations. It's too fast. 50 years, two generations. So if it's not genetics, then it's environment.

00:59:14 Speaker_01
And so what is it about the environment that could do this? So I asked, OK, in the environment, there could be things that are making sperm decline.

00:59:28 Speaker_01
So if you think about how you might look at that, you might design the study that I design next, which is another study. And by the way, this preceded the AGD. So we had four cities in the United States that we picked with different environments.

00:59:45 Speaker_01
And then we got men to come in and we used The same equipment at each place. We used the same method of selecting the man. The technicians were trained centrally at UC Davis.

00:59:59 Speaker_01
We had very good quality control, so samples were sent around every quarter to make sure that everybody was measuring things the same way. We didn't want drift, right? And then we got their urine. And that's how I had those urine samples.

01:00:14 Speaker_01
So if you wanted to do this study and you wanted to get a representative sample of men, where would you go? Because I can't ask a guy in the street to give me a semen sample right now. It's not something you'd get very, you know.

01:00:29 Speaker_01
So I thought, how can I get a representative sample And which would teach me something about a larger population called the parent population. So here's a sample, it should represent the parent. So how do I ensure that?

01:00:43 Speaker_01
And what I decided was to sample partners of pregnant women. Because pregnant women all come to medical care, almost all. And if their partners will give a semen sample, then we have a representative sample. And we know what we're looking at.

01:00:59 Speaker_01
So that's what we did. So this is a, the semen study is the, study of partners of pregnant women and of course they'll have slightly higher semen quality because they got their partner pregnant but and so we had their urine, we had their blood and

01:01:19 Speaker_01
We looked at their semen quality, and then we decided to look at pesticides. And the reason we look at pesticides was because there was a lot of gradation across our four centers in pesticide use.

01:01:34 Speaker_01
And what we found was really extraordinary that men who were living in central Missouri, where I was living at the time, who were in the middle of a agricultural belt where there was spraying all the time for soybeans and so on.

01:01:52 Speaker_01
Those men had half as many moving sperm as men in Minneapolis.

01:01:59 Speaker_00
Whoa.

01:02:00 Speaker_01
Whoa. Huge, right? And then we went one step further, and within Missouri, we looked at a sample of men who had very high

01:02:14 Speaker_01
sperm parameters and very low sperm parameters and showed that five pesticides were significantly higher in the men with the low sperm parameters. That includes motility, morphology, you know, all the parameters.

01:02:26 Speaker_00
So these are pesticides that are being sprayed in the air on crops. You mentioned soybeans. What other types of crops?

01:02:33 Speaker_01
I don't remember.

01:02:35 Speaker_00
So plant and fruit crops.

01:02:38 Speaker_01
Yeah, whatever they were growing in Columbia, Missouri at that time.

01:02:42 Speaker_00
And just to make sure I understand. It's not that the men need- Soybeans, corn and soybeans. Corn and soybeans. But we're not talking about eating corn and soybeans.

01:02:51 Speaker_00
We're talking about living in an area where pesticides are being used by, I guess, is it still called dust crop?

01:02:58 Speaker_01
Yeah, we didn't go into how they got these. We just looked in their urine and there were the metabolites. The metabolites don't get in their urine unless they were exposed.

01:03:07 Speaker_00
exposed through the air or exposed by eating corn and soybeans? We don't know. We don't know. OK.

01:03:11 Speaker_01
We don't know. But this was not a particularly, we didn't sample farmers only or anything like that. So whoever came in to the, remember how we got these men? Their wives were pregnant. They were having prenatal care at the University of Missouri.

01:03:27 Speaker_01
So that's where we got them. Whoever happened to come in to the prenatal clinic and agree to be in our study, they're the male. you know, urine, male's urine was measured for these pesticides.

01:03:39 Speaker_00
I'm sure a number of people, including myself, are wondering in what other products are these five pesticides present. Are these commonly used pesticides or is it something about... They're called the triazine pesticides.

01:03:57 Speaker_01
Atrazine was the most widely used and it's a huge use around the world. I mean, it's highly, you know, one of the most, the largest commercial pesticides. So these were very big players in the pesticide field.

01:04:11 Speaker_00
A relevant theme there would be, maybe we could take a moment and talk about atrazide and its effect on male sexual behavior in amphibia.

01:04:21 Speaker_00
And we'll come back to the sperm studies because when I was a graduate student at UC Berkeley, I had the wonderful experience of taking a course from the now I think you mentioned he's a dean. There are multiple deans on campuses.

01:04:35 Speaker_00
Tyrone Hayes is a wonderful researcher who established a link through his research between atrazine exposure and male sexual behavior of amphibia. Could you elaborate on that result?

01:04:52 Speaker_01
Yeah, so Tyrone first caught frogs in the wild in environments that were more or less exposed to atrazine and showed effects on development and sexual behavior. Then he, in his lab, he actually exposed them.

01:05:08 Speaker_01
So he knew exactly who was exposed and how much, and he showed that And I can't tell you what percent or what, you know, but a significant number of frogs exposed to this pesticide atrazine chose to mate with other male frogs.

01:05:27 Speaker_00
Tried to mate with other male frogs, presumably unsuccessfully.

01:05:30 Speaker_01
Well, they mounted them. He has photos of the males mounting males.

01:05:35 Speaker_00
And so presumably this is a neural change that occurred, neuroendocrine change, but ultimately neural since mounting behavior is controlled by Actually, we now know the hypothalamic nuclei that control this.

01:05:49 Speaker_00
David Anderson, who's been on this podcast, has people in his laboratory that, including a former graduate student of mine, working on this specific issue of what the circuitry is. That's a remarkable result. It's been kind of...

01:06:09 Speaker_00
you know, used and misused out there in the media and in popular culture.

01:06:15 Speaker_00
But if nothing else, it suggests that the organization of the neural circuits and neuroendocrine pathways that control sexual, I don't want to say partner, because there's mating thing, frogs aren't monogamous, but sexual preference are significantly impacted by this atrazine.

01:06:37 Speaker_01
Yes, and it suggests that other environmental chemicals can as well. And I don't know if we'll have time to go there, but I did work on neurodevelopmental outcomes in relation to prenatal phthalate exposure.

01:06:53 Speaker_01
And so I think the overarching idea here is that the brain, like the genitals, is sexually dimorphic. And there's many people, by the way, who will take offense at that.

01:07:07 Speaker_00
Yeah. I think there's, I mean, going back to the work of Frank Beach in the psychology department at UC Berkeley, showed this in beagles. It's been shown in pretty much every species, but it's not a better, worse.

01:07:20 Speaker_00
I think this is what people need to hear. Like dimorphic does not mean better, worse. It means different.

01:07:24 Speaker_01
Right. And that there are, for example, advantages to spatial, reasoning in a male, which are related to testosterone, right? You know that.

01:07:39 Speaker_00
I mean, I think there, yeah, I mean, my understanding of this literature, and I'm not an expert in this particular aspect, which is the behavioral phenotypes.

01:07:47 Speaker_00
But, you know, like the medial preoptic area of the hypothalamus is known to be sexually dimorphic, dependent on testosterone, converted into estrogen during development, et cetera, et cetera. And there's just so much evidence of this.

01:08:01 Speaker_00
how it links to behaviors I think can be reasonably placed into ethologically relevant, evolutionarily logical arguments when talking about rodents or beagles or even rhesus macaque monkeys.

01:08:18 Speaker_00
I think where people get a bit inflamed is when people try and take the sexual dimorphisms that have been observed in animal brains or even in human brains and tack those to specific abilities or lesser abilities.

01:08:34 Speaker_00
I think that's when people sort of go, wait a second, like I have much better sense of direction than my husband. And you go, well, yeah, like, you know, and then you go, well, well, does that mean that she has higher testosterone than him?

01:08:43 Speaker_00
And then maybe, and then, and pretty soon you're, you're in almost a no man's land, a no person's land of confounding variables, right? But I really appreciate that you raised this and also that you said it and I didn't because I feel safer that way.

01:08:59 Speaker_01
But look, there is a very simple, outdated questionnaire and it's play behavior. It's called the PSAI. It's been used for years. Have you heard of it?

01:09:11 Speaker_00
It's a rough-and-tumble play.

01:09:13 Speaker_01
Yes.

01:09:13 Speaker_00
Yeah.

01:09:14 Speaker_01
Yes. And there are 24 questions on there, and they are sexually dimorphic, I guess you could say. My child likes to play with dolls. My child likes to play dress-up. My child likes to play rough-and-tumble, et cetera. And we gave that questionnaire.

01:09:33 Speaker_01
to our population and looked at the answers that the mothers gave, both in our population, by the way, and a Swedish population of a colleague there, Carl Bornahag and Gustav Bornahag.

01:09:50 Speaker_01
And what we found, higher phthalate levels, these antiandrogenic phthalates, were associated with less masculine male typical play in our male boys.

01:10:06 Speaker_00
So- This is phthalate exposure- In utero. To the mom, baby is born in the young human child.

01:10:15 Speaker_01
Yeah, I think it was four years of age.

01:10:17 Speaker_00
Four years of age, less rough and tumble type play- That's right. Among the boys whose mothers were exposed to more phthalates during a critical period of development.

01:10:26 Speaker_01
Now you can see that's a politically loaded issue now.

01:10:32 Speaker_00
Well, I think we're, I mean, let's have some fun with this in the scientific sense. The notion of dimorphism is, you know, okay, male and female brains are different, right?

01:10:44 Speaker_00
And male, female defined in those, almost all those studies as presence of a Y chromosome. And then people say, well, there's XYY, and then there's XXY. Okay, but most of the time you're talking about XX chromosome or XY chromosomes at birth.

01:10:56 Speaker_00
Forget everything else for the moment. these are always distributions. This is what I think people need to know. We're not talking about, these are not, this is not, you know, two hills of data separated by a valley.

01:11:11 Speaker_00
These are overlapping distributions, right? So you get males with a quote-unquote female-like distribution, you get females with a quote-unquote male-like distribution. And I think as long as we acknowledge that, And we're just talking statistics.

01:11:25 Speaker_00
We're not placing any cultural or any value on it really whatsoever.

01:11:31 Speaker_01
Right. But if you could make the analog to the intergenital distance, it's kind of similar. You know, you have the same exposure, phthalate exposure, you have something changed statistically. We don't see huge differences in the boys' genitals.

01:11:45 Speaker_01
And we don't see huge, I don't, we know these kids have not been scanned, so we don't know how their brains look. Based on their answers, we don't see huge differences. We see tendencies.

01:11:55 Speaker_01
We see they are more likely, if they had been exposed to these phthalates, to want to play dress up and have tea parties. More likely. Doesn't mean that they're all going to, but that's the direction and so on.

01:12:09 Speaker_01
So I think we have to just think about more likely, not absolute. Yeah.

01:12:13 Speaker_00
And of course, there are also the sociobiological variables, such as if, a young boy has a sibling that's a sister, there's more likely to be dresses around, right?

01:12:27 Speaker_00
If he has two older brothers, there might be more rough and tumble play happening in the house.

01:12:31 Speaker_00
And I have some friends that are women who have older brothers and those women are, you know, some of them roll jujitsu or do, you know, and I know some women who are only children who do martial arts and fight, right?

01:12:46 Speaker_00
So I think that none of this is deterministic as we know,

01:12:50 Speaker_01
But let me just add, we did control for the sex of the older sibling, and we also asked about the parent's attitude towards same-sex play. So how would you feel if your child, your male child, played with dolls? Would you be discouraging?

01:13:09 Speaker_01
Because it has a lot to do with what's in the house. If you say, does your child play with dolls? Well, what if there were no dolls?

01:13:15 Speaker_00
This is super interesting to me. I don't want to reel too much, just because it's just an N of one. But I grew up in a household where

01:13:23 Speaker_00
I have a sister, but then after a certain age, I received very strong messages about what sorts of play were gender appropriate. And I think I also just naturally defaulted to, there were a bunch of boys that lived in my neighborhood.

01:13:39 Speaker_00
They had older sisters. So all the sisters hung out together. It's kind of interesting. And all the younger brothers pretty much hung out together. And the guys that weren't, didn't have siblings or had brothers for siblings.

01:13:48 Speaker_00
So there was a really strong divergence, but I grew up in the, that was in the seventies and early eighties when things were, let's just say culture was more dimorphic then. Clearly.

01:13:57 Speaker_00
I mean, there were television shows like All in the Family, which the entire basis of the show was the wife going back to work and the husband being confused about it. I mean, nowadays, people will go like, what? That's wild.

01:14:07 Speaker_00
I have to ask, because I know people are wondering. And I'm wondering, what are some non-pesticide sources of phthalates that we have agency over, that we can take control over?

01:14:19 Speaker_01
Right, so let me correct you. It's not the sources of phthalates necessarily. Pesticides, there are phthalates in pesticides, but that's not the worst player in the story. If you look at the different classes exposures that are hormonally active, right?

01:14:44 Speaker_01
Pesticides are, phthalates are, bisphenols, like bisphenol A. BPA. BPA, certain metals are, there's the PFAS chemicals, there's all these different classes, right? And if we want to go into what in our daily life exposes us to these things.

01:15:06 Speaker_01
That's another story that we can talk about, but they're gonna be different depending on the class, right?

01:15:15 Speaker_00
So let's throw our arms around all of those for the moment. And I'll just ask you, given that you're an expert in this area, what are the top three to five sources of endocrine disruptors that we have agency over.

01:15:33 Speaker_00
And let's forget about pregnancy for the moment, since we're all out of the womb if we're listening to this. Some people will be pregnant as they listen to it, but would you say it's, you know, drinking out of plastic bottles? Is it laundry detergent?

01:15:50 Speaker_00
Is it, you know, rubber tires that are cascading down on us through the air and we're inhaling them? I mean, presumably all of the above, but what are,

01:15:58 Speaker_00
which ones that we have agency over do you think are the most, let's just say concerning where people could make better choices?

01:16:08 Speaker_01
I would say foodborne exposures, exposures in the food, in the food packaging, in the food storage, in the food, in the cooking utensils. We can go through the various things, but, We're doing that all the time. We're eating all the time.

01:16:31 Speaker_01
We're getting food into us. And these are bringing in a way that we have some control over, some agency over. We can make changes in our foods. Very close to that is drink, food and beverage. So I... First of all, I've talked about this a lot.

01:16:56 Speaker_01
I've written about it in my book. I'm also, as you know, involved in a movie where, in the movie, that might be a good time to talk about that. What we do in the movie, the movie is about six couples that are infertile.

01:17:11 Speaker_01
They haven't been able to conceive in 12 months, that's the definition. And then a company that I work with, Million Marker out of Berkeley, has a trained staff that interviews them. Not only them, but anyone who signs into the agency.

01:17:28 Speaker_01
to this company, interviews them and asks them what they use. What do they use for their facial care? What do they use for their shampoo? What do they use for their cleaning products and their laundry detergent? What do they store their food in?

01:17:41 Speaker_01
And on and on and on. This is long inventory that they take of all products that people are aware of using. Based on that, we identify likely bad players in the list. So, how we do that is another, you know, we can talk about that later.

01:18:04 Speaker_01
then in the film and in this little it's actually an experiment that I designed and we're called an intervention and we are then intervening in their exposures by changing out these things that they told us so we will tell them you know

01:18:23 Speaker_01
don't use any product with fragrance, for example. That's a major source of exposure to phthalates.

01:18:29 Speaker_00
Any product.

01:18:30 Speaker_01
Any fragrance product.

01:18:32 Speaker_00
No perfume, no lotions, soap with fragrance, even essential oil fragrances.

01:18:38 Speaker_01
Essential oil is a tricky... It's a mix. It's a mix, yeah. So I'm gonna, that's guarded. But anything, you know,

01:18:47 Speaker_00
Spray deodorants, roll-on deodorants.

01:18:49 Speaker_01
Laundry detergent.

01:18:50 Speaker_00
Shampoo.

01:18:51 Speaker_01
Yep, and any, if you can smell it, it's probably affecting your hormones.

01:18:57 Speaker_00
I'm so happy about this answer, not because I have any stake in any company related to fragrance-free stuff, but I have a very strong sense of smell and I either love or hate smells, and I hate synthetic smells.

01:19:09 Speaker_00
Like going through the duty-free, especially in a European airport with all the perfumes, and I'm just going to hold my breath. It feels like I'm breathing poison.

01:19:21 Speaker_01
Well, you are actually.

01:19:22 Speaker_00
Yeah. In some sense. And most soaps, right. Super interesting. So that's your primary intervention is to tell them get rid of anything with fragrances.

01:19:31 Speaker_01
No, that's only one thing we get rid of. So then we talk about how the plastics that they use to store their food, food storage containers. try to get them to get rid of those if they're made of plastic.

01:19:43 Speaker_01
We try to get them to get rid of their nonstick pans because of the PFAS chemicals that are in those, and so on and so forth. So we go through all steps of their life and try to tell them how to make changes that will reduce their exposure.

01:19:58 Speaker_00
But presumably also changes, like if the man is obese, for instance, you might have him walking a bit more. You don't touch any of that?

01:20:06 Speaker_01
Well, you see, Andrew, if we did that, we would be mixing up two interventions. We would be mixing up an obesity intervention

01:20:14 Speaker_00
I see, this is a study. I'm sorry, I thought that this group is missioned with helping couples get pregnant.

01:20:20 Speaker_01
No, no, this is a study to look at what happens if you make these product-related changes.

01:20:27 Speaker_00
Great, just product-related changes.

01:20:28 Speaker_01
Exactly, exactly. We would love to do and probably will do another study, separate one on obesity. And a lot of these chemicals, just to let you know, are obesogens, they increase obesity. There's a book out called Obesogens. You can read about them.

01:20:44 Speaker_01
And so there is some overlap. So by reducing some of these chemicals that are in your food storage containers, you're also reducing obesogens. So it's not a clear yes, no. We gave them a box, each couple.

01:20:59 Speaker_01
I went to their house, six couples around the United States, with a big box. And in this box are these alternative products. you know, straws and bamboo spoons and, you know, $500 per box, I think it was approximately.

01:21:17 Speaker_01
It had to do with their personal, you know, exposure. And then they made these changes. Now, unlike Another study that you reported, they are at the end quite happy to keep doing this, by the way. They love this. They love doing this.

01:21:36 Speaker_01
It was so gratifying to see that they felt in many, many ways their life got better. I'm pretty careful in what I, so I hesitate to say this because the data is not hard, but the impression is that they are happy, happier. They're sleeping better.

01:21:58 Speaker_01
They report more energy, and so on and so forth, having made these changes. We need to follow that up with hard data. I'm not writing that. But I can say, and I can write, that they felt very positive.

01:22:11 Speaker_01
And we're going to go back and see if they did continue. We need to do that. But at the end of the three months, and hopefully in six months, they are still making these changes in their lives.

01:22:25 Speaker_00
Did you collect data on whether or not they were able to conceive after having made these changes?

01:22:30 Speaker_01
Yes, we did, but I actually can't talk about that.

01:22:32 Speaker_00
Can't talk about it, until the babies are born, just kidding.

01:22:37 Speaker_01
And we did get their sperm count at the beginning and the end, and had some very interesting data on that.

01:22:42 Speaker_00
Too early to report.

01:22:43 Speaker_01
Too early to report.

01:22:44 Speaker_00
Let me ask you this then, and I appreciate the not wanting to share specific results until all the data are in and it's published.

01:22:56 Speaker_00
if somebody listening were having trouble conceiving for 12 months or more, are the sorts of replacement interventions, product interventions that you're talking about here, things that you would at least feel comfortable saying might be a good place to start or to explore?

01:23:16 Speaker_01
Absolutely, absolutely. There's no harm. You know, none of the changes are putting people at risk or doing anything that could be harmful to them. I'm sure of that. We're very careful.

01:23:27 Speaker_00
And some are going to be cost-saving. And I think that's where like drinking out of plastic bottles far less, if at all. Like just for reasons related to wanting to reduce waste, I use a Mason jar or I use these or ceramic.

01:23:42 Speaker_00
Although you'll probably tell me that the lining on the ceramic mug might have endocrine disruptors. No, I don't. Okay, great, okay. Well, then I'll keep drinking. But it's very reassuring to me that

01:23:54 Speaker_00
there are things that we can do in terms of cost-saving elimination or replacement of consumables.

01:23:59 Speaker_01
Buying in bulk.

01:23:59 Speaker_00
That can improve endocrine status, maybe fertility also.

01:24:02 Speaker_01
If you can buy in bulk, bring a container to the store and fill it up, a glass jar, instead of buying something in plastic, you're winning on both ends because those bulk products are cheaper.

01:24:14 Speaker_01
One of the things I did with the couples was go shop with them. And we went around and we looked at various products.

01:24:19 Speaker_01
And for example, we looked at the produce and there was the option to buy freestanding bunches of lettuce, heads of lettuce, or wrapped up in plastic bunches of lettuce. And I said, let's compare the price. I actually didn't know until we did it.

01:24:35 Speaker_01
But the freestanding unwrapped lettuce was cheaper. And I think that's, you know, because that makes sense. Cause there's a work involved in wrapping it up and in the container and so on.

01:24:47 Speaker_01
And so not only are you getting something that's more toxic, but it's more expensive.

01:24:53 Speaker_00
When it comes to reducing BPA exposure and some of these forever chemicals that you mentioned, seems like reducing fluid intake from plastic vessels is going to be number one.

01:25:06 Speaker_01
The primary source of BPA is in the lining of cans. So any drink or soup or anything that comes in a can is going to be- Any can, all cans. Any can.

01:25:24 Speaker_01
You know elite company that's made the change from BPA to an alternative lining and they'll say that so and by the way BPA has some bad relatives Such as BPS and BPF and maybe you'd be interested in this story.

01:25:41 Speaker_01
So when it came out that BPA was estrogenic, which is what it is and by the way, it's kind of the evil twin of phthalates because phthalates are anti-androgenic and BPA is estrogenic and phthalates make plastic soft and BPA makes plastic hard.

01:26:00 Speaker_01
You don't want either. Okay, so when this came out that this was a bad thing, the manufacturers started selling things that say BPA-free. I'm sure you've seen that. The trick is that instead of BPA, they use BPS.

01:26:16 Speaker_00
Sneaky rats.

01:26:17 Speaker_01
And BPF. And these are chemicals, these are lookalikes, they're analogs, and they're just as harmful.

01:26:23 Speaker_00
Sneaky, sneaky, sneaky. I'm not a conspiracy theorist, but it's just so dirty. It's so dirty.

01:26:30 Speaker_00
It's like, it's, you know, right now is a really important time to be having this discussion because there's been a lot of movement on Capitol Hill and there's been a lot of movement on social media about trying to call attention to metabolic syndromes and highly processed foods and issues like this.

01:26:46 Speaker_00
And it's become unfortunately politicized. I mean, I hear this stuff and I just think to myself, the only good faith

01:26:54 Speaker_00
that we can really trust is our own desire to be healthier and to have our families and friends be healthier and to try and consume and not consume things on the basis of that. My belief is that we can't trust any larger agency to either protect or

01:27:13 Speaker_00
harm us. It's like, it's not, it's, it's like, they're going to do what they're going to do. We just have to be informed as opposed to trying to like dismantle the systems that led to this, which just seems like infinitely complicated.

01:27:25 Speaker_00
Maybe you can do that, but I'm far less optimistic. And now that I'm 49 years old, I can say things like now that I'm 49, I feel like, but what you're saying is really important. If I look at a can, it says BPA free. It doesn't mean anything.

01:27:37 Speaker_00
It could have BPSs or other at endocrine disruptors. So drinking out of glass vessels, drinking out of ceramic vessels.

01:27:48 Speaker_01
Metal.

01:27:49 Speaker_00
Metal, but not cans, not metal cans, not aluminum cans.

01:27:52 Speaker_01
Right, not cans, no.

01:27:54 Speaker_00
Goodness, okay.

01:27:55 Speaker_01
But you can get a metal water bottle that's not lined with BPA.

01:28:00 Speaker_00
Steel. Steel, yeah. Steel. Is it true that microwave safe means it just means that the plastic won't melt in the microwave, but it's- You never, never put plastic in a microwave.

01:28:13 Speaker_01
So here's the story. The BPA, phthalates, plasticizers are added to the plastic, but they're not chemically bound to it.

01:28:26 Speaker_01
Okay, so if you put anything in a container that has these chemicals in it, they will, and then put it in a hot environment, they will come out of the plastic and go into the food.

01:28:42 Speaker_01
So if you, in a microwave, or you put your bottle in the car, and the sun comes in and it warms up the bottle, and then the stuff goes into your water.

01:28:51 Speaker_01
You don't want to mix these chemicals and your food, but if you do, the worst thing is to do it in a heated environment.

01:28:59 Speaker_00
Think about all the food that was consumed in college in the 90s and 2000s, like the cup of noodles with the styrofoam, the things in packaging. Stuff like that is pretty straightforward to eliminate once one understands and decides.

01:29:16 Speaker_00
Then we start getting into the more nuanced thing of like, okay, you can buy a really nice tasting anyway, grass-fed, grass-finished steak, but it's wrapped in plastic.

01:29:27 Speaker_00
Well, or you can go to the butcher, but most people don't have time to go to the butcher. Or you can get strawberries at the farmer's market, blueberries at the farmer's market, which is what I try to do.

01:29:37 Speaker_00
But sometimes I buy strawberries at the market and they have those plastic flip-top things. And of course I recycle the plastic. How bad is it if you rinse the strawberries off, good clean water that were in the plastic container. Are you-?

01:29:52 Speaker_01
We have to do that experiment, I don't know.

01:29:53 Speaker_00
Yeah. So I guess, so it sounds to me like not drinking out of cans, not drinking out of plastic bottles, it's going to be not microwaving plastic ever. And in general, just avoiding, avoiding plastic intake.

01:30:07 Speaker_01
If you can afford it, buy organic. So you're going to avoid the pesticides and then phthalates are actually added to pesticides. And they're added because they increase absorption.

01:30:18 Speaker_01
So you want your pesticides to get into the plant and to kill the bad stuff and insects. And so the same property of phthalates that makes them good for pesticides also makes them good for our hand cream. Just mentioning, absorption, absorption.

01:30:39 Speaker_01
Anything that's absorbed in the body is going to have phthalates in it. And it also holds scent and color. So it's added to those scents. And it's also added to your lipstick and to your colored, you know, whatever you put on your face and so on.

01:30:55 Speaker_01
Anything that holds scent and color, that's gonna be phthalates.

01:30:59 Speaker_00
I'm sorry. I've been accused online of being a sunscreen truther. I'm not a sunscreen truther. I'm gonna keep repeating this as many times as I can. I understand that, UV damage to the skin can cause certain cancers. I get that. I agree with that.

01:31:19 Speaker_00
The data are pretty clear to me based on having researched this pretty extensively and talked to many, many people, including dermatologists, that mineral-based sunscreens like zinc oxide,

01:31:28 Speaker_00
and titanium dioxide, but certainly zinc oxide are safer than the chemical sunscreens. A lot of people get upset when I say that. And they say, well, in Europe, there's tons of evidence that the chemicals based sunscreens are never safe. Okay, fine.

01:31:40 Speaker_00
You use them. I'm not going to. The point being that UV damage is bad. There are ways to protect ourselves from the sun, including physical barriers like clothing, hats, et cetera.

01:31:57 Speaker_00
but pretty much all sunscreen that I'm aware of is designed to be absorbed.

01:32:02 Speaker_00
So what do we do if we want to get some UV protection from whatever kind of sunscreen we deem safe for ourselves, but we want to avoid these exposures to these other things, what do we do? Do we have to hunt really carefully for the right sunscreen?

01:32:16 Speaker_01
Yeah, I think that's a good idea. Are you familiar with Environmental Working Group?

01:32:22 Speaker_00
Is there another one out of the Bay Area? No. Oh, okay. I don't know actually where they are.

01:32:26 Speaker_01
They're pretty big.

01:32:27 Speaker_00
Sounds familiar, but I'm not, I can't say I'm familiar with them.

01:32:30 Speaker_01
So they have consumer guides and in those consumer, so environmental working group, I'm not part of them. I'm not, you know, but I. like their work. And in these consumer guides, you can put in the product and they have categories.

01:32:42 Speaker_01
You can put sunscreen, if we had time, we could do it right now. And then you can put the name of your sunscreen and it'll give you a number. And then if the number is less than 10, it'll tell you why.

01:32:52 Speaker_00
Are they independent of any like funding? Yeah, they're totally independent. That question will probably come up for you too. people will say, where did she get her funding? People get very suspicious about this. I can tell you that.

01:33:07 Speaker_00
Yeah, that'd be great.

01:33:09 Speaker_01
So I am a tenure professor at Mount Sinai, get some salary there because I'm only part-time. And I have a funder, one funder, who funded my sperm decline, second sperm decline analysis and the publicity of my book. So it's a foundation.

01:33:29 Speaker_00
So it's philanthropy.

01:33:31 Speaker_01
Yes, philanthropy. And it's actually not a lot of money.

01:33:35 Speaker_00
And so there's no reason to think that anything that you're telling us is linked to like the food industry or an alternative product or anything.

01:33:42 Speaker_01
I'm very, very careful not to endorse any product because I don't want that complication.

01:33:48 Speaker_00
Thanks for clarifying that. I wasn't suspicious, but I think nowadays people have just been taught to, you know, appropriately so. They've been taught to say, well, wait, where does this funding come from?

01:33:58 Speaker_00
Because a lot of the studies that led to the food pyramid, for instance, people were under the impression that somehow that was biased by companies that were funding the work. And I don't know, I haven't done the forensics on that.

01:34:11 Speaker_00
I don't have the time or the energy. All I know is that when it comes to what people eat, when it comes to what people put on their body, it becomes a very personal thing and it's woven in with a lot of psychological and emotional issues.

01:34:29 Speaker_01
Yeah.

01:34:29 Speaker_00
Yeah. Okay. What are a few things that you do and or avoid in light of what you know about these endocrine disruptors.

01:34:44 Speaker_00
And by the way, it goes without saying that you're in spectacular cognitive and physical shape for any age, but it's really remarkable. I feel comfortable sharing this because someone else published it online recently.

01:34:56 Speaker_00
You are soon to enjoy your what birthday?

01:34:59 Speaker_01
89th.

01:35:01 Speaker_00
89th birthday, amazing. And with all the talk about longevity, cognitive and physical longevity, everyone's thinking, including me, like, what does she do? Well, she avoids all these endocrine disruptors.

01:35:11 Speaker_00
And she has a wonderfully rich life of curiosity and other things. But yeah, what are some other things that you do and avoid in light of what you know, for which there may or may not be a controlled study, but I think we're all just curious.

01:35:25 Speaker_00
We'll frame this as what you do.

01:35:29 Speaker_01
water, our water. I worry about the water. I studied water for a long time in my past life. So we actually distill our water. So we have a tabletop distiller. My husband, Steven, cleans it out.

01:35:44 Speaker_01
There's a lot of gunk in it, by the way, even though it's San Francisco that has clean water, at the end of the day, after you've distilled the water, there's a lot of gunk.

01:35:51 Speaker_00
So you distill the water. So this is not reverse osmosis.

01:35:54 Speaker_01
No, distilling. Yeah, so it's steam distilled, and then it condenses in a glass container, and then we put that in glass containers in the fridge. And it tastes really good, by the way. Really, really.

01:36:07 Speaker_01
Somebody was just over, and he said, this tastes like melted snow. I thought it was lovely.

01:36:13 Speaker_00
And you use that for drinking, for coffee, for tea, for cooking too. If you make rice, you're using distilled.

01:36:17 Speaker_01
Actually, no, no, no. But for ice cubes and, you know, whenever I can think about it, we can't use too much cause you'd be too busy. He does it once a day. It's just the two of us. So water is important. We try to leave our shoes at the door.

01:36:35 Speaker_01
Tell me about that one. Well, dust that you bring in contains a lot of the PFAS chemicals. So that's actually, I'm not 100% good on that, but we try to do that. And I'm careful with the products I put on my face.

01:36:56 Speaker_01
check them out the way I suggested, an environmental working group. And I go to the farmer's market. I always buy organic, always buy organic. But I know that's a cost issue for some people and an availability issue for some people.

01:37:12 Speaker_01
But in San Francisco, you can do that. Some areas where I don't do more of what I should, I think, I'm starting to be aware of the chemicals in clothing.

01:37:25 Speaker_01
We haven't talked about that, but there's a, turns out there's a lot of, particularly in, it's a problem for workout wear, because you're absorbing so much, you're sweaty, you're hot, and you're bringing these chemicals into your body.

01:37:38 Speaker_01
And that may be one of the interventions that we do. get a bunch of athletes to use safe clothing and traditional clothing and see what their body burden is.

01:37:50 Speaker_00
That's how you know. So erring toward cotton as opposed to synthetic materials?

01:37:57 Speaker_01
Right, and the dyes are important. So you want maybe plant-based dyes. It's not my area of expertise. I have a colleague who I work with on this, and I'll go with her advice.

01:38:07 Speaker_01
But I'm just saying that's another area that I think people will soon be paying attention to. There's also the area that is much more difficult, which is what's in building materials and furniture.

01:38:21 Speaker_01
But a lot of these PFAS and the flame retardants are in our furniture and in our building materials and trying to think about how to build. I was asked about safety in a new village that's being built in California, by the way.

01:38:34 Speaker_01
And it's really challenging to think about if you were going to do this right and you were going to build a town that was toxic free, how would you do that? I'm thinking about that.

01:38:48 Speaker_00
I'm thinking about the opener of the Simpsons and doing the exact opposite, where like in the opener of the Simpsons, there's like a three-eyed fish and there's the chemical plant.

01:38:56 Speaker_00
And I'm just thinking, you just look at the opener of the Simpsons, you do the inverse of everything that's there, the inverse of everything that's there, including alcohol intake, you know, which is robust on the Simpsons, but interesting.

01:39:12 Speaker_00
So, and when it comes to, food sourcing, like a non-fruit, non-vegetable food sourcing. Is there anything we can do? I mean, it's so hard for people to get eggs from farms.

01:39:24 Speaker_00
I mean, you can if you go to a farmer's market, but this stuff can get pretty tricky, pretty expensive. And most people listening are not gonna be living in Sonoma where they might have a a neighbor that has chickens or something. It's a hard problem.

01:39:40 Speaker_01
It is a hard problem. And I think maybe people asking for it more would help. I don't know. I mean, in San Francisco, I'm lucky because I can just get, you know, just on the phone, fresh direct order, and I know it's OK.

01:39:57 Speaker_01
But I know that's not the case everywhere. I think being aware, honestly, is a really big step. If you are aware that this is something you want to change, you will find ways to change it.

01:40:12 Speaker_00
It's interesting because a few years back, there was a lot of discussion about dyes in children's toys, in particular toys from overseas, right? Remember, kids are not young, babies are always gnawing on stuff and teething.

01:40:25 Speaker_00
And there was a lot of attention like, hey, like what's in these sippy cups? And my understanding is toys and sippy cups. And my understanding is that BPAs were banned from sippy cups. Phthalates. Phthalates, excuse me.

01:40:36 Speaker_01
Based on my work.

01:40:37 Speaker_00
based on your work. Thank you so much. Thank you for the clarification, truly, and for the work that led to that. We have this innate, thankfully, innate reflex to protect our young, as does every most every species, thank goodness.

01:40:55 Speaker_00
And we know that baby skin is more absorbent than older skin, we know. And so there are literally laws in place and restrictions in place to make sure that some of this stuff is minimized in young kids.

01:41:06 Speaker_00
But then we sort of, after age 12, we're kind of like, okay, well, it's a free for all, it depends on your budget, where you go. And so we can't rely on governing bodies to do this. Yeah.

01:41:17 Speaker_00
But I think it's a useful conversation, especially given your relationship to Scandinavia, which is a fun one to elaborate on, to illustrate some of the discrepancy between the US and Europe.

01:41:32 Speaker_00
What sorts of chemicals are banned in Europe, in food, in lotions, et cetera, that you're aware of that are prominent here in the US? Maybe that's a good filter to play some of this choice-making through.

01:41:48 Speaker_01
Europe has had a policy called REACH. And under REACH, you have to show that a chemical is safe before it's put into the marketplace.

01:42:02 Speaker_01
The way our system is here is put in the marketplace, and then if somebody gets worried about it, they might do a study, they might find harm. Remember how long it took me to find that phthalate connection?

01:42:15 Speaker_01
It was 10 years, two studies, 10 years, $10 million, by the way. If you're going to wait for that, I don't know, given the number of chemicals out there, 80,000 or more, forget it.

01:42:29 Speaker_01
I think the reach policy of testing before something's put in the market is making a big difference in Europe. I think that's one reason why they're much better off.

01:42:41 Speaker_00
Are those animal tests or animal and human tests that they're doing over there?

01:42:45 Speaker_01
Whatever defines safety. It depends on the chemical. It depends on what the product is. I can't answer that in general.

01:42:52 Speaker_00
So that might be a good avenue for changing legislature here, right? To install something similar to REACH.

01:42:59 Speaker_01
Absolutely, but it's not going to happen, I don't think.

01:43:02 Speaker_00
No?

01:43:03 Speaker_01
No, because there's too many forces against that. It's very, very hard for manufacturers to make changes. I'll give you one example. So you know that, you might not know, but should know that phthalates are very prevalent in the hospital setting.

01:43:20 Speaker_01
If you think of a tube, you know, to dialysis, to chemotherapy, to IV, that's all phthalates, right? And that's going into your body. And there was a recently, a bill passed in California that DEHP could not be in IV bags. It's fantastic, a success.

01:43:40 Speaker_00
in the actual bag. The bags could not contain these endocrine disruptors. Yes. DEHP specifically. DEHP.

01:43:47 Speaker_01
Diethylhexyl phthalate, the most antiandrogenic phthalate. So that was a great step forward, but that's like one chemical, right? in one product, and that was a battle. So you see how hard it is to do this. Extremely hard.

01:44:06 Speaker_01
There's a company, B. Braun, which makes hospital products, and they are very forward-thinking, and they set up a factory in Florida to make alternative IV bags out of another product, polyolefin.

01:44:24 Speaker_01
The problem is that we're not sure about the safety of polyolefin. So it gets really difficult. You can say remove DHP, but now we scientists have to say, what does it mean for a chemical to be safe? And we don't know that.

01:44:41 Speaker_01
I don't mean to disillusion you and your listeners, but that's a huge challenge that we're up against.

01:44:48 Speaker_01
We know it's safer, and we know what the bad actors are, and we know the things we don't want to be exposed to, but we have to be careful when we think about what do we want to put in instead.

01:45:01 Speaker_00
Yeah, I'm thinking about this. A former president of Stanford who also happened to be a family friend years ago, he's since passed. Don Kennedy, when he retired as President Stanford went in, my understanding is that he went and directed the FDA.

01:45:20 Speaker_00
And I was just thinking to myself, like, when did this happen? Because I know he was super into health. He was like an avid runner. He was very fit, well into his seventies. Yeah, hip replacement, kept running, or maybe it was knee replacement.

01:45:33 Speaker_00
I don't know. The guy was obsessed with health. And so I don't think that there's a lack of interest in health at the level of things like the FDA. And, but there's clearly a problem.

01:45:47 Speaker_00
And I'm just trying to think of solutions and it seems to all boil down to what we can take control of in our home. Like when we go to a restaurant, it's challenging to know like what they're doing in the kitchen.

01:46:00 Speaker_00
And at some point it becomes neurotic to... Although I know people that won't go to restaurants where they use seed oils. There's this whole new thing cropping up about avoiding seed oils, but maybe they're more significant issues. Who knows?

01:46:14 Speaker_00
The seed oil crowd is pretty intense. And I like olive oil anyway, so I err to that.

01:46:19 Speaker_00
But I think if people are interested in limiting their exposure to these endocrine disruptors, one of the key questions that's going to come up again and again, especially in light of PCOS and sperm counts is,

01:46:31 Speaker_00
we can't control what happened to us during pregnancy. But once we have some sense of agency over what we put into our body and how we put it into our body, do you think that there's a, that there's plasticity and resilience to this system?

01:46:49 Speaker_00
So, you know, God forbid, if somebody was exposed to a lot of these things early on, can they, you know, by making changes, can they rescue themselves to any degree? No. So it's really just dependent on what your parents did.

01:47:01 Speaker_01
Yes. That's not to say that your own exposure cannot change things further and make things worse. But here's a fact. If a male's mother smokes when he's in the womb, then he has a, this is a Danish study by the way, 50% reduction in sperm count.

01:47:22 Speaker_00
If his mother smoked while he was in the room, how much smoking are we talking?

01:47:25 Speaker_01
I don't know.

01:47:26 Speaker_00
I don't remember.

01:47:27 Speaker_01
But the reason I bring this up is because there's nothing he can do to change that. Okay? If he smokes as an adult, he has, I think, a similar reduction in his sperm count. He can stop and his sperm will be restored. He can get his sperm health back.

01:47:45 Speaker_01
But whatever happened in the womb stays in the womb, if you will. It's developmental. It's not going to, you know, it's going to be there for life. And that's true for the brain as well.

01:47:56 Speaker_01
So I think anybody who's thinking of conceiving a pregnancy or pregnant, has a responsibility to really learn how to reduce their exposure because these things are, by the way, passed on for several generations.

01:48:12 Speaker_01
It's your child and your child's child because the germ cells for your grandchild are going to be carried within your child.

01:48:22 Speaker_00
So germ cells are not germs as in infectious germs. It's the cells that will produce the egg and sperm that germinate. Hence the word germ.

01:48:32 Speaker_01
So it's a huge responsibility. And I think people should take it very seriously that they have, you know, they're going to be affecting the health of subsequent generations. Some labs say it's seven generations.

01:48:46 Speaker_01
I don't know if that's true, but certainly three generations are affected. And so I should mention my book, can I mention that?

01:48:54 Speaker_00
Yeah, please, I'll mention it. Yeah, I believe I mentioned it in my introduction.

01:48:57 Speaker_01
Yeah, so in Countdown, two words, by the way, because if you say Countdown one word, you won't find it. But Countdown, we have two chapters on things you can do, very practical things you can do.

01:49:11 Speaker_01
and also websites you can go to and links you can go to. Now this came out a while ago, so 21, so there are many more things now, but I think it's a good start.

01:49:23 Speaker_00
how lonely are you in this expedition of identifying endocrine disruptors in food, in pesticides, in the sorts of things you're talking about? Like, is there a whole field of this, of excellent people?

01:49:38 Speaker_00
Are you a small team of people that are against the grain? I mean, I confess I, I don't know many people doing the sorts of work that you're doing, but you're the most public facing and prominent.

01:49:51 Speaker_00
And I guess my question is like, is the NIH funding a lot of this sort of thing?

01:49:57 Speaker_01
Absolutely. We're an army and it's international. And there is now a global plastics treaty under negotiation by the way.

01:50:08 Speaker_00
Tell us about the plastics treaty.

01:50:10 Speaker_01
People are trying to, create, get passed by various countries, an international plastics treaty. I don't want to talk a lot about it. I'm not involved in that process. But in the process, you could see, if you looked into there,

01:50:30 Speaker_01
hundreds of scientists and concerned citizens and activists and people in legislation who are working specifically on the chemicals in plastic. Now, plastic is really a bad actor. But it is not the only bad actor.

01:50:48 Speaker_01
So I want to just mention that plastic is really important, but pesticides are not plastic, and so on. So there are many other classes that you have to worry about, but certainly controlling our exposure to plastic is huge.

01:51:05 Speaker_01
You asked about scientists in this area.

01:51:09 Speaker_01
huge amount of science going on for this in this there's and it's funded by NIH and it's funded by the EU and Primarily, I think those are the two two funders of Scandinavia has funding within you know in Scandinavian countries, so there's a lot of work and a lot of very good people working really hard But it's a huge problem and it's been here since

01:51:36 Speaker_01
Well, plastic started to rise in popularity in 1950. So we have like 75 years to battle against and it's not going down anytime soon.

01:51:47 Speaker_00
Lifespan is increasing pretty significantly, presumably in large part because of the reduction in smoking.

01:51:55 Speaker_01
And control of infectious disease.

01:51:56 Speaker_00
And control of infectious diseases. But lifespan is definitely increasing. Whereas the use of plastics has clearly increased. And so I guess one could argue that we're living longer, but we are less robust than we were, less reproductively competent.

01:52:18 Speaker_00
Is that?

01:52:19 Speaker_01
The people that are reflected in that long lifespan were not necessarily exposed early in life, which is when it's most critical. So, you know, I was born in 1936. There was no plastic then.

01:52:33 Speaker_01
There was no, you know, and there were other things, of course, but not as they are today.

01:52:39 Speaker_01
So I don't think that you can make the inference that because we're living longer, plastic growth, you know, the growth of the plastic industry is somehow driving that longevity. Absolutely not. Absolutely not.

01:52:53 Speaker_01
I think what it's driving is decrease in fertility. And what's happening is that the shift in populations is pretty dramatic. The pyramid used to be like this.

01:53:04 Speaker_01
I'm making a triangle with my arms showing very few people on top and a lot of people on the bottom. But what's happening is that that's getting inverted. So we're getting more and more people on top and fewer and fewer people on the bottom.

01:53:17 Speaker_00
Birth rates are way down.

01:53:19 Speaker_01
Birth rates are way down. enormous problem for societies because the people in that small support group at the bottom can't drive the society to support. the large growth on top. You see what I'm saying?

01:53:37 Speaker_00
Is this true in other countries as well?

01:53:38 Speaker_01
Yes, absolutely. Absolutely. It's all over the world. And the decline in fertility, in my mind, is probably, well, one of the biggest challenges we're facing now. Because it's everywhere, it's very acute, and there's only limited things we can do

01:54:01 Speaker_01
There's a wonderful website, it's by the World Bank, put out by the World Bank, it's called Fertility Data. If you go in there, you can see what is the fertility rate every year, but you can put

01:54:16 Speaker_01
you know, plug in a country or a year and see what the fertility rate in each country in the world each year, and you can see that. And what you see is that a decline, about the same rate as sperm decline, by the way, about 50% in 50 years.

01:54:35 Speaker_01
The critical point for fertility is two. So what's that mean? That's called replacement, and that's two people replace themselves with a total fertility rate of two. Actually, 2.1 because you have a little bit of loss.

01:54:49 Speaker_01
But 2.1, you're good to go, society. When you fall below that, you're shrinking. And there are many countries in the world that are below that, including the United States. And for example, the worst I've seen is actually South Korea, which is at 0.78.

01:55:07 Speaker_01
Wow. Japan is at 1. So large parts of the world are just not replacing themselves. And why that is, is maybe another discussion, or we can talk about it. I don't know if you want to go into that. But it's not just Burma, for sure.

01:55:26 Speaker_00
You know, along those lines, let's talk about egg count and quality. You mentioned the PCOS results earlier.

01:55:33 Speaker_00
Before we were on Mike, you mentioned an interesting study that you did about the use of electric blankets and assessing whether or not the use of electric blankets had impacted egg number or quality in women. And the answer was,

01:55:49 Speaker_01
Actually, what we looked at in women, I'm sorry to correct you, but it was the outcome of their pregnancy, their fertility, and if they got pregnant, how did that turn out? Excuse me.

01:55:59 Speaker_00
Thank you for that clarification.

01:56:01 Speaker_01
But I'm sure there'd be a lot of other studies that have looked at that. I just have been away from that field for a long time.

01:56:08 Speaker_01
So far, I don't see convincing evidence that the use of cell phones or other exposures to electromagnetic radiation are affecting our pregnancies and our fertility. That's not to say it's not happening, but I have not looked at it.

01:56:25 Speaker_01
And I don't like to make statements about things I haven't looked at.

01:56:29 Speaker_00
Yeah, my understanding of the cell phone data for sperm count and motility, aka quality,

01:56:38 Speaker_00
discussed a meta-analysis covering this on the podcast previously is that there are some heat effects of cell phone use and keeping the phone in the pocket that may, I want to be careful here, impact sperm count and motility.

01:56:53 Speaker_00
quality, but direct effects of EMFs on sperm, there's no evidence that it is disrupting sperm, at least to my knowledge.

01:57:03 Speaker_01
I honestly have to say, I'm just going to say I don't know, but I do know that heat is related. to fertility and sperm count. And you can look at the birth rates as a function of the month of conception.

01:57:19 Speaker_01
And you can see that, for example, in warm months, in warm climates, there's less. So heat does play a role. But how much that's tied to cell phone use, I think that's something that's now under investigation by a lot of groups.

01:57:34 Speaker_01
And we'll see what they find.

01:57:36 Speaker_00
Yeah, the data on sitting more than a few hours a day on having legs that are very large as a consequence of obesity, or even just legs that are large, heating the scrotum and those data are fairly

01:57:49 Speaker_00
I would say solid in terms of the relationship to reducing sperm count. Heat is not good for sperm, which is why the scrotum has the features that it does to move the testicles further or closer to the body.

01:58:04 Speaker_00
Getting back to egg count and quality, there's some evidence that girls are entering puberty earlier, but that, Women are also undergoing perimenopause menopause earlier. Do we know what that is the consequence of?

01:58:20 Speaker_01
There are several new papers actually on the menopausal age showing relation to a number of chemicals, but I can't quote them to you right now. I don't remember which class it was that they looked at, but I think that's right.

01:58:36 Speaker_01
I think there is growing evidence that earlier, you know, fewer, It's also called premature ovarian failure, so that women are just not producing the eggs as long as they used to. I just want to say something about the fertility.

01:58:57 Speaker_01
Can we go back to fertility? So when this comes up, and I'm sure you've seen the literature, there's a lot of literature on this, that say fertility is going down, fewer children are being born.

01:59:11 Speaker_01
A, people say, well, that's a good thing because it's less of a load on the planet, which is another discussion. And then they say, well, this is due to choice, that people are choosing to have fewer children.

01:59:24 Speaker_01
And they're choosing to delay childbearing until they're no longer as fertile. They're using more contraception. Women are more educated. They're entering the workforce. All of these social factors are given as the reason for decline in fertility.

01:59:43 Speaker_01
And I just need to point out whenever I hear this that it's not just human fertility that's declining. The number of species that are becoming extinct is increasing rapidly and there's there been for

02:00:04 Speaker_01
at least 40 years evidence that those pesticides that affect us are affecting animals as well. And so the decline in fertility in non-human species cannot be attributed to delayed childbearing or use of contraception. Or rent crisis, right?

02:00:23 Speaker_00
And it's interesting because we hear we usually hear first about species that are about to go extinct, that are badly endangered. I don't know what the proper language is, but it was about to go distinct.

02:00:36 Speaker_00
Like the Florida panther, or we hear that there are these species that there's a very small subset of them left. The black-footed ferrets in Montana, I think one ferret, his name is Scarface, sired something like 300 litters that then led to the

02:00:51 Speaker_00
Eventually they started out breeding, because if you do too much inbreeding, obviously it's not good. But then they were able to at least partially recover, maybe fully recover those populations.

02:01:01 Speaker_00
And people forget the domino effect of these ecosystems when one species is compromised. Like when the black-footed ferrets, I know it might sound kind of silly, were compromised in terms of their populations.

02:01:14 Speaker_00
The prairie dog population went up, the grasses were getting eaten far more.

02:01:18 Speaker_00
And then there's all these downstream consequences on bugs and I'm not an expert in this, but one doesn't have to be an expert to understand like you move one pin here and the whole web moves.

02:01:31 Speaker_00
And so, or you move one node and the whole web reconfigures. And that's what nature has been doing for, millions of years, right?

02:01:41 Speaker_00
But at some point it is conceivable, no pun intended, that we are going to be the species on the endangered species list, right? I mean, that's not like an outrageous sci-fi movie.

02:01:54 Speaker_00
Like at some point humans might be added to the endangered species list.

02:01:57 Speaker_01
With the exception that we have, we're very clever. And so we found a lot of ways to do medically assisted conception.

02:02:07 Speaker_00
Right, ICSI, the literally gentle grabbing of one sperm and forcing it to fertilize the egg is something we've covered on this podcast in our fertility episode with Natalie Crawford and a solo episode that I did.

02:02:24 Speaker_00
There are questions that people have, reasonable questions about whether or not the offspring of those types of scenarios are the same as the- Right.

02:02:33 Speaker_00
the genetic probability experiment, as you mentioned before, of having, you know, 200 million sperm and then letting nature select the one that is most robust in that environment.

02:02:45 Speaker_01
Yeah. And, you know, the number of technologies is increasing. We're a very clever species. And for example, I don't know if you've heard of gametogenesis. So it is now possible to create an embryo from a sperm cell, from a skin cell.

02:03:06 Speaker_01
Skin cell can produce a sperm cell and an egg cell.

02:03:11 Speaker_00
So you give it the right transcription factors and you can...

02:03:15 Speaker_01
So this is kind of interesting, exciting and scary.

02:03:18 Speaker_00
This is like the, what is it? I think the vultures, the females, there's some way in which two female vultures or maybe a single female vulture can create offspring in the absence of a male. There's also a three-party IVF.

02:03:34 Speaker_00
I don't know if you're aware of this, where this was developed where there's a mitochondrial disease. You can take the two eggs, one from the, intended mother, you take the nucleus.

02:03:45 Speaker_00
So you get the DNA, you put it into an egg of somebody that where the DNA has been removed, but where the spindles, which are rich with mitochondria are from a typically a much younger host. And then you use a sperm. So it's actually three parents.

02:04:00 Speaker_00
It's the spindle of one mom, the DNA of another mom and a sperm. They do this in the UK for mitochondrial disease. It's still illegal in the United States as far as I understand. And it's done in other countries. And in theory,

02:04:12 Speaker_01
legal issues must be.

02:04:14 Speaker_00
Yeah, but in theory, this would allow women of any age, provided they still have eggs, to have their DNA propagated forward because the DNA can be put into a younger egg that has the spindle quality that allows for the production of more cells.

02:04:35 Speaker_00
I mean, this can and has been done in humans.

02:04:38 Speaker_01
Yeah.

02:04:38 Speaker_00
Yeah.

02:04:39 Speaker_01
So we're, I mean, you and I won't think of all the things that will be developed in the next 10, 20 years to meet the challenge of declining fertility by ordinary conception. I mean, I think that's how we're going to solve this problem for us.

02:04:57 Speaker_01
We're going to just be smarter and smarter about how to do medically-assisted conception. And then the question is going to be, and it'll take time to know this, is whether there are adverse effects in the offspring.

02:05:19 Speaker_01
It's a little tricky because, for example, if you use the sperm of an infertile couple and you see, let's say the son is subfertile, that's born that way, but you do it, you know, in a test tube or whatever. And then you can say, well, maybe

02:05:35 Speaker_01
That's because the father was infertile and he's got inheritance from the father from that. You know what I'm saying?

02:05:41 Speaker_01
So you can't know whether the, if you see an adverse effect in an offspring, you have to be very careful that it's not something that they've gotten because of problems that led the couple to seek assisted reproduction. You follow me?

02:05:57 Speaker_00
Yeah. Yeah. Super challenging, fascinating problem. So in anticipation of this, sit down together. I put a question out on X, formerly known as Twitter.

02:06:12 Speaker_00
I let people know that I was hosting an expert in endocrine disruptors, in phthalates and pesticides, reproductive implications, et cetera. And I asked for questions and they

02:06:27 Speaker_00
came up with a huge number of excellent questions, many of which you've already answered. Things like, is tap water safe? What can we do to our tap water? You mentioned you distill water.

02:06:38 Speaker_00
My understanding is that reverse osmosis provided there's remineralization, excuse me, difficult word to say, can also be effective, et cetera. There were a lot of questions about cosmetics and laundry detergents.

02:06:53 Speaker_00
I don't know if we discussed laundry detergents. What do you use in terms of laundry detergent or that is presumably one can find- I don't even remember. Okay.

02:07:04 Speaker_01
Don't go by my products.

02:07:05 Speaker_00
Okay.

02:07:07 Speaker_01
For one thing, I'm not going to be pregnant anytime soon.

02:07:09 Speaker_00
No. I believe there are some solutions related to the, like, instead of bleach, people can use hydrogen peroxide.

02:07:21 Speaker_01
I can't speak about specific products, actually. Okay. You know, I can tell you who can, maybe you might like to talk to her.

02:07:27 Speaker_01
So you remember I mentioned Million Marker, the company that did the inventory, not the company, well, they are a company, but, so they, look at Million Marker, I think you'd be interested. OK.

02:07:39 Speaker_01
And the person who runs that, Jenna Wah, is a Chinese-American and a friend of mine. And we're going to be writing a grant together. And she participated in the film. So our participants sent their. So if you go to Million Marker,

02:07:57 Speaker_01
You log on, and if you agree to pay whatever it is, $199, I think, you send your urine in, they give you a kit, you send your urine in, and they test it for all these things in your urine. So you know what's in your body.

02:08:09 Speaker_01
You might want to think about it. It might be interesting. And then if you pay another $100, I think you get this counseling and so on, blah, blah. So you can see the different levels. But she knows all about products.

02:08:21 Speaker_01
I don't know about product because it's a moving target. I don't, and also I don't like to talk about product names because it sounds like I'm endorsing them.

02:08:29 Speaker_00
So- Yeah, right. And we won't expect you to give product names and I'll follow your recommendation that you just gave. Somebody asked about food dyes, just generally the dyes in foods. I saw an incredible study recently that Science Magazine covered.

02:08:44 Speaker_00
So Science Magazine, very reputable, of course. Yellow number five, I forget what the precise name is, but the thing that makes Cheetos really bright, they put it on the bellies of adult mice and it literally makes them translucent.

02:08:58 Speaker_02
You can see the organs.

02:09:01 Speaker_00
It's wild. It's so scary. I sent it to Rogan and he, I won't, he was like, whoa, his version of whoa. I was like, I also said, whoa.

02:09:11 Speaker_01
He probably said, holy shit, right? Or worse. No, no.

02:09:16 Speaker_00
I'm not going to say what it said, but he didn't curse. There were a number of questions about household items.

02:09:21 Speaker_00
Again, we're not looking for specific products, but for instance, soaps, body wash, cleaning sprays, floor cleaners, laundry related cleaners. Do any or all of these contain endocrine disruptors unless one is careful to find the ones that don't? Okay.

02:09:40 Speaker_00
Receipts, how serious is it? Should we be concerned about the BPAs and other endocrine disruptors on receipts?

02:09:47 Speaker_01
So- And my suggestion is just ask for an electronic receipt and then you don't have to deal with it. Yeah. But they're definitely absorbed into your body.

02:09:58 Speaker_00
any impact of endocrine disruptors of the sort we've talked about today on the thyroid system? Presumably in the bad direction.

02:10:08 Speaker_01
I mean, this is an interesting point. Let me just say another word about it. So there was an ongoing study in the Faroe Islands off of Denmark, and they studied PFAS chemicals.

02:10:24 Speaker_01
and showed that people who fished there, there were fisher people and they ate the fish and they were getting high levels of PFAS in their body and had, and this is published, effects on their immune response.

02:10:40 Speaker_01
So my concern, and I don't know if anyone's looked at this, is given everyone's vaccination, is our response to vaccination now altered by these chemicals? I don't know, but I think it's a really interesting question.

02:10:56 Speaker_01
But there is a whole field of the effect of these chemicals on the thyroid system. And there's a lot of evidence that it's adverse.

02:11:04 Speaker_00
Can these endocrine disruptors be detoxed from the body? Is there anything that we can do? What's the quickest ways? Things like sweating. Are there ways to improve liver clearance of these endocrine disruptors?

02:11:17 Speaker_01
The answer to that depends on the class of chemicals. So the chemicals that are water soluble, in particular the phthalates and the bisphenols, leave the body in a matter of hours. You don't have to do anything. You just have to stop taking them in.

02:11:34 Speaker_01
Right? The forever chemicals, the PFAS chemicals, pesticides, so it has to do with how they're handled by the body. If they're water soluble, you pee them out. If they're fat soluble, they're going to be around for a long time.

02:11:53 Speaker_01
So it just depends on the chemical structure of the compound.

02:11:59 Speaker_00
There was a question about nonstick pans. You covered that earlier. If someone had to pick between nonstick coated pans versus seasoned iron pans.

02:12:06 Speaker_01
No question, iron. There's no risk associated with seasoned iron pans.

02:12:12 Speaker_00
a number of other questions, such as why does Europe have such more stringent laws, et cetera. Lots of questions about atrazine, questions about ointments and fragrances you've covered.

02:12:24 Speaker_00
And I must say that as I scroll through these hundreds of questions, if not more, you've done an amazing job at clarifying for us

02:12:38 Speaker_00
what's known, what is not known, and essentially where it's a probably should avoid, definitely avoid, and look, we just don't know.

02:12:50 Speaker_01
And- Well, you know, I have to distinguish between we just don't know and I just don't know. It's not, I mean, there are many things that I don't know. It's a huge field. So, you know, maybe with some, you know, ask the question of chat GPT.

02:13:06 Speaker_00
Yeah, we'll be certain to ask chat GPT and we will be certain to ask other experts in these areas, but I just want to make very clear.

02:13:20 Speaker_00
I and everyone listening and watching truly appreciate the work that you've been doing in this area for a number of years.

02:13:26 Speaker_00
We're so grateful that you took that airline flight with this chemist that you mentioned, that you stored the urine of those pregnant women, that you analyzed it and that you've gone down this path of exploring things that are really disruptive to our health and potentially to the,

02:13:46 Speaker_00
existence of our species, as we talked about earlier, there is the possibility that we go extinct, not because of a meteor, but because we fail to replace ourselves and that we fail to replace ourselves because we destroy our biological ability to replace ourselves.

02:14:04 Speaker_00
I think it's hard for people to internalize that very real possibility because we feel ourselves sitting in traffic with thousands of other people and go, there's too many people, right? This kind of thing.

02:14:17 Speaker_00
I wanna thank you for the work that you've been doing and continue to do for your willingness to write books and to educate the public on podcasts like this and others, because these are topics that are pretty emotionally loaded for people.

02:14:31 Speaker_00
I don't think anything gets people quite as inflamed as the idea that what they've been ingesting and exposed to, especially in terms of consumables that they've spent their hard earned money on,

02:14:42 Speaker_00
have been harming them and their offspring and generations to follow, that there's something that really lands deep in that way. But you've also offered us a lot of possibility and a sense of agency over these things.

02:14:57 Speaker_00
And I love that you weave your math and statistics and probability theory background into all of this, because what comes through is intense curiosity, intense rigor, and a real desire to do good.

02:15:11 Speaker_00
So thank you so much for joining us and please come back again as you make more discoveries.

02:15:17 Speaker_01
Thank you.

02:15:18 Speaker_00
Thank you for joining me for today's discussion with Dr. Shauna Swan. To learn more about her work and to find a link to her excellent books on these topics, please see the links in the show note captions.

02:15:29 Speaker_00
Also, I should mention that if you're interested in learning more about microplastics and endocrine disruptors, I did a solo episode of the Huberman Lab podcast on that topic, and that is also linked in the show note captions.

02:15:40 Speaker_00
If you're learning from and or enjoying this podcast, please subscribe to our YouTube channel. That's a terrific zero cost way to support us. In addition, please follow the podcast on both Spotify and Apple by clicking follow on Spotify and Apple.

02:15:53 Speaker_00
And on both Spotify and Apple, you can leave us up to a five-star review. Please also check out the sponsors mentioned at the beginning and throughout today's episode. That's the best way to support this podcast.

02:16:03 Speaker_00
Also, if you have any questions for me or comments about the podcast or guests or topics that you'd like me to consider for the Huberman Lab podcast, please put those in the comment section on YouTube. I do read all the comments.

02:16:14 Speaker_00
For those of you that haven't heard, I have a new book coming out. It's my very first book. It's entitled Protocols, An Operating Manual for the Human Body.

02:16:21 Speaker_00
This is a book that I've been working on for more than five years, and that's based on more than 30 years of research and experience. And it covers protocols for everything from sleep

02:16:31 Speaker_00
to exercise, to stress control, protocols related to focus and motivation. And of course, I provide the scientific substantiation for the protocols that are included. The book is now available by presale at protocolsbook.com.

02:16:45 Speaker_00
There you can find links to various vendors. You can pick the one that you like best. Again, the book is called Protocols, an Operating Manual for the Human Body.

02:16:54 Speaker_00
If you're not already following me on social media, I am Huberman Lab on all social media platforms. So that's Instagram, X, formerly known as Twitter, Threads, Facebook, and LinkedIn.

02:17:03 Speaker_00
And on all those social media platforms, I discuss science and science-related tools, some of which overlap with the content of the Huberman Lab podcast, but much of which is distinct from the content covered on the Huberman Lab podcast.

02:17:14 Speaker_00
Again, that's Huberman Lab on all social media platforms.

02:17:17 Speaker_00
And if you haven't already subscribed to our Neural Network newsletter, our Neural Network newsletter is a zero cost monthly newsletter that includes podcast summaries, as well as protocols in the form of brief one to three page PDFs.

02:17:29 Speaker_00
These protocols cover things like deliberate cold exposure, deliberate heat exposure, how to optimize your dopamine, how to improve your sleep, all available at zero cost.

02:17:38 Speaker_00
To access these newsletters, simply go to hubermanlab.com, go to the top right corner menu, scroll down a newsletter and enter your email. And I should mention that we do not share your email with anybody.

02:17:49 Speaker_00
Thank you once again for joining me for today's discussion with Dr. Shauna Swan. And last, but certainly not least, thank you for your interest in science.